Sustainable and smart keratin hydrogel with pH-sensitive swelling and enhanced mechanical properties

Ramos, María Luz Peralta; González, Joaquín; Fabián, Lucas; Pérez, Claudio Javier; Villanueva, María Emilia; Copello, Guillermo Javier

doi:10.1016/j.msec.2017.04.120

Cited by 48 publications

(18 citation statements)

References 36 publications

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“…In this way, the mechanical properties are improved through sealing parts of the side groups on the macromolecular chains, thus increasing the average molecular weight of the keratin during regeneration, or adjusting the arrangement of the molecules. This method has the advantage of being able to prepare pure regenerated keratin material that retains many of the excellent properties of keratin [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Yang

Niu

et al. 2018

Polymers

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Much research has focused on improvement of the structural and mechanical properties of regenerated keratin materials by physical or chemical methods in recent years. In this research, regenerated keratin materials were modified with graphene oxide (GO). The properties of modified keratin films and the mechanism of interaction between GO and keratin macromolecules were studied. The SEM and XRD test results showed that the orientation of keratin macromolecules could be effectively improved by GO, which favored improvement of the keratin material’s crystallinity and made the films more uniform and compact. The thermal stability and mechanical properties of GO-modified keratin films were also improved significantly. At the same time, the reaction mechanism between keratin and GO materials was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), FT-IR, and Raman spectroscopy. It was shown that there was no chemical reaction between GO and keratin molecules, and the interaction between them was mainly via hydrogen bonding and van der Waals forces.

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Section: Introductionmentioning

confidence: 99%

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Yang

Niu

et al. 2018

Polymers

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“…In many of these examples, keratin has been combined with itaconic acid, N-isopropyl acrylamide, or methacrylic acid to achieve pH responsiveness [ [118] , [119] , [120] ]. More recently, Peralta Ramos et al reported a stimulus-responsive hydrogel that did not depend on chemical grafting to achieve its mechanical properties and pH-responsivity [ 121 ]. This was credited to a novel synthesis strategy during which disulfide bridges were broken and the α-keratin reorganized.…”

Section: Applications In Drug Deliverymentioning

confidence: 99%

“…At an acidic pH, the carboxyl groups were protonated and formed hydrogen bonds, which created a higher fraction of β-sheet conformations and kept the gel in a collapsed state. At a basic pH, hydrogen bonds broke to create more sites for water adsorption, thus forcing chain reorganization and allowing the material to swell [ 121 ]. Villanueva et al expanded upon this work by incorporating antimicrobial ZnO nanoplates into the pH-responsive hydrogel [ 122 ].…”

Section: Applications In Drug Deliverymentioning

confidence: 99%

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

Varanko

Saha

Chilkoti

2020

Advanced Drug Delivery Reviews

191

120

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Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials —naturally derived, chemically synthesized and recombinant— with a focus on the molecular features that modulate their structure-function relationships for drug delivery.

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“…Hydrogels are water-swollen polymeric materials that maintain a distinct three-dimensional structure [19]. They have been explored for a variety of biological applications, such as regenerative medicine, drug delivery, stem cell and cancer research, as well as wound dressing, due to their tunable physical, chemical, and biological properties, high biocompatibility, ease of fabrication, and similarity to native extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

A pH-Indicating Colorimetric Tough Hydrogel Patch towards Applications in a Substrate for Smart Wound Dressings

Liu

Nagao

et al. 2017

Polymers

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Abstract:The physiological milieu of healthy skin is slightly acidic, with a pH value between 4 and 6, whereas for skin with chronic or infected wounds, the pH value is above 7.3. As testing pH value is an effective way to monitor the status of wounds, a novel smart hydrogel wound patch incorporating modified pH indicator dyes was developed in this study. Phenol red (PR), the dye molecule, was successfully modified with methacrylate (MA) to allow a copolymerization with the alginate/polyacrylamide (PAAm) hydrogel matrix. This covalent attachment prevented the dye from leaching out of the matrix. The prepared pH-responsive hydrogel patch exhibited a porous internal structure, excellent mechanical property, and high swelling ratio, as well as an appropriate water vapour transmission rate. Mechanical responses of alginate/P(AAm-MAPR) hydrogel patches under different calcium and water contents were also investigated to consider the case of exudate accumulation into hydrogels. Results showed that increased calcium amount and reduced water content significantly improved the Young's modulus and elongation at break of the hydrogels. These characteristics indicated the suitability of hydrogels as wound dressing materials. When pH increased, the color of the hydrogel patches underwent a transition from yellow (pH 5, 6 and 7) to orange (7.4 and 8), and finally to red (pH 9). This range of color change matches the clinically-meaningful pH range of chronic or infected wounds. Therefore, our developed hydrogels could be applied as promising wound dressing materials to monitor the wound healing process by a simple colorimetric display, thus providing a desirable substrate for printed electronics for smart wound dressing.

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Sustainable and smart keratin hydrogel with pH-sensitive swelling and enhanced mechanical properties

Cited by 48 publications

References 36 publications

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Effects of Graphene Oxide on the Structure and Properties of Regenerated Wool Keratin Films

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

A pH-Indicating Colorimetric Tough Hydrogel Patch towards Applications in a Substrate for Smart Wound Dressings

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