The article discusses the Sustainable Development Goals pursuant to the Resolution 70/1 of the UN General Assembly “Transforming our world: the 2030 Agenda for Sustainable Development” and the Roadmap for the UN Decade of Ocean Science for Sustainable Development. Recommendations are given on the creation of specific marine clusters as a tool for achieving the targets of SDG14 on the Caspian Sea, as well as their brief description. It is proposed to form five clusters: Astrakhan Cluster, Baku Cluster, Amirabad Cluster, Turkmenbashi Cluster, Aktau Cluster. The authors believe that the projects, initiatives and recommendations discussed in this article will effectively help achieve the targets of sustainable development in the Caspian Sea region by improving coordination of research programs, observation systems, enhancing the potential of young scientists, developing mechanisms for planning of marine space and significantly reducing the risks of marine activities in order to optimize management of marine resources, conserve biodiversity and ensure environmental protection of the Caspian Sea and its coastal zones.