Suspended animation, diapause and quiescence

Padilla, Pamela A.; Ladage, Mary L.

doi:10.4161/cc.19444

Cited by 49 publications

(23 citation statements)

References 52 publications

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“…Alternatively, some aspects of aging may occur, with some damage accumulating, but these aging hallmarks could be “reset” at the exit from diapause, as has been shown for C. elegans (Klass & Hirsh, 1976; Roux, Langhans, Huynh & Kenyon, 2016). Second, it is important to note that, at least in C. elegans , the genetic network underlying the dauer state shares many components with the genetic network of aging, with notably a key role for the insulin pathway (Antebi, 2013; Fielenbach & Antebi, 2008; Girard et al., 2007; Padilla & Ladage, 2012). …”

Section: Using the African Turquoise Killifish As A Research Organismmentioning

confidence: 99%

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Brunet²

2018

Aging Cell

135

118

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SummaryThe African turquoise killifish has recently gained significant traction as a new research organism in the aging field. Our understanding of aging has strongly benefited from canonical research organisms—yeast, C. elegans, Drosophila, zebrafish, and mice. Many characteristics that are essential to understand aging—for example, the adaptive immune system or the hypothalamo‐pituitary axis—are only present in vertebrates (zebrafish and mice). However, zebrafish and mice live more than 3 years and their relatively long lifespans are not compatible with high‐throughput studies. Therefore, the turquoise killifish, a vertebrate with a naturally compressed lifespan of only 4–6 months, fills an essential gap to understand aging. With a recently developed genomic and genetic toolkit, the turquoise killifish not only provides practical advantages for lifespan and longitudinal experiments, but also allows more systematic characterizations of the interplay between genetics and environment during vertebrate aging. Interestingly, the turquoise killifish can also enter a long‐term dormant state during development called diapause. Killifish embryos in diapause already have some organs and tissues, and they can last in this state for years, exhibiting exceptional resistance to stress and to damages due to the passage of time. Understanding the diapause state could give new insights into strategies to prevent the damage caused by aging and to better preserve organs, tissues, and cells. Thus, the African turquoise killifish brings two interesting aspects to the aging field—a compressed lifespan and a long‐term resistant diapause state, both of which should spark new discoveries in the field.

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Section: Using the African Turquoise Killifish As A Research Organismmentioning

confidence: 99%

The African turquoise killifish: A research organism to study vertebrate aging and diapause

Brunet²

2018

Aging Cell

135

118

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“…For example, tissues can decrease turnover and/or scale down their overall size when the nutrients are limited123. Stem cells are widely considered the master regulators of tissue homeostasis, and how stem cells respond to changes in their external environment has been heavily studied456.…”

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confidence: 99%

spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis

Chiang

Yang

Yamashita

2017

Sci Rep

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Tissues are maintained in a homeostatic state by balancing the constant loss of old cells with the continued production of new cells. Tissue homeostasis can shift between high and low turnover states to cope with environmental changes such as nutrient availability. Recently, we discovered that the elimination of transit-amplifying cells plays a critical role in maintaining the stem cell population during protein starvation in the Drosophila testis. Here, we identify spict, a gene expressed specifically in differentiating cyst cells, as a regulator of spermatogonial death. Spict is upregulated in cyst cells that phagocytose dying spermatogonia. We propose that phagocytosis and subsequent clearance of dead spermatogonia, which is partly promoted by Spict, contribute to stem cell maintenance during prolonged protein starvation.

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“…Because it is an attractive model for hypoxia research we have built a framework of hypoxia responses as a function of O 2 tension using C. elegans , drawing connections with other systems when possible. There have been several excellent reviews recently about signaling pathways that coordinate cellular responses to hypoxia (Gorr et al, 2006; Powell-Coffman, 2010; Hand et al, 2011; Padilla and Ladage, 2012). In this review we compare how strategies to respond to hypoxia vary with O 2 concentration, and focus on how response mechanisms could integrate with other signaling pathways to influence organism physiology and lifespan.…”

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confidence: 99%

Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling

Iranon¹,

Miller²

2012

Front. Gene.

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The ability to sense and respond to stressful conditions is essential to maintain organismal homeostasis. It has long been recognized that stress response factors that improve survival in changing conditions can also influence longevity. In this review, we discuss different strategies used by animals in response to decreased O2 (hypoxia) to maintain O2 homeostasis, and consider interactions between hypoxia responses, nutritional status, and H2S signaling. O2 is an essential environmental nutrient for almost all metazoans as it plays a fundamental role in development and cellular metabolism. However, the physiological response(s) to hypoxia depend greatly on the amount of O2 available. Animals must sense declining O2 availability to coordinate fundamental metabolic and signaling pathways. It is not surprising that factors involved in the response to hypoxia are also involved in responding to other key environmental signals, particularly food availability. Recent studies in mammals have also shown that the small gaseous signaling molecule hydrogen sulfide (H2S) protects against cellular damage and death in hypoxia. These results suggest that H2S signaling also integrates with hypoxia response(s). Many of the signaling pathways that mediate the effects of hypoxia, food deprivation, and H2S signaling have also been implicated in the control of lifespan. Understanding how these pathways are coordinated therefore has the potential to reveal new cellular and organismal homeostatic mechanisms that contribute to longevity assurance in animals.

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Suspended animation, diapause and quiescence

Cited by 49 publications

References 52 publications

The African turquoise killifish: A research organism to study vertebrate aging and diapause

The African turquoise killifish: A research organism to study vertebrate aging and diapause

spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis

Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling

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