Sustained attention in cranial dystonia patients treated with botulinum toxin

Allam, Nasser; Frank, Jean Edith; Pereira, Cristiane da Silva; Tomaz, Carlos

doi:10.1111/j.1600-0404.2007.00862.x

Cited by 44 publications

(49 citation statements)

References 24 publications

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“…Attention deficit was reported by recent studies of patients with different types of dystonia, including primary generalized dystonia and focal dystonia (Allam, Frank, Pereira, & Tomaz, 2007; Scott et al., 2003). Attention deficit may indicate the disruption of the dorsolateral‐prefrontal loop, which involves the striatum, thalamus and prefrontal cortex, regions showing altered functional activity and microstructural abnormalities in dystonia (Yang et al., 2013; Zoons, Booij, Nederveen, Dijk, & Tijssen, 2011).…”

Section: Discussionmentioning

confidence: 85%

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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BackgroundThe nature and frequency of nonmotor symptoms in primary adult‐onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown.MethodsHamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE‐R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult‐onset dystonia (60 with BSP and 60 with CD) and 60 age‐, sex‐, and education level‐ matched healthy controls (HCs). Motor symptoms of BSP and CD patients were evaluated by Jankovic rating scale and Toronto Western Spasmodic Torticollis Rating Scale‐severity scale separately.ResultsTwenty patients had depression, and 29 patients had anxiety. The mean HAMD and HAMA scores were significantly higher in patient groups. Thirty‐six patients had cognitive decline based on the cut‐off score of 75. The total score and scores of each domain of ACE‐R were significantly lower in patient groups than that in HCs. Quality of sleep was impaired in patient groups, and patients with CD had worse quality of sleep than patients with BSP. Thirty‐three BSP patients and 43 CD patients suffered from sleep disorder separately. The frequency of excessive daytime sleepiness did not differ between patients and HCs. No significant correlation was found between NMS and motor severity in the two forms of dystonia.ConclusionsCurrent study suggests that NMS are prevalent in Chinese CD and BSP patients, and the motor severity of dystonia did not contribute to the severity of nonmotor symptoms. Assessment of nonmotor symptoms should be considered in clinical management of focal dystonia

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Section: Discussionmentioning

confidence: 85%

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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“…As previously suggested [2], some of these deficits may be related to the patients’ attempts to control their dystonia during cognitive testing. Supporting this, Allam et al [5] showed that improvement of blepharospasm following botulinum toxin was associated with significant improvement on a test of sustained attention.…”

Section: Introductionmentioning

confidence: 89%

“…Supporting this, Allam et al [5] showed that improvement of blepharospasm following botulinum toxin was associated with significant improvement on a test of sustained attention.…”

Section: Introductionmentioning

confidence: 89%

Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life

et al. 2013

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We investigated the effect of pallidal deep brain stimulation (GPi-DBS) in dystonia on cognition, mood, and quality of life and also assessed if DYT1 gene status influenced cognitive outcome following GPi-DBS. Fourteen patients with primary generalized dystonia (PGD) were assessed, measuring their estimated premorbid and current IQ, memory for words and faces, and working memory, language, executive function, and sustained attention, one month before and one year or more after surgery. Changes in mood and behaviour and quality of life were also assessed. There was a significant improvement of dystonia with GPi-DBS (69 % improvement in Burke-Fahn-Marsden score, p < 0.0001). Performance on five cognitive tests either improved or declined at post-surgical follow-up. Calculation of a reliable change index suggested that deterioration in sustained attention on the PASAT was the only reliable change (worse after surgery) in cognition with GPi-DBS. DYT1 gene status did not influence cognitive outcome following GPi-DBS. Depression, anxiety and apathy were not significantly altered, and ratings of health status on the EQ5D remained unchanged. In our sample, GPi-DBS was only associated with an isolated deficit on a test of sustained attention, confirming that GPi-DBS in PGD is clinically effective and safe, without adverse effects on the main domains of cognitive function. The dissociation between GPi-DBS improving dystonia, but not having a significant positive impact on the patients’ QoL, warrants further investigation.

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“…В отдельных исследованиях обнару-живается дефицит внимания у пациентов с цервикальной дистонией в сравнении со здоровыми пациентами [19]. После лечения ботулиническим токсином показатели внимания улучшались, что может свидетельствовать о вторичном характере этих расстройств, обусловленных дистоническим спазмом мышц [19]. Не исключено, что такие немоторные проявления дистонии, как боль и депрессия, также способствуют формированию дефицита внимания.…”

Section: когнитивные нарушенияunclassified

Focal Dystonias: Non-Motor Symptoms and Comorbidities

Толмачёва¹

2017

Med. sov.

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Дистония является распространенным экстрапирамидным заболеванием. Для нее характерны как моторные, так и немоторные проявления, к которым относятся боль, сенсорные нарушения, избыточная двигательная активность. Обсуждается вклад тревож-ных и депрессивных расстройств, нарушений сна в течение фокальной дистонии. Нередко именно немоторные проявления являются начальными симптомами дистонии. В ряде случаев немоторные проявления можно выделить в самостоятельные заболевания, которые сопутствуют дистоническому гиперкинезу и способствуют ухудшению качества жизни таких больных. Лечение немоторных симптомов позволит повысить эффективность терапии дистонии, а также повлиять на течение заболевания.Ключевые слова: дистония, немоторные симптомы, коморбидность, лечение. V.A. TOLMACHYOVA, PhD in medicine, Sechenov First Moscow State Medical University FOCAL DYSTONIAS: NON-MOTOR SYMPTOMS AND COMORBIDITIESDystonia is a common extrapyramidal disease. It is characterized by both motor and non-motor manifestations, which include pain, sensory disorders and excessive physical activity. The contribution of disturbing and depressed disorders, sleep disorders during the focal dystonia has been discussed. It is often the non-motor manifestations that are the initial symptoms of dystonia. In some cases, unmotorized manifestations can be isolated diseases that accompany dystonic hyperkinesis and contribute to the deterioration of the quality of life of such patients. Treatment of nonmotor symptoms will improve the effectiveness of dystonia therapy as well as affect the course of the disease.

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Sustained attention in cranial dystonia patients treated with botulinum toxin

Abstract: The results support the view that executive dysfunction in PCD is secondary to the disrupting effects of the symptoms. Treatment with BTX alleviates the symptoms and, consequently, improves sustained attention.

Cited by 44 publications

References 24 publications

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Pallidal stimulation for primary generalised dystonia: effect on cognition, mood and quality of life

Focal Dystonias: Non-Motor Symptoms and Comorbidities

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