Suspected anaphylactoid reaction following intravenous administration of a gadolinium–based contrast agent in three dogs undergoing magnetic resonance imaging

Girard, Nicolas; Leece, Elizabeth A

doi:10.1111/j.1467-2995.2010.00545.x

Cited by 39 publications

(67 citation statements)

References 19 publications

(22 reference statements)

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“…Several reasons account for this low publication rate, including under-reporting of anaphylaxis due to failure of recognition, difficulty in confirming a suspected causative agent and publication bias (preference for novelty and a positive outcome, and a reduction in the publication of single case reports). Reports in the veterinary literature have implicated antibiotics, vaccines, opioids, NSAIDs, intravenous anaesthetic induction agents, radiocontrast media and non-medicinal causes (BAER et al 1962, Carter et al 2011, Clutton 1987, Davis 1984, Girard and Leece 2010, Harðardottir et al 2015, Kushner and Trim 1994, Mason 1976, Okushima et al 2013, Pollard and Pascoe 2008, Rossanese and Rigotti 2015.…”

Section: Discussionmentioning

confidence: 99%

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Suspected anaphylaxis from intravenous cefazolin during general anaesthesia in a dog

Prebble¹,

Pang

2016

Preprint

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A 6-year-old female Shetland Sheepdog with a history of cardiorespiratory compromise during general anaesthesia was referred for ovariohysterectomy surgery. Clinical examination was unremarkable at presentation and physiologic parameters under general anaesthesia were within expected ranges during preparation for surgery. Shortly after completion of an intravenous injection of cefazolin, the audible signal from the Doppler ultrasound unit stopped. A rapid survey of the patient revealed tachycardia with weak femoral pulses, tachypnoea, hyperpnoea and substantially increased resistance to manual positive pressure ventilation. Stopping inhalant anaesthesia, administering salbutamol, corticosteroids and diphenhydramine were associated with resolution of clinical signs. However, marked hypotension and resistance to ventilation recurred approximately 25 minutes later. Low dose intravenous epinephrine (5 mcg/kg) was effective at increasing arterial blood pressure and reversing respiratory dysfunction. Surgery was completed and the patient recovered uneventfully. Initial reliance on second line therapy and delay in administering epinephrine, the recommended treatment for anaphylaxis, may have slowed resolution of clinical signs.

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Section: Discussionmentioning

confidence: 99%

“…Suspected triggers include antibiotics, opioids, radiocontrast media, non-steroidal antiinflammatory drugs (NSAIDs) and intravenous anaesthetics (Clutton 1987, Davis 1984, Girard and Leece 2010, Kushner and Trim 1994, Mason 1976, Okushima et al 2013, Pollard and Pascoe 2008, Rossanese and Rigotti 2015.…”

Section: Introductionmentioning

confidence: 99%

Suspected anaphylaxis from intravenous cefazolin during general anaesthesia in a dog

Prebble¹,

Pang

2016

Preprint

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“…Hence, the immune system was not sensitised to a hapten and an anaphylactic non-IgE-mediated reaction was suspected (Lorenz and others 1978, Armitage-Chan 2010, Girard and Leece 2010). …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, periocular and labial oedema were also noted. The dyspnoea was most likely associated with obstruction of the upper airway due to lingual, laryngeal and pharyngeal oedema, whereas the cardiovascular changes may be due to hypotension associated with vasodilation and fluid extravasation (Brown 2005, Girard and Leece 2010, Shmuel and Cortes 2013). …”

Section: Discussionmentioning

confidence: 99%

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Suspect anaphylaxis following intravenous buprenorphine administration in a dog

Rossanese

Rigotti

2015

Vet Record Case Reports

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A seven‐month‐old French Mastiff was scheduled to undergo exploratory laparotomy for the removal of gastric foreign bodies. Buprenorphine 20 μg/kg was administered intravenously as preanaesthetic medication. Five minutes after the injection, tachypnoea, dyspnoea, cyanosis and tachycardia developed; periorbital, labial and lingual oedema were also noted. Anaesthesia was induced with 4 mg/kg of propofol, and laryngeal visualisation revealed severe laryngeal oedema. The trachea was intubated with a 6 mm endotracheal tube and anaesthesia was maintained with isoflurane in oxygen. Fluid therapy was started and glucocorticoids were administered. The exploratory laparotomy was completed and gastric foreign bodies were removed. A temporary tracheostomy was performed as no improvement of the laryngeal oedema was detected. The patient recovered uneventfully and after 48 hours the tracheostomy tube was removed successfully. The reaction may be attributed to histamine release following injection of buprenorphine.

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Hypersensitivity and Anaphylaxis

Hoehne

Hopper

2018

Textbook of Small Animal Emergency Medicine

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Suspected anaphylactoid reaction following intravenous administration of a gadolinium–based contrast agent in three dogs undergoing magnetic resonance imaging

Cited by 39 publications

References 19 publications

Suspected anaphylaxis from intravenous cefazolin during general anaesthesia in a dog

Suspected anaphylaxis from intravenous cefazolin during general anaesthesia in a dog

Suspect anaphylaxis following intravenous buprenorphine administration in a dog

Hypersensitivity and Anaphylaxis

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