Suspected Local Recurrence after Radical Prostatectomy: Endorectal Coil MR Imaging

Sella, Tamar; Schwartz, Lawrence H.; Swindle, Peter; Onyebuchi, Chinyere N.; Scardino, Peter T.; Scher, Howard I.; Hricak, Hedvig

doi:10.1148/radiol.2312030011

Cited by 272 publications

(149 citation statements)

References 27 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…MR imaging is considered a valid tool in evaluating patients with suspected local recurrence. MR imaging is also the most accurate for clearly defining the morphology of the local recurrence, in terms of size, location, and relationship to critical structures such as sphincters (14). With the increasing use of more focused, salvage therapies in locally recurrent prostate cancer, …”

Section: Discussionmentioning

confidence: 99%

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

et al. 2014

View full text Add to dashboard Cite

The aim of this study was to compare 11 C-choline PET/CT with pelvic multiparametric MR imaging for detection of recurrent prostate carcinoma in patients with suspected recurrence after radical prostatectomy and to identify an optimal imaging method to restage these patients. Methods: This was a retrospective, single-institution study of 115 prostatectomy patients with suspected tumor recurrence who underwent both 11 C-choline PET/CT and multiparametric MR imaging with endorectal coil. The reference standard included histopathology, treatment change, and imaging follow-up for determination of locally recurrent tumor, lymph node (LN) metastases, and skeletal metastases. Two nuclear medicine and 2 genitourinary radiologists independently and in a masked manner reviewed PET/ CT and multiparametric MR imaging, respectively. The reviewers assessed for local recurrence in the prostatectomy bed as well as LN and bone metastases, rating their diagnostic confidence with a 5-point scoring system for each location. Receiver-operatingcharacteristic analysis was used to compare the 2 modalities. Results: The standard of reference (either positive or negative) for the diagnosis of local recurrence and pelvic LN and bone metastases was met in 87, 70, and 95 patients, respectively. Documented local recurrence and pelvic LN and bone metastases was present in 61 of 87 (70.1%), 50 of 70 (71.4%), and 16 of 95 (16.8%) patients, respectively. Patient-based area under the receiver-operatingcharacteristic curves of multiparametric MR imaging versus PET/ CT for the diagnosis of local recurrence and pelvic LN and bone metastases were 0.909 versus 0.761 (P 5 0.0079), 0.812 versus 0.952 (P 5 0.0064), and 0.927 versus 0.898 (P 5 0.69), respectively. Among 61 patients with local recurrence, 32 patients (52.4%) were correctly diagnosed as having local recurrence by both multiparametric MR imaging and PET/CT, 22 (36.1%) were correctly diagnosed by multiparametric MR imaging only, 6 (9.8%) could not be diagnosed by either modality, and 1 (1.6%) was correctly diagnosed by PET/CT only. The patient-based sensitivity, specificity, and accuracy of multiparametric MR imaging for diagnosing local recurrence were 88.5% (54/61), 84.6% (22/26), and 87.4% (76/87) whereas those of PET/CT for detecting body LN or bone metastases were 92.3% (72/78), 100% (18/18), and 93.8% (90/96), respectively. Conclusion: Multiparametric MR imaging with endorectal coil is superior for the detection of local recurrence, PET/CT is superior for pelvic LN metastasis, and both were equally excellent for pelvic bone metastasis. 11 C-choline PET/CT and pelvic multiparametric MR imaging are complementary for restaging prostatectomy patients with suspected recurrent disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In a single-centre retrospective study Sella et al [40] analysed 48 patients with biochemical progression after RP. All patients were submitted to endorectal coil MRI to investigate the presence of a local recurrence of PC.…”

Section: Multiparametric Mrimentioning

confidence: 99%

Comparative analysis of multiparametric magnetic resonance and PET-CT in the management of local recurrence after radical prostatectomy for prostate cancer

Alfarone

Panebianco

Schillaci

et al. 2012

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Purpose\ud \ud Our aim was to assess whether multiparametric magnetic resonance and PET-CT can have a role in detecting local recurrence in patients with biochemical recurrence after radical prostatectomy.\ud \ud Methods\ud \ud We reviewed the recent international literature by carrying out a PUBMED search.\ud \ud Results\ud \ud We critically reviewed 11 recent original studies about the use of PET-CT and 5 recent studies about the use of multiparametric magnetic resonance. PET-CT has not shown significant results in terms of detection rate for local recurrence in patients with low level of PSA. Multiparametric magnetic resonance showed encouraging results to detect local recurrence in patients with low PSA and with small diameter lesions.\ud \ud Conclusions\ud \ud Currently, most important urological societies do not consider multiparametric magnetic resonance and PET-CT in the follow-up of patients with suspected local recurrence after radical prostatectomy. We can assert that multiparametric magnetic resonance seems to have excellent results in detecting local recurrence in patients submitted to radical prostatectomy and PSA < 1.5 ng/ml

show abstract

“…elevated PSA levels but negative biopsy), MRI may be used to detect and direct re-biopsy of suspected tumour foci [4]. When tumour recurrence is suspected, MRI can aid in localising the site of tumour recurrence [5].…”

Section: Clinical Application Of Mri In Localised Prostate Cancermentioning

confidence: 99%

Diffusion weighted imaging in prostate cancer

2010

View full text Add to dashboard Cite

Diffusion-weighted imaging has generated substantial interest in the hope that it can be developed into a robust technique to improve the accuracy of MRI for the evaluation of prostate cancer. This technique has the advantages of short acquisition times, no need for intravenous administration of contrast medium, and the ability to study diffusion of water molecules that indirectly reflects tissue cellularity. In this article, we review the existing literature on the utility of DWI in tumour detection, localisation, treatment response, limitations of the technique, how it compares with other imaging techniques, technical considerations and future directions.

show abstract

Suspected Local Recurrence after Radical Prostatectomy: Endorectal Coil MR Imaging

Abstract: MR imaging depicts a high proportion of local recurrence after prostatectomy. The authors propose incorporation of endorectal coil MR imaging in the diagnostic paradigm of patients who have undergone prostatectomy and are suspected of having local recurrence.

Cited by 272 publications

References 27 publications

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

Comparative analysis of multiparametric magnetic resonance and PET-CT in the management of local recurrence after radical prostatectomy for prostate cancer

Diffusion weighted imaging in prostate cancer

Contact Info

Product

Resources

About

Suspected Local Recurrence after Radical Prostatectomy: Endorectal Coil MR Imaging

Abstract: MR imaging depicts a high proportion of local recurrence after prostatectomy. The authors propose incorporation of endorectal coil MR imaging in the diagnostic paradigm of patients who have undergone prostatectomy and are suspected of having local recurrence.

Cited by 272 publications

References 27 publications

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of 11C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of 11C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

Comparative analysis of multiparametric magnetic resonance and PET-CT in the management of local recurrence after radical prostatectomy for prostate cancer

Diffusion weighted imaging in prostate cancer

Contact Info

Product

Resources

About

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil

Detection of Recurrent Prostate Cancer After Radical Prostatectomy: Comparison of ¹¹C-Choline PET/CT with Pelvic Multiparametric MR Imaging with Endorectal Coil