“…[5][6][7][8] In order to solve the problem, some scientists have suggested that it is of great value to replace the widely used toxic organic solvents by safely, biodegradable, and environmentally friendly neoteric solvents for the development of sustainable pharmaceutical processes. 3,4,9,10 Ionic liquids (ILs) as neoteric solvents, with the advanced characteristics of non-volatility, non-flammability, and high recyclability, have been proposed as green solvents for the extraction, separation, crystallization, and purification of drugs. [11][12][13][14][15][16][17][18] Particularly, existing experimental data showed that most of imidazolium-based ILs were considered to be a biodegradable IL and to exhibit quite a low toxicity on human body, which made them even as the component of the active pharmaceutical ingredients (APIs).…”