Suspected congenital generalised tuberculosis in a newborn calf

Özyiğit, M. Özgür; Şentürk, Senem; Akkoç, Ahmet

doi:10.1136/vr.160.9.307

Cited by 16 publications

(17 citation statements)

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“…Young camels can also be easily infected with higher doses of mycobacteria via colostrums from infected camel in a similar way, as it occurs in cattle [29]. In connection with this, another report mentioned of vertical transmission of M. bovis from an infected dam to her calf through congenital infection in utero [30]. It was observed that lesion was more frequently observed in female camels as compared to male camels.…”

Section: Discussionmentioning

confidence: 88%

Pathology of Camel Tuberculosis and Molecular Characterization of Its Causative Agents in Pastoral Regions of Ethiopia

et al. 2011

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A cross sectional study was conducted on 906 apparently healthy camels slaughtered at Akaki and Metehara abattoirs to investigate the pathology of camel tuberculosis (TB) and characterize its causative agents using postmortem examination, mycobacteriological culturing, and multiplex polymerase chain reaction (PCR), region of difference-4 (RD4)-based PCR and spoligotyping. The prevalence of camel TB was 10.04% (91/906) on the basis of pathology and it was significantly higher in females (χ2 = 4.789; P = 0.029). The tropism of TB lesions was significantly different among the lymph nodes (χ2 = 22.697; P = 0.002) and lung lobes (χ2 = 17.901; P = 0.006). Mycobacterial growth was observed in 34% (31/91) of camels with grossly suspicious TB lesions. Upon further molecular characterization using multiplex PCR, 68% (21/31) of the colonies showed a positive signal for the genus Mycobacterium, of which two were confirmed Mycobacterium bovis (M. bovis) by RD4 deletion typing. Further characterization of the two M. bovis at strains level revealed that one of the strains was SB0133 while the other strain was new and had not been reported to the M. bovis database prior to this study. Hence, it has now been reported to the database, and designated as SB1953. In conclusion, the results of the present study have shown that the majority of camel TB lesions are caused by mycobacteria other than Mycobacterium tuberculosis complex. And hence further identification and characterization of these species would be useful towards the efforts made to control TB in camels.

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Section: Discussionmentioning

confidence: 88%

Pathology of Camel Tuberculosis and Molecular Characterization of Its Causative Agents in Pastoral Regions of Ethiopia

et al. 2011

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“…The low number of positive cases in young animals may be associated with the predominance of gamma delta (γδ) T cells in calves that have been shown to play a relevant role in antimycobacterial immunity [27]. The positive calves (although in low number) could be due to congenital transmission in utero [28]. In addition, ingestion of contaminated colostrum has already been reported as another route of bTB transmission [29], as well as pseudo-vertical transmission (close contact between cow and its calf) [30].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Bovine Tuberculosis and Risk Factor Assessment in Cattle in Rural Livestock Areas of Govuro District in the Southeast of Mozambique

et al. 2014

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BackgroundBovine tuberculosis (bTB), caused by Mycobacterium bovis, is an infectious disease of cattle that also affects other domestic animals, free-ranging and farmed wildlife, and also humans. In Mozambique, scattered surveys have reported a wide variation of bTB prevalence rates in cattle from different regions. Due to direct economic repercussions on livestock and indirect consequences for human health and wildlife, knowing the prevalence rates of the disease is essential to define an effective control strategy.Methodology/Principal findingsA cross-sectional study was conducted in Govuro district to determine bTB prevalence in cattle and identify associated risk factors. A representative sample of the cattle population was defined, stratified by livestock areas (n = 14). A total of 1136 cattle from 289 farmers were tested using the single comparative intradermal tuberculin test. The overall apparent prevalence was estimated at 39.6% (95% CI 36.8–42.5) using a diagnostic threshold cut-off according to the World Organization for Animal Health. bTB reactors were found in 13 livestock areas, with prevalence rates ranging from 8.1 to 65.8%. Age was the main risk factor; animals older than 4 years were more likely to be positive reactors (OR = 3.2, 95% CI: 2.2–4.7). Landim local breed showed a lower prevalence than crossbred animals (Landim × Brahman) (OR = 0.6, 95% CI: 0.4–0.8).Conclusions/SignificanceThe findings reveal an urgent need for intervention with effective, area-based, control measures in order to reduce bTB prevalence and prevent its spread to the human population. In addition to the high prevalence, population habits in Govuro, particularly the consumption of raw milk, clearly may potentiate the transmission to humans. Thus, further studies on human tuberculosis and the molecular characterization of the predominant strain lineages that cause bTB in cattle and humans are urgently required to evaluate the impact on human health in the region.

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“…In 2007, Turkish scientists described the vertical transmission of M. bovis from an infected dam to her calf through congenital infection in utero [90]. Ingestion of contaminated colostrum/milk is another way of bTB transmission from cow to calf, as suggested by Italian scientists in 1998 [125].…”

Section: Risk Factors At the Animal Levelmentioning

confidence: 99%

Classification of worldwide bovine tuberculosis risk factors in cattle: a stratified approach

2009

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The worldwide status of bovine tuberculosis (bTB) as a zoonosis remains of great concern. This article reviews the main risk factors for bTB in cattle based on a three-level classification: animal, herd and region/country level. A distinction is also made, whenever possible, between situations in developed and developing countries as the difference of context might have consequences in terms of risk of bTB. Recommendations are suggested to animal health professionals and scientists directly involved in the control and prevention of bTB in cattle. The determination of Millenium Development Goals for bTB is proposed to improve the control/eradication of the disease worldwide.

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Suspected congenital generalised tuberculosis in a newborn calf

Cited by 16 publications

References 0 publications

Pathology of Camel Tuberculosis and Molecular Characterization of Its Causative Agents in Pastoral Regions of Ethiopia

Pathology of Camel Tuberculosis and Molecular Characterization of Its Causative Agents in Pastoral Regions of Ethiopia

Prevalence of Bovine Tuberculosis and Risk Factor Assessment in Cattle in Rural Livestock Areas of Govuro District in the Southeast of Mozambique

Classification of worldwide bovine tuberculosis risk factors in cattle: a stratified approach

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