Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines

Abstract

In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions.

Synthesis of alcohols: streamlined C1 to Cn hydroxyalkylation through photoredox catalysis

“…Mindful of the inherent challenges posed by batch photocatalytic methods at scale, our subsequent objective was to transition this hydroxyalkylation reaction to a continuous-flow platform. 46–48 Based on our expertise in microfluidic technology, 49–51 we identified some issues in the batch protocol that would hinder transitioning to a flow process. Firstly, the heterogeneous nature of the reaction mixture would result in non-uniform irradiation and limited light penetration when operating at larger scales.…”