Sustainable nano-pesticide platform based on Pyrethrins II for prevention and control Monochamus alternatus

Abstract

Background Pine wilt disease as a devastating forest disaster result from Bursaphelenchus xylophilus that spread by stem-borers Monochamus alternatus feeding on pine leaves, which has brought inestimable economic losses to the world's forestry due to lack of effective prevention and control measures. In this paper, we put forward a proposal for utilizing nanoHKUST-1 to encapusulate the Pyrethrins II that a nerve agent extracted from plant to control M. alternatus, including toxicity mechanism research, traceable biopesticide monitoring, and environment assessment for the first time. The highly biocompatible nanoHKUST-1 can solve the problems of poor water solubility, easy degradation and low control efficiency of Pyrethrins II. Results The results illustrated the biopesticide loading efficiency of PthII@HKUST-1 reached 85% and the cumulative release of pH-dependent PthII@HKUST-1 was up to 15 days (90%), and also effectively avoid photodegradation (pH 7.0, retention 60.9%). 50 nm PthII@HKUST-1 made it easily penetrate the body wall of MA larvae and transmit to tissue cells through contact and diffusion. Moreover, PthII@HKUST-1 can effectively enhance the cytotoxicity and utilization of Pyrethrins II, which will provide valuable research value for the application of typical plant-derived nerve agents in the prevention and control of forestry pests. PthII@HKUST-1 as an environmentally friendly nano-pesticide can efficiently deliver Pyrethrins II to the larval intestines and absorbed by the larvae. PthII@HKUST-1 could also be transmitted to the epidemic wood and dead wood at a low concentration (10 mg/L). Conclusion Here we speculate that nanoHKUST-1 will bring new opportunity to research biopesticide inhibition mechanism of different agricultural and forestry pests, which will break through the existing research limitations on development, utilization and traceable monitoring of biopesticide, especially for the study of targeting specific proteins. Graphical Abstract

Synthesis and characterization of a novel stimuli-responsive zein nano delivery system for the controlled release of emamectin benzoate

“…This can reduce the environmental pollution caused by one-time release and achieve the long-term effective control of the target pest. 32…”

Tannic Acid-Modified MXene as a Nanocarrier for the Delivery of β-Cyfluthrin as a Sustained Release Insecticide

“…Recently, nanomaterial-based pesticide delivery systems (PDSs) have drawn increasing interest for their controllable preparation route, improved water dispersion stability, high pesticide loading rate, sustained release, and enhanced insecticidal activity. − Materials including carbon nanomaterials, polymers, metal–organic frameworks, mesoporous materials, etc., are developed as nanocarriers for pesticide delivery in the past decade. , Especially, the stimuli-responsive controlled release of PDSs has attracted extensive interest because the pesticide release behavior can be accurately controlled according to exogenous stimuli, which will greatly improve the utilization and activity of pesticides. − For example, Kaziem et al developed a carboxymethyl starch-modified hollow mesoporous silica-based PDS for abamectin delivery and found that the release of abamectin can be controlled by pH and enzyme dual stimuli . Song and colleagues reported a carboxymethyl chitosan surface-decorated carbon nanoparticle for emamectin benzoate (EB) delivery and found that it exhibited pH-responsive release performance .…”

“…7−10 Materials including carbon nanomaterials, polymers, metal−organic frameworks, mesoporous materials, etc., are developed as nanocarriers for pesticide delivery in the past decade. 11,12 Especially, the stimuliresponsive controlled release of PDSs has attracted extensive interest because the pesticide release behavior can be accurately controlled according to exogenous stimuli, which will greatly improve the utilization and activity of pesti-cides. 13−17 For example, Kaziem et al developed a carboxymethyl starch-modified hollow mesoporous silicabased PDS for abamectin delivery and found that the release of abamectin can be controlled by pH and enzyme dual stimuli.…”

Chromosome‐level genome assembly of Dastarcus helophoroides provides insights into CYP450 genes expression upon insecticide exposure

“…Pine wilt disease can infect more than 50 kinds of pine trees, which has brought direct economic losses and ecological service value losses of more than 10 billion CNY per year in China 1 . Effective prevention and control of Monochamus alternatus Hope has become a key factor to cut off the transmission of this pine cancer 2 .…”

“…Pine wilt disease can infect more than 50 kinds of pine trees, which has brought direct economic losses and ecological service value losses of more than 10 billion CNY per year in China. 1 Effective prevention and control of Monochamus alternatus Hope has become a key factor to cut off the transmission of this pine cancer. 2 The chemical control method of spraying pesticides and the biological control technique of releasing natural enemy are widely used to kill larval and adult cerambycids in May to August.…”