Sustainable triazine-derived quaternary ammonium salts as antimicrobial agents

Abstract

The first examples of highly efficient antimicrobial triazine-derived bis imidazolium quaternary ammonium salts (TQAS) are reported.

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

“…They found that the side chain length of 14 had the best antibacterial effect. 67 Relevant reports pointed out that imidazole derivatives are expected to be promising antibacterial materials with high activity against multidrug-resistant bacteria. 68 Other heterocyclic QASs, such as derivatives of piperidine and pyridine, also exhibit highly effective antibacterial and antimicrobial activities.…”

“…Morandini et al synthesized a triazine compound with a long alkyl group and then reacted it with methylimidazole to prepare triazine-derived quaternary ammonium salts (TQASs) with two units of positive charge. They found that the side chain length of 14 had the best antibacterial effect . Relevant reports pointed out that imidazole derivatives are expected to be promising antibacterial materials with high activity against multidrug-resistant bacteria .…”

Recent biological applications of heterocyclic hybrids containing s-triazine scaffold

“…Likewise, molecular hybrids of s -triazine and imidazole (62) are also reported as quaternary ammonium salts as potent antibacterial agents. 71 Using the sustainable methodology, 2,4-dichloro-6-alkylamine- s -triazine was reacted with methyl imidazole to synthesize the targeted products in a very good yield of ∼90% in lesser time of 1.5 hours involving haloalkanes as the reactant. The chain length of the alkyl group ranged from C10–C18.…”

One-step antibacterial modification of polypropylene non-woven fabricsviaoxidation using photo-activated chlorine dioxide radicals

“…Recently, antimicrobial peptides, 13,14 cationic compounds, 15-17 metal nanoparticles, 18,19 and polymer nanoparticles [20][21][22] have received considerable attention because of their broad-spectrum activities. They absorb on the membranes of bacterial cell and induce leakage of the cell contents.…”