Sustainable inhibition efficacy of liposome-encapsulated nisin on insoluble glucan-biofilm synthesis by<i>Streptococcus mutans</i>

Yamakami, Kazuo; Tsumori, Hideaki; Sakurai, Yoshinori; Shimizu, Yoshitaka; Nagatoshi, Kohei; Sonomoto, Kenji

doi:10.3109/13880209.2012.717227

Cited by 48 publications

(39 citation statements)

References 12 publications

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“…The encapsulation of nisin, which is able to inhibit the glucan synthesis by S. mutans, into liposomes composed of PC:PS prolonged the period over which the glucan synthesis was inhibited due to controlled release from the liposomes. [57] It should be mentioned that micelles, which in contrast to liposomes consist only of a single layer of amphiphilic molecules, were proposed for the prevention of dental caries for the same reasons as liposomes. Micelles of Pluronic 123-alendronate and Pluronic P85 containing the hydrophobic antibacterial agent farnesol were formed.…”

Section: Prolonged Contact Time: Treatment and Prevention Of Biofilm mentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

345

307

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Biofilms are matrix-enclosed communities of bacteria that show increased antibiotic resistance and the capability to evade the immune system. They can cause recalcitrant infections which cannot be cured with classical antibiotic therapy. Drug delivery by lipid or polymer nanoparticles is considered a promising strategy for overcoming biofilm resistance. These particles are able to improve the delivery of antibiotics to the bacterial cells, thereby increasing the efficacy of the treatment. In this review we give an overview of the types of polymer and lipid nanoparticles that have been developed for this purpose. The antimicrobial activity of nanoparticle encapsulated antibiotics compared to the activity of the free antibiotic is discussed in detail. In addition, targeting and triggered drug release strategies to further improve the antimicrobial activity are reviewed. Finally, ample attention is given to advanced microscopy methods that shed light on the behavior of nanoparticles inside biofilms, allowing further optimization of the nanoformulations. Lipid and polymer nanoparticles were found to increase the antimicrobial efficacy in many cases. Strategies such as the use of fusogenic liposomes, targeting of the nanoparticles and triggered release of the antimicrobial agent ensured the delivery of the antimicrobial agent in close proximity of the bacterial cells, maximizing the exposure of the biofilm to the antimicrobial agent. The majority of the discussed papers still present data on the in vitro anti-biofilm activity of nanoformulations, indicating that there is an urgent need for more in vivo studies in this field.

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Section: Prolonged Contact Time: Treatment and Prevention Of Biofilm mentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

345

307

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“…While unencapsulated nisin lost its potency within 6 h, only 76% of the nisin within nisinliposomes was released within this time, thus prolonging the inhibitory effects (173). Nisin has also been combined with sodium fluoride to provide a stronger bactericidal effect on S. mutans.…”

Section: Other Resistance Elements Biofilmsmentioning

confidence: 99%

Lantibiotic Resistance

Draper

Cotter

Hill

et al. 2015

Microbiol Mol Biol Rev

126

128

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SUMMARY The dramatic rise in the incidence of antibiotic resistance demands that new therapeutic options will have to be developed. One potentially interesting class of antimicrobials are the modified bacteriocins termed lantibiotics, which are bacterially produced, posttranslationally modified, lanthionine/methyllanthionine-containing peptides. It is interesting that low levels of resistance have been reported for lantibiotics compared with commercial antibiotics. Given that there are very few examples of naturally occurring lantibiotic resistance, attempts have been made to deliberately induce resistance phenotypes in order to investigate this phenomenon. Mechanisms that hinder the action of lantibiotics are often innate systems that react to the presence of any cationic peptides/proteins or ones which result from cell well damage, rather than being lantibiotic specific. Such resistance mechanisms often arise due to altered gene regulation following detection of antimicrobials/cell wall damage by sensory proteins at the membrane. This facilitates alterations to the cell wall or changes in the composition of the membrane. Other general forms of resistance include the formation of spores or biofilms, which are a common mechanistic response to many classes of antimicrobials. In rare cases, bacteria have been shown to possess specific antilantibiotic mechanisms. These are often species specific and include the nisin lytic protein nisinase and the phenomenon of immune mimicry.

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“…Findings suggest that nisin has a potential to be used as a bactericidal agent to prevent dental caries. Liposomal nisin was shown to inhibit S. mutans [5]. In addition, nisin did not appear to be toxic to normal human gingival fibroblast and epithelial cells [32].…”

Section: Nisin Against Cariogenic Streptococcimentioning

confidence: 91%

“…lactis [3]. The bactericidal activity of nisin against cariogenic streptococci was investigated in vitro and the findings indicated that nisin acts as an inhibitor of typical cariogenic streptococci [4,5]. It may be possible to use liposomes as a carrier for the effective administration of nisin.…”

Section: Introductionmentioning

confidence: 99%

“…With regard to liposome formulations, a variety of factors, such as lipid composition, cholesterol content, the presence of a charge on the lipid bilayer, and the size of the vesicle, affect the effectiveness of liposomes as preventive and therapeutic agents [6]. Oral delivery of liposomal bacteriocins is a useful for the treatment to prevent dental caries [5]. Encapsulation technologies, which may shield substances such as nisin from degradation by digestive enzymes, and effectively deliver the encapsulated contents at the same time, could be an advancement in the field of preventive medicine [10].…”

Section: Introductionmentioning

confidence: 99%

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Prospects for Liposome-Encapsulated Nisin in the Prevention of Dental Caries

Tsumori

Shimizu²,

Nagatoshi³

et al. 2015

Interface Oral Health Science 2014

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Dental caries is a common oral bacterial infectious disease. Its prevention requires the control of the causative pathogens, such as Streptococcus mutans, that exist within dental plaque. Nisin is a proteinaceous bacteriocin produced by Lactococcus lactis that is used to suppress bacterial infections. It has an inhibitory mode of action on a wide range of gram-positive bacteria. Improvements in the medical benefits of antibacterial agents can be achieved if they can be retained in liposomes for a long period after administration. Liposome systems can increase the ability of the encapsulated compounds, which have been widely used to encapsulate many kinds of compounds in various scientific settings. Liposomes can release labile molecules at a moderate rate. Liposome technologies that effectively protect the encapsulated molecules from decomposition have the potential to improve their preventive and therapeutic effects. Therefore, the use of liposomes to administer antimicrobial agents has spurred research into their utility in preventive medicine. The encapsulation of nisin in liposomes can provide means of improving the stability of nisin and its antibacterial effect against S. mutans. The present chapter will review the prospects for liposome-encapsulated nisin for the prevention of oral infectious diseases.

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Sustainable inhibition efficacy of liposome-encapsulated nisin on insoluble glucan-biofilm synthesis byStreptococcus mutans

Cited by 48 publications

References 12 publications

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Lantibiotic Resistance

Prospects for Liposome-Encapsulated Nisin in the Prevention of Dental Caries

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