Sustainable Development Goals and the Future of Cardiovascular Health: A
                        Statement From the Global Cardiovascular Disease Taskforce

Zoghbi, William A.; Duncan, Tony; Antman, Elliott M.; Barbosa, Marcia; Champagne, Beatriz; Chen, Deborah; Gamra, Habib; Harold, John; Josephson, Staffan; Komajda, Michel; Løgstrup, Susanne; Mayosi, Bongani M.; Mwangi, Jeremiah; Ralston, Johanna; Sacco, Ralph L.; Sim, Kui Hian; Smith, Sidney C.; Vardas, Panos; Wood, David

doi:10.1016/j.gheart.2014.09.003

Cited by 36 publications

(30 citation statements)

References 1 publication

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“…Cardiovascular diseases are the major cause of death worldwide (WHO, ; Zoghbi et al, ). Cardiovascular diseases include all the pathologies related to heart and vessels.…”

Section: Introductionmentioning

confidence: 99%

Bioactive micropatterning of biomaterials for induction of endothelial progenitor cell differentiation: Acceleration of in situ endothelialization

Royer

Guay‐Bégin

Chanseau

et al. 2020

J Biomedical Materials Res

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Synthetic grafts do not provide an appealing surface for endothelial cells to adhere and colonize the inner surface. To promote in situ endothelialization the following aspect has to be taken into account, endothelial progenitor cells (EPCs) needs to be mobilized on the surface of the graft. The surface of the graft has to be sufficiently biocompatible to create a prone environment for the EPCs to adhere, proliferate and, differentiate to form a layer and subsequently improve graft patency. In this work, two active molecules GRGDS and sitagliptin, were chosen for their abilities to recruit, enhance adhesion and induce differentiation of endothelial progenitor cells. They were grafted on PET surfaces in order to provide restrained cues triggering cell alignment and evaluate the influence of such structuration on EPCs fate. We then analyze cell behavior onto functionalized biomaterials. Their abilities to control EPCs fate were demonstrated via RT-qPCR, immunofluorescence, and enzymatic tests. The GRGDS/sitagliptin 100 × 10 surface enables to reduce the stemness phenotype on EPCs and induce the expression of endothelial lineage markers. These results highlight the importance of spatial patterning cues in guiding EPCs organization and function, which may have clinical relevance in the development of vascular grafts that promote patency. K E Y W O R D S endothelial progenitor cells, endothelialization, in situ differentiation, peptides grafting, surface functionalization

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“…Cardiovascular diseases are the major cause of death worldwide (WHO, ; Zoghbi et al, ). Cardiovascular diseases include all the pathologies related to heart and vessels.…”

Section: Introductionmentioning

confidence: 99%

Bioactive micropatterning of biomaterials for induction of endothelial progenitor cell differentiation: Acceleration of in situ endothelialization

Royer

Guay‐Bégin

Chanseau

et al. 2020

J Biomedical Materials Res

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“…The increased prevalence of cardiovascular disease (CVD) in developing countries is placing a huge burden on health care services (1)(2)(3). India, in particular, with a large number of individuals with hypertension, dyslipidemia, diabetes and CVD, is facing a significant healthcare delivery challenge (4).…”

Section: Main Article [Word Count: 3519] Introductionmentioning

confidence: 99%

Cost-effectiveness of a fixed dose combination (polypill) in secondary prevention of cardiovascular diseases in India: Within-trial cost-effectiveness analysis of the UMPIRE trial

Singh

Crossan²,

Laba

et al. 2018

International Journal of Cardiology

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“…On a global scale, cardiovascular diseases were, are and will still be one of the leading cause of death for years to come [1]. Although dietary, lifestyle modifications and pharmaceutical intervention are prospective treatments for cardiovascular diseases, surgery is still considered the last resort and the most effective solution for severe cases [2].…”

Section: Introductionmentioning

confidence: 99%

Polyurethane/polycaprolactone membrane grafted with conjugated linoleic acid for artificial vascular graft application

Tran

et al. 2020

Science and Technology of Advanced Materials

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Constructing satisfied small-diameter vascular graft (diameter less than 6 mm) remains an unsolvable challenge in vascular tissue engineering. This study described the fabrication of electrospun polyurethane/polycaprolactone (PU/PCL) membranes chemically grafted with various densities of conjugated linoleic acid (CLA)an antithrombotic fatty acidfor making small-diameter blood vessel. Differences in mechanical, antithrombotic properties and biocompatibility of the membranes resulting from the CLA-grafting procedure were the focus of the study. Investigation of mechanical properties relevant to vascular graft application revealed that these properties of the membranes remained unaffected and satisfied clinical criteria following the CLA graft. Blood-membrane interaction assays showed that the CLA-grafted membranes mitigated the adhesion of blood cells, as well as preventing blood coagulation. These effects were also commensurate with increasing density of CLA, suggesting an effective approach to improve antithromboticity. Cellular tests suggested that CLA has an optimal density at which it promoted cell proliferation on the surface of the membranes; however, excessive presence of CLA might cause undesirable inhibition on cells. In conclusion, PU/PCL membrane grafted with CLA could be a prospective material for vascular tissue engineering with further development and investigation.

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Sustainable Development Goals and the Future of Cardiovascular Health: A Statement From the Global Cardiovascular Disease Taskforce

Cited by 36 publications

References 1 publication

Bioactive micropatterning of biomaterials for induction of endothelial progenitor cell differentiation: Acceleration of in situ endothelialization

Bioactive micropatterning of biomaterials for induction of endothelial progenitor cell differentiation: Acceleration of in situ endothelialization

Cost-effectiveness of a fixed dose combination (polypill) in secondary prevention of cardiovascular diseases in India: Within-trial cost-effectiveness analysis of the UMPIRE trial

Polyurethane/polycaprolactone membrane grafted with conjugated linoleic acid for artificial vascular graft application

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