The essence of infrastructure development within the context of the health sector is gaining popularity in both developed and developing countries, especially in Africa. A growing interest in infrastructure development has been witnessed after the emergence of the COVID-19 health crisis which exposed infrastructure development deficiency in many developing countries. As such, infrastructure development is a key factor in universal health coverage, higher productivity, and socio-economic transformation. Interestingly, reliable infrastructure is at the heart of attaining sustainable development goals (SDGs) as it connects supply chains. However, there is sparse knowledge about infrastructure development strategies in the health sectors, especially after the outbreak COVID-19 pandemic. Therefore, this chapter aims to unpack the infrastructure development strategies in the health sector towards the 2030 agenda for sustainable development. The outcomes of this research will be of great value to health professionals, scholars, and policymakers.