Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy

Cartier, V.; Crouan, Anne; Esvan, Maxime; Oberti, Frédéric; Michalak, Sophie; Gallix, B.; Séror, Olivier; Pathil, Anita; Vilgrain, Valérie; Aubé, Christophe; Anty, Rodolphe; Archambeaud, Isabelle; Baudin, G.; Brun, Vanessa; Chevallier, P.; Cuilleron, Muriel; Dumortie, J.; Duvoux, Christophe; Estivalet, L.; Frampas, É.; Gandon, Y.; Guillygomarc’h, Anne; Guiu, Boris; Lebigot, J.; Pennéc, V. Le; Luciani, Alain; Minello, Anne; Ollivier-Hourmand, Isabelle; Pilleul, F.; Patouillard, Brigitte; Sylvain, Christine; Tasu, J.P.

doi:10.1016/j.diii.2017.12.014

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…And in patients with malignancies, the invasive biopsy procedure may lead to needle tract seeding and metastases [ 27 ]. The potential damage mentioned above would inevitably affect patients’ acceptance to invasive procedures, particularly in some longitudinal studies that require repeated sampling [ 28 , 29 ]. Since the limited specimen could not always be fully representative of the entire pathological tissue, especially in tumor lesion which is highly heterogeneous [ 30 ], great attention should be taken on the accuracy of tissue sampling.…”

Section: The Development Of Pathologymentioning

confidence: 99%

Transpathology: molecular imaging-based pathology

Tian

Jin

et al. 2021

Eur J Nucl Med Mol Imaging

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Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the management of patients. However, challenges facing pathology, the inherent invasiveness of pathological practice and the persistent concerns on the sample representativeness, constitute its limitations. Molecular imaging is a noninvasive technique to visualize, characterize, and measure biological processes at the molecular level in living subjects. With the continuous development of equipment and probes, molecular imaging has enabled an increasingly precise evaluation of pathophysiological changes. A new pathophysiology visualization system based on molecular imaging is forming and shows the great potential to reform the pathological practice. Several improvements in “trans-,” including trans-scale, transparency, and translation, would be driven by this new kind of pathological practice. Pathological changes could be evaluated in a trans-scale imaging mode; tissues could be transparentized to better present the underlying pathophysiological information; and the translational processes of basic research to the clinical practice would be better facilitated. Thus, transpathology would greatly facilitate in deciphering the pathophysiological events in a multiscale perspective, and supporting the precision medicine in the future.

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Section: The Development Of Pathologymentioning

confidence: 99%

Transpathology: molecular imaging-based pathology

Tian

Jin

et al. 2021

Eur J Nucl Med Mol Imaging

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show abstract

“…70 A biopsy should be performed for indeterminate or suspicious lesions without hallmark characteristics for definitive diagnosis. 71 In patients with nonvascular cirrhosis or chronic HBV per LI-RAD algorithm, regenerative and dysplastic nodules are characterized as LI-RAD-3, intermediate probability lesions, and repeat or an alternative diagnostic imaging is recommended in 3 to 6 months. When upscaled to a LI-RAD 4, probably HCC, biopsy is recommended.…”

Section: Treatmentmentioning

confidence: 99%

Minimally Invasive Image-Guided Procedures for Benign Liver Lesions

Khan

Nezami

Stumpf

et al. 2023

Digestive Disease Interventions

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As access to affordable high-resolution medical imaging has improved, so too has the identification of benign hepatic lesions. Advanced imaging techniques and applications often allow characterization of these lesions so as to differentiate benign and malignant lesions without the need for biopsy. Patients with benign liver lesions are usually asymptomatic; however, a palliative intervention may be indicated if a benign liver lesion is symptomatic. This article reviews the characteristic imaging features of benign liver lesions, the indications for minimally invasive intervention, and the specific procedures for minimally invasive, nonsurgical intervention, and the procedural expectations, effectiveness, and periprocedural care.

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“…Consequently, LB has a diagnostic yield exceeding 91% [ 18 , 19 , 20 ], with the accuracy rate of LB increasing with the pre-test imaging probability provided by the LiRADS system [ 18 ]. These figures appear not to differ substantially depending on technique (coaxial vs. non-coaxial core biopsy) [ 21 ] or timing (first vs. second biopsy after initial non-diagnostic LB) [ 22 ]. Not least, even fine-needle aspiration cytology has acceptable accuracy (>80%), with the advantage of using significantly thinner needles [ 23 ].…”

Section: Past and Present: A Biopsy For A Positive Diagnosis In Clini...mentioning

confidence: 99%

Refining Liver Biopsy in Hepatocellular Carcinoma: An In-Depth Exploration of Shifting Diagnostic and Therapeutic Applications

Spârchez,

Crăciun,

Nenu

et al. 2023

Biomedicines

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The field of hepatocellular carcinoma (HCC) has faced significant change on multiple levels in the past few years. The increasing emphasis on the various HCC phenotypes and the emergence of novel, specific therapies have slowly paved the way for a personalized approach to primary liver cancer. In this light, the role of percutaneous liver biopsy of focal lesions has shifted from a purely confirmatory method to a technique capable of providing an in-depth characterization of any nodule. Cancer subtype, gene expression, the mutational profile, and tissue biomarkers might soon become widely available through biopsy. However, indications, expectations, and techniques might suffer changes as the aim of the biopsy evolves from providing minimal proof of the disease to high-quality specimens for extensive analysis. Consequently, a revamped position of tissue biopsy is expected in HCC, following the reign of non-invasive imaging-only diagnosis. Moreover, given the advances in techniques that have recently reached the spotlight, such as liquid biopsy, concomitant use of all the available methods might gather just enough data to improve therapy selection and, ultimately, outcomes. The current review aims to discuss the changing role of liver biopsy and provide an evidence-based rationale for its use in the era of precision medicine in HCC.

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Suspicious liver nodule in chronic liver disease: Usefulness of a second biopsy

Abstract: The diagnostic yield of a second biopsy of a suspicious lesion suggestive of HCC in chronic liver disease is not decreased compared to the first one. Repeated biopsy after a first negative one could be an alternative option to the follow-up of patients with chronic liver disease.

Cited by 14 publications

References 19 publications

Transpathology: molecular imaging-based pathology

Transpathology: molecular imaging-based pathology

Minimally Invasive Image-Guided Procedures for Benign Liver Lesions

Refining Liver Biopsy in Hepatocellular Carcinoma: An In-Depth Exploration of Shifting Diagnostic and Therapeutic Applications

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