Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development

Li, Hai-chang; Guan, Yue; Zhou, Xin; Li, Zhong-Guang; Zhao, Serana Li; Chen, Peng; Tan, Tao; Zhu, Hua; Bergdall, Valerie; Xu, Xuehong; Ma, Jianjie; Guan, Jianjun

doi:10.1016/j.bioactmat.2022.03.017

Cited by 12 publications

(9 citation statements)

References 57 publications

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“…On day 14, the wounds dressed with PTβR2I/Gel exhibited the highest density of K14 + hair follicles, which is a hallmark of successful healing at the end stage (Fig. 3g, h ) 83 , similar to that in surgically unwounded db/db mice ( p > 0.05). These results demonstrate that wound dressings based on the PTβR2I and ROS scavenging hydrogel were able to effectively accelerate keratinocyte migration and hair follicle formation, leading to faster reepithelization in diabetic mice.…”

Section: Resultsmentioning

confidence: 55%

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Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing

Guan

Zhong

et al. 2023

npj Regen Med

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Various therapies have been utilized for treating diabetic wounds, yet current regiments do not simultaneously address the key intrinsic causes of slow wound healing, i.e., abnormal skin cell functions (particularly migration), delayed angiogenesis, and chronic inflammation. To address this clinical gap, we develop a wound dressing that contains a peptide-based TGFβ receptor II inhibitor (PTβR2I), and a thermosensitive and reactive oxygen species (ROS)-scavenging hydrogel. The wound dressing can quickly solidify on the diabetic wounds following administration. The released PTβR2I inhibits the TGFβ1/p38 pathway, leading to improved cell migration and angiogenesis, and decreased inflammation. Meanwhile, the PTβR2I does not interfere with the TGFβ1/Smad2/3 pathway that is required to regulate myofibroblasts, a critical cell type for wound healing. The hydrogel’s ability to scavenge ROS in diabetic wounds further decreases inflammation. Single-dose application of the wound dressing significantly accelerates wound healing with complete wound closure after 14 days. Overall, using wound dressings capable of adaptively modulating TGFβ pathways provides a new strategy for diabetic wound treatment.

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Section: Resultsmentioning

confidence: 55%

“…3d ). In addition, more K14 + keratinocytes in the basal layer underwent differentiation into K10 + keratinocytes in the suprabasal layers 83 , 107 .…”

Section: Discussionmentioning

confidence: 99%

Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing

Guan

Zhong

et al. 2023

npj Regen Med

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“…TRIM family members have been reported to sustain cellular homeostasis balance under oxidative stress. For example, recombinant human MG53, namely TRIM72, protected hair follicle stem cells from oxidative stress-induced apoptosis [ 107 ]. ROS can upregulate TRIM37 during HBV (Hepatitis B)-associated hepatic fibrosis which is a high risk factor for hepatocellular carcinoma [ 108 ].…”

Section: The Trim Family and Cancer Pathologymentioning

confidence: 99%

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

et al. 2022

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The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions and biological processes. TRIM family also contributes to cancer initiation, progress, and therapy resistance, exhibiting oncogenic and tumor-suppressive functions in different human cancer types. Moreover, TRIM family members have great potential to serve as biomarkers for cancer diagnosis and prognosis. In this review, we focus on the specific mechanisms of the participation of TRIM family members in tumorigenesis, and cancer development including interacting with dysregulated signaling pathways such as JAK/STAT, PI3K/AKT, TGF-β, NF-κB, Wnt/β-catenin, and p53 hub. In addition, many studies have demonstrated that the TRIM family are related to tumor resistance; modulate the epithelial–mesenchymal transition (EMT) process, and guarantee the acquisition of cancer stem cells (CSCs) phenotype. In the end, we havediscussed the potential of TRIM family members for cancer therapeutic targets.

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“…[ 3 ] Research has been devoted to the study of various functional wound dressings that protect wounds, prevent infection, accelerate cell proliferation, and improve tissue remodeling. [ 4–7 ] The most frequently used strategies include the slow release of growth factors, loaded antimicrobial particles, loaded cells, modulation of local inflammatory response, removal of oxygen free radicals, the provision of adequate oxygen supply to the wound, and other biochemical approaches. [ 8–13 ] These dressings, however, are usually expensive and complicated to fabricate.…”

Section: Introductionmentioning

confidence: 99%

Novel Temperature‐Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK‐Mediated Mechanosensitivity

Huang

Jiang

et al. 2022

Adv Healthcare Materials

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Wound healing is a significant problem in clinical management. Various functional dressings are studied to promote wound healing through biochemical factors. They are generally expensive, complex to fabricate, and may adversely affect the wound. Mechanical forces are the critical regulators of tissue repair. Although contraction is shown to promote wound healing, the underlying mechanisms are not fully understood. In this study, a novel adhesive temperature‐sensitive mechanically active hydrogel with a simple and inexpensive preparation process is developed. The dressing is able to adhere to the wound surface and actively contract the wound in response to body temperature. This mechanical contraction enhances the proliferative activity of basal cells, reduces the inflammatory response of the wound, and promotes wound healing. Furthermore, RNA‐seq clarifies how the gene regulatory network is regulated by contraction. Finally, using pharmacological inhibitors, YAP and MEK are identified as the key signaling molecules for contraction‐mediated tissue healing in vivo.

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Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development

Cited by 12 publications

References 57 publications

Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing

Thermosensitive and antioxidant wound dressings capable of adaptively regulating TGFβ pathways promote diabetic wound healing

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

Novel Temperature‐Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK‐Mediated Mechanosensitivity

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