Sustainable release of nerve growth factor for peripheral nerve regeneration using nerve conduits laden with Bioconjugated hyaluronic acid-chitosan hydrogel

Xu, Haixing; Yu, Yi; Zhang, Lingxi; Zheng, Furong; Yin, Yi; Gao, Yuxiang; Li, Kebi; Xu, Jie; Wen, Jing; Chen, Hui; Lei, Zhixin; Huang, Zhijun; Yu, Dan; Jiang, Nan; Xu, Ping

doi:10.1016/j.compositesb.2021.109509

Cited by 38 publications

(23 citation statements)

References 57 publications

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“…For small-gap peripheral injuries, however, hollow tube conduits do seem to be effective. Furthermore, hollow tubes can be pre-loaded with hydrogels to improve their biological function [73].…”

Section: Axonal Interaction With Biomaterialsmentioning

confidence: 99%

The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review

Kaplan

Levenberg

2022

IJMS

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Peripheral nerve and spinal cord injuries are potentially devastating traumatic conditions with major consequences for patients’ lives. Severe cases of these conditions are currently incurable. In both the peripheral nerves and the spinal cord, disruption and degeneration of axons is the main cause of neurological deficits. Biomaterials offer experimental solutions to improve these conditions. They can be engineered as scaffolds that mimic the nerve tissue extracellular matrix and, upon implantation, encourage axonal regeneration. Furthermore, biomaterial scaffolds can be designed to deliver therapeutic agents to the lesion site. This article presents the principles and recent advances in the use of biomaterials for axonal regeneration and nervous system repair.

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Section: Axonal Interaction With Biomaterialsmentioning

confidence: 99%

The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review

Kaplan

Levenberg

2022

IJMS

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“…Since they exhibit shear-thinning properties in rheological studies as well as when being injected, some hydrogels have been applied as fillers in nerve guide channels (NGCs) in order to induce the regeneration of peripheral nerve tissue [ 48 , 141 , 150 , 151 ]…”

Section: Ha-based Specific Device For Various Applicationsmentioning

confidence: 99%

“…HA has been very successful in neural tissue engineering and supports the growth, differentiation and proliferation of neurites on a variety of substrates [ 151 , 185 ] ( Figure 4 ). HA hydrogel amends the viability and proliferation of neural progenitor cells [ 151 ]. This indicates the potential therapeutic approaches for peripheral nerve regeneration and CNS therapies.…”

Section: Ha-based Specific Device For Various Applicationsmentioning

confidence: 99%

“…Some hydrogels have shown good results in terms of their biocompatibility, architectural properties, mechanical features and their bioperformance in vitro and in vivo. The sustained release of NGF from these chitosan and HA-based hydrogels was well-controlled [ 141 , 151 , 189 ]. The porosity and viscoelastic properties of their systems are interesting for cell attachment.…”

Section: Ha-based Specific Device For Various Applicationsmentioning

confidence: 99%

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Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Djoudi

Molina-Peña²,

Ferreira³

et al. 2022

IJMS

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Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric property, polyelectrolyte feature and viscous nature. HA is a ubiquitous compound found in almost all biological tissues and fluids. So far, HA grades are produced by biotechnology processes, while in the human organism it is a major component of the extracellular matrix (ECM) in brain tissue, synovial fluid, vitreous humor, cartilage and skin. Indeed, HA is capable of forming hydrogels, polymer crosslinked networks that are very hygroscopic. Based on these considerations, we propose an overview of HA-based scaffolds developed for brain cancer treatment, central and peripheral nervous systems, discuss their relevance and identify the most successful developed systems.

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“…Biological and biochemical components such as cells and trophic factors that are added to a graft should also continue to function throughout this long duration of recovery [56][57][58][59]. Microspheres containing growth factors are one option for long-term release of growth factors [59][60][61].…”

Section: Prospects For Improving Neuron Cell Regrowthmentioning

confidence: 99%

Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization

Perrelle

Boreland

Gamboa

et al. 2022

Biomedical Materials & Devices

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Injuries to the nervous system present formidable challenges to scientists, clinicians, and patients. While regeneration within the central nervous system is minimal, peripheral nerves can regenerate, albeit with limitations. The regenerative mechanisms of the peripheral nervous system thus provide fertile ground for clinical and scientific advancement, and opportunities to learn fundamental lessons regarding nerve behavior in the context of regeneration, particularly the relationship of axons to their support cells and the extracellular matrix environment. However, few current interventions adequately address peripheral nerve injuries. This article aims to elucidate areas in which progress might be made toward developing better interventions, particularly using synthetic nerve grafts. The article first provides a thorough review of peripheral nerve anatomy, physiology, and the regenerative mechanisms that occur in response to injury. This is followed by a discussion of currently available interventions for peripheral nerve injuries. Promising biomaterial fabrication techniques which aim to recapitulate nerve architecture, along with approaches to enhancing these biomaterial scaffolds with growth factors and cellular components, are then described. The final section elucidates specific considerations when developing nerve grafts, including utilizing induced pluripotent stem cells, Schwann cells, nerve growth factors, and multilayered structures that mimic the architectures of the natural nerve.

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Sustainable release of nerve growth factor for peripheral nerve regeneration using nerve conduits laden with Bioconjugated hyaluronic acid-chitosan hydrogel

Cited by 38 publications

References 57 publications

The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review

The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization

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