Suspension pellet layering using PVA–PEG graft copolymer as a new binder

Suhrenbrock, Lisa; Radtke, Guido; Knop, Klaus; Kleinebudde, Peter

doi:10.1016/j.ijpharm.2011.03.061

Cited by 23 publications

(8 citation statements)

References 4 publications

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“…The outcomes of various studies on these materials have established that the dispersion of MMT in the PVA, PVP, PEO, and PEG matrices improves their mechanical, thermal, gas permeable and dielectric/electrical properties. The research work on the PVA blends with PVP, PEO, and PEG also confirms the enhancement in their technological and industrial important physicochemical properties as compared with the individual polymer. These improved properties of the polymers blends depend on the miscibility and the heteromolecular interaction compatibility generated between the functional groups of the polymers.…”

Section: Introductionsupporting

confidence: 58%

“…The d 001 and W cg values, recorded in Table , confirm that the intercalated structures of PVA− x wt % MMT nanocomposites expand the 001 basal plane spacing of MMT comparable to that of the double layers accommodated PEG− x wt % MMT nanocomposites . Therefore, the study of the nanocomposites based on the PVA−PEG blend dispersed with MMT nanofiller has an importance in regards to confirmation of this polymer blend on the crystallization behavior and in the enhancement of their pharmaceutical and technological applications …”

Section: Resultsmentioning

confidence: 62%

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Structural characterization of hydrophilic polymer blends/montmorillonite clay nanocomposites

Sengwa

Choudhary

2014

J of Applied Polymer Sci

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The nanocomposite films comprising polymer blends of poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP), poly(ethylene oxide) (PEO), and poly(ethylene glycol) (PEG) with montmorillonite (MMT) clay as nanofiller were prepared by aqueous solution casting method. The X‐ray diffraction studies of the PVA–x wt % MMT, (PVA–PVP)–x wt % MMT, (PVA–PEO)–x wt % MMT and (PVA–PEG)–x wt % MMT nanocomposites containing MMT concentrations x = 1, 2, 3, 5 and 10 wt % of the polymer weight were carried out in the angular range (2θ) of 3.8–30°. The values of MMT basal spacing d001, expansion of clay gallery width Wcg, d‐spacing of polymer spherulite, crystallite size L and diffraction peak intensity I were determined for these nanocomposites. The values of structural parameters reveal that the linear chain PEO and PEG in the PVA blend based nanocomposites promote the amount of MMT intercalated structures, and these structures are found relatively higher for the (PVA–PEO)–x wt % MMT nanocomposites. It is observed that the presence of bulky ester‐side group in PVP backbone restricts its intercalation, whereas the adsorption behavior of PVP on the MMT nanosheets mainly results the MMT exfoliated structures in the (PVA–PVP)–x wt % MMT nanocomposites. The crystallinities of the PEO and PEG were found low due to their blending with PVA, which further decreased anomalously with the increase of MMT concentration in the nanocomposites. The decrease of polymer crystalline phase of these materials confirmed their suitability in preparation of novel solid polymer nanocomposite electrolytes. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40617.

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Section: Introductionsupporting

confidence: 58%

Section: Resultsmentioning

confidence: 62%

Structural characterization of hydrophilic polymer blends/montmorillonite clay nanocomposites

Sengwa

Choudhary

2014

J of Applied Polymer Sci

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“…HCT layered pellets (hydrochlorothiazide layered on Cellets Ò 500 (IPC, Dresden, Germany) [37]) (Fig. 1c) black curve) or theophylline pellets (Temmler Ireland Ltd., Killorglin, Co Kerry, Ireland) ( Fig.…”

Section: Core and Coating Materialsmentioning

confidence: 99%

In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes

Folttmann

Knop

Kleinebudde

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

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“…In the past decades, biodegradable materials have received considerable attention as a result of the growing environmental concerns of non-biodegradable materials. [1][2][3][4] Of these materials, poly(vinyl alcohol) (PVA) is a highly biocompatible, nontoxic synthetic polymer with high water solubility resulting from the hydroxyl groups in its side chain, 5 and it has been applied in medical, 6 membrane manufacturing, 7 food, 8 and so on. However, the high hydrophilicity makes PVA sensitive to moisture, which decreases its mechanical properties and thus limits its application scope in living environments.…”

Section: Introductionmentioning

confidence: 99%

Non-covalently functionalized multiwalled carbon nanotubes by chitosan and their synergistic reinforcing effects in PVA films

Huang

Wang

2013

RSC Adv.

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Multiwalled carbon nanotubes (MWCNTs) were regarded as ideal candidates for fillers in a polymer matrix due to their outstanding mechanical, electrical and thermal properties. A series of nanocomposite films were prepared by a solution casting method introducing chitosan (CS) treated MWCNTs into a poly (vinyl alcohol) (PVA) matrix. The nanocomposites were characterized by field emission scanning electron microscopy and Fourier Transform Infrared Spectroscopy. The results indicated that MWCNTs treated by chitosan dispersed well in the PVA matrix, and the tensile properties and water resistance of nanocomposites were improved greatly compared with neat PVA.

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Suspension pellet layering using PVA–PEG graft copolymer as a new binder

Cited by 23 publications

References 4 publications

Structural characterization of hydrophilic polymer blends/montmorillonite clay nanocomposites

Structural characterization of hydrophilic polymer blends/montmorillonite clay nanocomposites

In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes

Non-covalently functionalized multiwalled carbon nanotubes by chitosan and their synergistic reinforcing effects in PVA films

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