Sustained Clinical Remission and Rate of Relapse After Tocilizumab Withdrawal in Patients with Rheumatoid Arthritis

Abstract

Longterm clinical remission is possible in a number of patients with RA after suspension of TCZ. This effect has also been reported with other biologic agents. Additional data are required to support recommendations for discontinuing a biological agent after achieving remission.

Turkish Compliance and Adaptation of EULAR 2013 Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-Modifying Antirheumatic Drugs: Expert Opinion of TLAR

“…71 Long-term clinical remission has been shown to be possible in some patients with RA after cessation of TCZ. In a study by Luis AguilarLozano et al, 72 45 RA patients who were in remission after the last TCZ infusion were assessed. Then, patients were followed every eight weeks for 12 months or until relapse.…”

Strategy for Dose Reduction and Discontinuation of Biological Agents in Rheumatoid Arthritis Remission

“…Включено 45 пациентов с РА (длитель-ность заболевания в среднем 14 лет), у которых на фоне комбинированной терапии ТЦЗ и МТ была достигнута ре-миссия (DAS28 ≤2,6). В этой группе ТЦЗ был отменен, а лечение МТ продолжено [25]. Через 1 год после отмены ТЦЗ ремиссия сохранялась у 44% пациентов.…”

Project: Recommendations on Treatment of Rheumatoid Arthritis Developed by All-Russian Public Organization «association of Rheumatologists of Russia» – 2014 (Part 1)

“…У пациентов, достигших стойкой ре-миссии (не менее 6-12 мес) на фоне комбинированной те-рапии МТ и ГИБП, возможно снижение дозы или отмена ингибиторов ФНОα [251][252][253][254][255][256][257][258][259][260][261][262], ТЦЗ [263][264][265], АБЦ [266] и РТМ [267]; при обострении возобновление терапии ГИБП в большинстве случаев позволяет достигнуть ремис-сии без развития резистентности к лечению. Рекомендация 24.…”