Sustainable Electrospun Poly(l-lactic acid) Fibers for Controlled Release of the Mosquito-Repellent Ethyl Butylacetylaminopropionate (IR3535)

Abstract

Fibers composed of poly(L-lactic acid) (PLLA) and the mosquito-repellent ethyl butylacetylaminopropionate (IR3535) were prepared by solution electrospinning. Defect-free and uniform monoaxial fibers with a diameter of the order of magnitude of 1 μm were obtained. Thermogravimetric analyses showed that it is possible to incorporate more than 40 m% of IR3535 into the PLLA fibers. Thermal and structural characterization indicated that IR3535 facilitates the crystallization of PLLA and formation of orthorhombic α-crystals during electrospinning. IR3535 has a plasticizing effect on PLLA, as detected by the decrease in the glass transition temperature. The release of IR3535 from PLLA/IR3535 fibers to the environment was quantified by thermogravimetric analysis at different temperatures ranging from 60 to 100 °C, suggesting rather slow evaporation of the repellent, with a time constant of few days at body temperature. The observed results indicate a possible use of electrospun PLLA/IR3535 fiber mats as part of a long-lasting repellent-delivery system and application in the field of combating diseases caused by mosquito bites.

Si̇vri̇si̇nek Kovucu Teksti̇l Malzemeleri̇ Üzeri̇ne Bi̇r Derleme

“…Du ve ark. [120], sivrisinek kovucu olarak bilinen sentetik IR3535 maddesi içeren PLLA nanolifli yüzeyler üretmişlerdir. IR3535'in PLLA/IR3535 nanolifli yüzeyinden çevreye salımı, 60 ile 100 °C arasındaki sıcaklıklarda termogravimetrik analizle ölçülmüştür.…”

Green synthesis of Eucalyptus globulus zinc nanoparticles and its use in antimicrobial insect repellent paint formulation in bulk industrial production

“…In addition, in Sudan, malaria is a primary cause of morbidity and mortality accounting for 7.5 million cases and 35,000 fatalities according to 12 months. The use of indoor residual spraying (IRS), and insecticide-handled bed nets (ITNs) are the number one strategy for lowering malarial vectors in Sudan [ [13] , [14] , [15] ]. There are number of techniques for the synthesis of materials that can be used for diverse industrial applications [ [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] ].…”