Suspected adverse events, 2012

Davis, Giles; Rooney, A; Cooles, S.; Evans, Gary W.

doi:10.1136/vr.f7381

Cited by 8 publications

(4 citation statements)

References 1 publication

(1 reference statement)

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“…This distribution of adverse events by animal species is similar to that obtained by Naidoo and Sykes [26] in South Africa, Coulibaly [22] in Ivory Coast, Assoumy et al [10] in Senegal and Davis et al [27] in Britain who showed that dogs were the main species affected by ADRs after administration of veterinary drugs at proportions of 60, 51, 39 and 41%, respectively. Also, intense clinical activities are oriented towards canine medicine in these countries resulting in a high incidence of adverse drug effects in these species.…”

Section: Discussionsupporting

confidence: 86%

Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon

et al. 2019

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Background Sub-Saharan African market is highly affected by counterfeit veterinary drugs. Though these counterfeit and non-compliance of drugs can induce adverse effects during their utilization, there is no monitoring system of veterinary medicines. The present pilot study was carried out in Cameroon to identify and describe suspected cases of adverse reactions to veterinary drugs in animals and / or humans as well as inefficacy of veterinary drugs. The methodology involved a descriptive cross-sectional survey of 67 actors in the veterinary medicine sector in Cameroon. Results A total of 74/120 (62%) cases of suspected adverse effects and or lack of efficacy of veterinary drugs in animals and 46 (38%) cases of adverse reactions in humans were identified. Antiparasitics were the most incriminated therapeutic class in animals (61%) and human (56%). Adverse reactions were reported in dogs (44%) and poultry (24%) while drug inefficacy was most observed in poultry (47%). According to animal health professionals, levamisole (24%) and ivermectin (16%) were identified to be responsible for the adverse effects and that the highest level of inefficacy was most frequently reported for oxytetracycline (29%). The main adverse reactions were systemic (22%), gastrointestinal (20%) and neurological (13%) disorders. Conclusion The results of this study showed that misuse and circulation of poor quality as well as lack of efficacy of veterinary drugs is very common in Cameroon. Adverse reactions were observed in animals and humans. Therefore, the establishment of a national veterinary pharmacovigilance system based on solid legal bases is essential for a continuous assessment of the risks-benefits effects of veterinary drugs marketed in Cameroon. Electronic supplementary material The online version of this article (10.1186/s12917-019-2043-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 86%

Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon

et al. 2019

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“…However, these findings also indicate that no vaccines were risk-free and that other factors also can be associated with the development of FISS [ 59 ]. The latter finding is also supported by the data from the UK VMD receiving notifications of FISSs in cats vaccinated with MLV, inactivated, and recombinant vaccines [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Feline Injection-site Sarcoma (Fiss)supporting

confidence: 56%

“…Many causes of inflammation could be associated with FISS development, and FISSs can occur in animals following vaccination with inactivated, recombinant, modified live vaccines as well as with non-vaccine injections, e.g., in the UK, the VMD received notifications of FISSs in cats associated with different vaccines. However, these reports did not take the number of injected vaccines into account [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. In a prospective case-control study conducted at the University of California, Davis, USA, it was demonstrated that, among injections, vaccines were more frequently associated with FISS development compared to other compounds; amongst vaccines, the risk was significantly higher when adjuvanted vaccines were used [ 59 ].…”

Section: Feline Injection-site Sarcoma (Fiss)mentioning

confidence: 99%

“…With one exception, namely the development of feline injection-site sarcomas (FISSs) (subcutaneous sarcomas at an injection site), the number of published studies on VAAEs in cats is limited. In the UK, surveillance work carried out by the Veterinary Medicines Directorate (VMD), including pharmacovigilance reports on VAAEs after drug use in animals, are published regularly [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], and the pharmacovigilance reporting system in the UK continues to provide an excellent example of practical and effective arrangements for collecting this important information [ 10 ]. However, such reporting systems on adverse effects, including VAAEs, do not provide proof of a causal relationship between drug application (e.g., vaccination) and adverse events (e.g., VAAEs), although the association of vaccination with the development of disease is often observed if a close temporal relationship exists with the administration of the vaccine(s) [ 4 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats

Hartmann¹,

Egberink

Möstl

et al. 2023

Viruses

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Vaccine-associated adverse events (VAAEs), including feline injection-site sarcomas (FISSs), occur only rarely but can be severe. Understanding potential VAAEs is an important part of informed owner consent for vaccination. In this review, the European Advisory Board on Cat Diseases (ABCD), a scientifically independent board of feline medicine experts, presents the current knowledge on VAAEs in cats, summarizing the literature and filling the gaps where scientific studies are missing with expert opinion to assist veterinarians in adopting the best vaccination practice. VAAEs are caused by an aberrant innate or adaptive immune reaction, excessive local reactions at the inoculation site, an error in administration, or failure in the manufacturing process. FISS, the most severe VAAE, can develop after vaccinations or injection of other substances. Although the most widely accepted hypothesis is that chronic inflammation triggers malignant transformation, the pathogenesis of FISS is not yet fully understood. No injectable vaccine is risk-free, and therefore, vaccination should be performed as often as necessary, but as infrequently as possible. Vaccines should be brought to room temperature prior to administration and injected at sites in which FISS surgery would likely be curative; the interscapular region should be avoided. Post-vaccinal monitoring is essential.

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Immunization

Sykes¹

2021

Greene's Infectious Diseases of the Dog and Cat

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Suspected adverse events, 2012

Cited by 8 publications

References 1 publication

Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon

Veterinary pharmacovigilance in sub-Sahara Africa context: a pilot study of adverse reactions to veterinary medicine in Cameroon

Feline Injection-Site Sarcoma and Other Adverse Reactions to Vaccination in Cats

Immunization

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