The scientific understanding regarding sources, occurrence, and effects of microplastics in the aquatic environment has advanced rapidly, leaving some meaningful knowledge gaps virtually untouched. One of them is the interactions of microplastics and biofilms, microbial communities ubiquitous in aquatic ecosystems and fundamental for a range of ecosystem level processes. It is evident that biofilms can quickly develop on microplastics' surface and consequently change particle properties and as such its fate and ecotoxicity. Moreover, microplastics interact with ubiquitous biofilms that are developed on any surfaces in aquatic ecosystems.