“…On this basis, we focused on the use of these solvents for the total synthesis of dimethindene ( 6 ). Moreover, to quantify the eco-sustainability of the synthesis of 6 , when using 2-MeTHF or CPME as the solvent, we made use of the First Pass CHEM21 Metrics Toolkit developed by Clark et al [ 33 , 34 , 35 ], calculating atom economy (AE), reaction mass efficiency (RME), optimum efficiency (OE), effective mass yield (EM), and mass intensity (MI) of each step, along with process mass intensity (PMI) metrics, the latter taking into account the reactants, reagents, and solvents of the whole process (PMI RXN ) or the solvents and reagents used in the work-up procedure (PMI WU ), and we compared these values with the corresponding ones related to the classical synthetic procedure for 6 (see Supplementary Materials for details). In addition, some metrics typical of the Second Pass CHEM21 Metrics Toolkit, which quantify the use of material from renewable sources, such as renewables intensity (RI) and renewables percentage (RP), were also calculated.…”