Gas sensing and fluid-guiding response properties of a suspended core fiber Raman analyzer with side-opened and strut microfluid-guiding array are explored. A Raman sensing model is introduced for effective mode area optimization and normalized intensity overlap enhancement between Raman sensing light and analyte. Calculations predict that there is a trade-off between the overlap and the effective mode area, while the optimal trade-off depends on the refractive index of the background material, core diameter, and strut's thickness. Furthermore, the multi-opened-up structure ensures a fast gases diffusing into/out of each hole for real-time Raman sensing. Simulation results confirm a limited gas sensing response time of less than 6 s could be feasible and, thus, a new approach to real-time gas sensing applications is identified.