Sustainable Hybrid Route to Renewable Methacrylic Acid via Biomass-Derived Citramalate

Wu, Yuxiao; Shetty, Manish; Zhang, Kechun; Dauenhauer, Paul J.

doi:10.1021/acsengineeringau.1c00021

Cited by 10 publications

(9 citation statements)

References 54 publications

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“…Citramalate and 2-methylsuccinate are synthesized through the citramalate pathway using pyruvate and acetyl-CoA as starting materials. Citramalate, an organic compound, has the potential to serve as a precursor for methacrylate (MA), a crucial component in the production of polymers such as poly(methyl methacrylate) (PMMA) and styrene-methyl methacrylate (SMMA). , The use of biobased citramalate in the hybrid approach for MA synthesis has garnered significant attention due to its advantages over conventional chemical methods, primarily in terms of avoiding the formation of hazardous byproducts. , …”

Section: Overview Of C4 and C5 Dcasmentioning

confidence: 99%

“…60,61 The use of biobased citramalate in the hybrid approach for MA synthesis has garnered significant attention due to its advantages over conventional chemical methods, primarily in terms of avoiding the formation of hazardous byproducts. 62,63 In contrast, 2-methylsuccinate has various applications in the pharmaceutical industry and the production of biodegradable plastics. 64−66 Due to the harsh conditions and high costs associated with chemical synthesis, there has been a growing interest in exploring biobased approaches for its production.…”

Section: C4 and C5mentioning

confidence: 99%

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Recent Progress in Metabolic Engineering of Escherichia coli for the Production of Various C4 and C5-Dicarboxylic Acids

Moon

Jung

2023

J. Agric. Food Chem.

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As an alternative to petrochemical synthesis, well-established industrial microbes, such as Escherichia coli, are employed to produce a wide range of chemicals, including dicarboxylic acids (DCAs), which have significant potential in diverse areas including biodegradable polymers. The demand for biodegradable polymers has been steadily rising, prompting the development of efficient production pathways on four-(C4) and five-carbon (C5) DCAs derived from central carbon metabolism to meet the increased demand via the biosynthesis. In this context, E. coli is utilized to produce these DCAs through various metabolic engineering strategies, including the design or selection of metabolic pathways, pathway optimization, and enhancement of catalytic activity. This review aims to highlight the recent advancements in metabolic engineering techniques for the production of C4 and C5 DCAs in E. coli.

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Section: Overview Of C4 and C5 Dcasmentioning

confidence: 99%

Section: C4 and C5mentioning

confidence: 99%

Recent Progress in Metabolic Engineering of Escherichia coli for the Production of Various C4 and C5-Dicarboxylic Acids

Moon

Jung

2023

J. Agric. Food Chem.

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“…The sensor was proved to be remarkably selective and efficient. Significantly, considering that it has been recently demonstrated that it is possible to produce MAA from biomass-derived glucose, the manufacturing of this sensor can be considered potentially sustainable, as summarized in Figure 5 [ 113 ].…”

Section: Section A: Environmental Analysismentioning

confidence: 99%

Paving the Way for a Green Transition in the Design of Sensors and Biosensors for the Detection of Volatile Organic Compounds (VOCs)

et al. 2022

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The efficient and selective detection of volatile organic compounds (VOCs) provides key information for various purposes ranging from the toxicological analysis of indoor/outdoor environments to the diagnosis of diseases or to the investigation of biological processes. In the last decade, different sensors and biosensors providing reliable, rapid, and economic responses in the detection of VOCs have been successfully conceived and applied in numerous practical cases; however, the global necessity of a sustainable development, has driven the design of devices for the detection of VOCs to greener methods. In this review, the most recent and innovative VOC sensors and biosensors with sustainable features are presented. The sensors are grouped into three of the main industrial sectors of daily life, including environmental analysis, highly important for toxicity issues, food packaging tools, especially aimed at avoiding the spoilage of meat and fish, and the diagnosis of diseases, crucial for the early detection of relevant pathological conditions such as cancer and diabetes. The research outcomes presented in the review underly the necessity of preparing sensors with higher efficiency, lower detection limits, improved selectivity, and enhanced sustainable characteristics to fully address the sustainable manufacturing of VOC sensors and biosensors.

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“…[23][24][25][26][27] Another underutilized alkenoic acid is citraconic acid (V), mostly formed by isomerization of itaconic acid. [28][29][30][31][32] Unsaturated acids I-V are important in view of the possible derivatization of the C=C double bond to forge new CÀ C bonds. One of the most eco-sustainable approaches for the derivatization of biomass-derived compounds is through the implementation of photochemical/photocatalyzed strategies, [33] making use of traceless photons.…”

Section: Introductionmentioning

confidence: 99%

“…However, this acid may be also obtained by fungal fermentation (employing Rhizopus strains) of starch‐containing materials, glucose, xylose and lignocellulosic derivatives [23–27] . Another underutilized alkenoic acid is citraconic acid ( V ), mostly formed by isomerization of itaconic acid [28–32] …”

Section: Introductionmentioning

confidence: 99%

Photocatalyzed Functionalization of Alkenoic Acids in 3D‐Printed Reactors

et al. 2022

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The valorization of alkenoic acids possibly deriving from biomass (fumaric and citraconic acids) was carried out through conversion in important building blocks, such as γ‐keto acids and succinic acid derivatives. The functionalization was carried out by addition onto the C=C double bond of radicals generated under photocatalyzed conditions from suitable hydrogen donors (mainly aldehydes) and by adopting a decatungstate salt as the photocatalyst. Syntheses were performed under batch (in a glass vessel) and flow (by using 3D‐printed reactors) conditions. The design of the latter reactors allowed for an improved yield and productivity.

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Sustainable Hybrid Route to Renewable Methacrylic Acid via Biomass-Derived Citramalate

Abstract: Scheme 1. Hybrid fermentation and thermocatalysis to produce Methacrylic acid (MAA) from glucose through citramalic acid.

Cited by 10 publications

References 54 publications

Recent Progress in Metabolic Engineering of Escherichia coli for the Production of Various C4 and C5-Dicarboxylic Acids

Recent Progress in Metabolic Engineering of Escherichia coli for the Production of Various C4 and C5-Dicarboxylic Acids

Paving the Way for a Green Transition in the Design of Sensors and Biosensors for the Detection of Volatile Organic Compounds (VOCs)

Photocatalyzed Functionalization of Alkenoic Acids in 3D‐Printed Reactors

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