Sustained Arc expression in adult-generated granule cells

Meconi, Alicia; Lui, Erika; Marrone, Diano F.

doi:10.1016/j.neulet.2015.07.029

Cited by 9 publications

(10 citation statements)

References 21 publications

(28 reference statements)

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“…These effects indicate that the blades of the DG show unique responses to brief spatial experience, consistent with previous literature [6, 7, 9, 19]. Although no main effect of genotype was observed ( F 1,138 = 0.13; p = 0.72), a significant genotype by behavioral group interaction ( F 4,138 = 6.29; p < 0.0001) was observed.…”

Section: Resultssupporting

confidence: 91%

“…As previously reported [6, 7, 9, 19], this brief exposure results in an increase in the number of granule cells expressing Arc in WT mice that perdures for at least 8 hours. However, by 240 min after exposure, the levels of Arc are reduced significantly more in the Egr3 −/− mice than their WT littermates, and this effect persists at 480 min.…”

Section: Resultssupporting

confidence: 73%

“…Both experimental evidence [20] and computational models [21] suggest that DG granule cells play a role in “tagging” the relative timing of events. It has been proposed that sustained Arc expression may provide a molecular mechanism to keep representations labile within the DG to sculpt and ultimately disambiguate representations for events that happen on the scale of hours [19]. Testing these ideas will be greatly facilitated by the identification of mechanisms that uniquely drive late-phase Arc transcription so that it may be selectively manipulated.…”

Section: Discussionmentioning

confidence: 99%

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Attenuated Late-PhaseArcTranscription in the Dentate Gyrus of Mice LackingEgr3

et al. 2017

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The dentate gyrus (DG) engages in sustained Arc transcription for at least 8 hours following behavioral induction, and this time course may be functionally coupled to the unique role of the DG in hippocampus-dependent learning and memory. The factors that regulate long-term DG Arc expression, however, remain poorly understood. Animals lacking Egr3 show less Arc expression following convulsive stimulation, but the effect of Egr3 ablation on behaviorally induced Arc remains unknown. To address this, Egr3−/− and wild-type (WT) mice explored novel spatial environments and were sacrificed either immediately or after 5, 60, 240, or 480 minutes, and Arc expression was quantified by fluorescence in situ hybridization. Although short-term (i.e., within 60 min) Arc expression was equivalent across genotypes, DG Arc expression was selectively reduced at 240 and 480 minutes in mice lacking Egr3. These data demonstrate the involvement of Egr3 in regulating the late protein-dependent phase of Arc expression in the DG.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Attenuated Late-PhaseArcTranscription in the Dentate Gyrus of Mice LackingEgr3

et al. 2017

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“…On the other hand, the results indicated that DG is more sensitive to BPA. The possible explanation of the DG sensitivity is that BPA may negatively affect neurogenesis in DG3441 and Arc has been reported to be continually expressed in new-born granule cells42. To our knowledge, this is the first report showing that Arc was implicated in BPA induced impaired dendrite and spine formation and spatial memory deficits.…”

Section: Discussionmentioning

confidence: 81%

Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats

Liu

Ding

Yang

et al. 2016

Sci Rep

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Bisphenol-A (BPA, 4, 4′-isopropylidene-2-diphenol), a synthetic xenoestrogen that widely used in the production of polycarbonate plastics, has been reported to impair hippocampal development and function. Our previous study has shown that BPA exposure impairs Sprague-Dawley (SD) male hippocampal dendritic spine outgrowth. In this study, the sex-effect of chronic BPA exposure on spatial memory in SD male and female rats and the related synaptic mechanism were further investigated. We found that chronic BPA exposure impaired spatial memory in both SD male and female rats, suggesting a dysfunction of hippocampus without gender-specific effect. Further investigation indicated that BPA exposure causes significant impairment of dendrite and spine structure, manifested as decreased dendritic complexity, dendritic spine density and percentage of mushroom shaped spines in hippocampal CA1 and dentate gyrus (DG) neurons. Furthermore, a significant reduction in Arc expression was detected upon BPA exposure. Strikingly, BPA exposure significantly increased the mIPSC amplitude without altering the mEPSC amplitude or frequency, accompanied by increased GABAARβ2/3 on postsynaptic membrane in cultured CA1 neurons. In summary, our study indicated that Arc, together with the increased surface GABAARβ2/3, contributed to BPA induced spatial memory deficits, providing a novel molecular basis for BPA achieved brain impairment.

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“…Activity‐regulated cytoskeleton‐associated protein (Arc) is an immediate early gene induced by a variety of conditions including seizures, exploration of novel environments, and spatial learning (Lyford, et al, ; Ramírez‐Amaya et al, ; Messaoudi et al, ; Farris et al, ) all of which activate hippocampal neurons. Basal Arc contents are very low, thus its presence has been widely used as a neuronal activity marker for in vivo analysis of robust neuronal activation (Toyoda et al, ) and for neural activity associated to several types of behavioral experiences (Vazdarjanova et al, , Ramirez‐Amaya et al, ; Carasatorre et al, ; Meconi et al, ).…”

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confidence: 99%

Behavior‐associated Neuronal Activation After Kainic Acid‐induced Hippocampal Neurotoxicity is Modulated in Time

Aguilar-Arredondo

López-Hernández

García‐Velázquez

et al. 2016

The Anatomical Record

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Kainic acid-induced (KA) hippocampal damage leads to neuronal death and further synaptic plasticity. Formation of aberrant as well as of functional connections after such procedure has been documented. However, the impact of such structural plasticity on cell activation along time after damage and in face of a behavioral demand has not been explored. We evaluated if the mRNA and protein levels of plasticity-related protein synaptophysin (Syp and SYP, respectively) and activity-regulated cytoskeleton-associated protein mRNA and protein levels (Arc and Arc, respectively) in the dentate gyrus were differentially modulated in time in response to a spatial-exploratory task after KA-induced hippocampal damage. In addition, we analyzed Arc+/NeuN+ immunopositive cells in the different experimental conditions. We infused KA intrahippocampally to young-adult rats and 10 or 30 days post-lesion (dpl) animals performed a hippocampus-activating spatial-exploratory task. Our results show that Syp mRNA levels significantly increase at 10dpl and return to control levels after 30dpl, whereas SYP protein levels are diminished at 10dpl, but significantly increase at 30dpl, as compared to 10dpl. Arc mRNA and protein levels are both increased at 30dpl as compared to sham. Also the number of NeuN+/Arc+ cells significantly increases at 30dpl in the group with a spatial-exploratory demand. These results provide information on the long-term modifications associated to structural plasticity and neuronal activation in the dentate gyrus after excitotoxic damage and in face of a spatial-exploratory behavior. Anat Rec, 300:425-432, 2017. © 2016 Wiley Periodicals, Inc.

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Sustained Arc expression in adult-generated granule cells

Cited by 9 publications

References 21 publications

Attenuated Late-PhaseArcTranscription in the Dentate Gyrus of Mice LackingEgr3

Attenuated Late-PhaseArcTranscription in the Dentate Gyrus of Mice LackingEgr3

Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats

Behavior‐associated Neuronal Activation After Kainic Acid‐induced Hippocampal Neurotoxicity is Modulated in Time

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