Sustained delivery of gemcitabine via in situ injectable mussel-inspired hydrogels for the local therapy of pancreatic cancer

Abstract

The issue on pervasively enhanced drug resistance of pancreatic cancer is fundamental to better understanding of gemcitabine-based chemotherapy. Currently available treatment plans containing injectable therapeutics are mainly engineered to improve...

Recent advances in fabricating injectable hydrogels via tunable molecular interactions for bio-applications

“…[162][163][164] Inspired by this rapid Mfps solidification behavior, many mussel-inspired injectable hydrogels have been designed by using catechol-based polymers. For example, Xu et al prepared an injectable hydrogel as a potential drug delivery platform by using oxidized-carboxymethylcellulose and carboxymethylchitosan, 165 which showed good injectability attributed to the shear thinning property of the dynamic iminecross-linked hydrogel. The as-prepared hydrogel also exhibited good bio-compatibility and sustained drug-release properties for up to a week in both in vitro and in vivo tests.…”

Hydrogel-Based Therapeutics for Pancreatic Ductal Adenocarcinoma Treatment

“…In vivo experiments showed that this hydrogel was capable of retaining GEM for 7 days, facilitated by the interaction mediated by the catechol groups of dopamine. Additionally, the presence of GEM also increased the swelling ratio of the drug-loaded hydrogel, potentially due to its disruption to the hydrogen bonds between the polymers [125,143,144]. Sepehr, Talebian et al capitalized on the affinity between dopamine and drugs to develop an alginate hydrogel which effectively released chemotherapy drugs, GEM or doxorubicin (DOX), for PDAC treatment.…”