Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Demarco, Ana Lúcia G.; Rodrigues, Maria de Lourdes Veronese; Figueiredo, J F C; Deghaide, Neifi Hassan Saloum; Menezes, Marcelo Bezerra de; Demarco, Luís A.; Fernandes, Ana Paula; Donadi, Eduardo Antônio

doi:10.1155/2012/612030

Cited by 8 publications

(5 citation statements)

References 20 publications

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“…Besides HLA-G , other genes of the Major Histocompatibility Complex have been previously associated with CMV-R, including: (1) the overrepresentation of TNF microsatellites ( TNFc2 alleles, as well as the 4-1-G-2-2-1 haplotype, which contains the TNFc2 allele) in patients with AIDS, inducing a rapid progression of the disease as well as the development of accelerated CMV-R 27 , (2) the HLA-A31 antigen was associated with the development of AIDS, irrespective of the presence or not of CMV-R 17 , (3) the HLA-C*07 allele group was assoaciated with protection against the development of CMV-R when compared to patients with AIDS without CMV-R. In addition, the HLA-C *05 allele group was associated with susceptibility to and the HLA-C*16 allele group with protection against AIDS development, irrespective of the presence or not of CMV-R 19 , and (4) the HLA-B35 antigen was associated with the rapid progression of AIDS and development of retinochoroidites induced by Toxoplasma gondii 18 .…”

Section: Discussionmentioning

confidence: 98%

Variability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis

Vicente

Castelli

Rodrigues

et al. 2020

Sci Rep

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Cytomegalovirus retinochoroiditis (CMV-R) is the primary cause of blindness among AIDS patients. Since HLA-G is associated with the modulation of the immune response, we hypothesized that variability at the 3′ untraslated region (3′UTR) of the gene could be implicated on the predisposition to CMV-R. We evaluated whether HLA-G 3′UTR influences CMV-R development in Brazilian AIDS patients. Peripheral blood DNA was obtained from two groups of patients: (1) AIDS exhibiting CMV-R (n = 40) and (2) AIDS without CMV-R (n = 147). HLA-G 3′UTR typing was performed using sequencing analysis. Allele, genotype and haplotype frequencies were evaluated using Fisher’s exact test accompanied by the calculation of the odds ratio and its 95% confidence interval (95% CI). The etiologic (EF) and preventive fractions were also estimated. Compared to AIDS patients without CMV-R, AIDS patients with CMV-R showed increased frequencies of the: (1) + 3001T allele, (2) the + 3001C/T genotype and (3) the UTR-17 (InsTTCCGTGACG) haplotype (EFs = 0.02–0.04). The UTR-3 (DelTCCGCGACG) haplotype was associated with protection against CMV-R development. Although the risk for developing CMR-V at the population level was relatively low (EF), the identification of HLA-G 3′UTR variation sites may help to further evaluate the role of post-transcriptional factors that may contribute to the existent immunosuppresion caused by HIV per se.

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Section: Discussionmentioning

confidence: 98%

Variability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis

Vicente

Castelli

Rodrigues

et al. 2020

Sci Rep

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“…It is known that the HLA-B35 antigen is one of the genes associated with the severity of AIDS and with the presence of T.gondii and CMV retinochoroiditis [10][11][12][13][14] , and that a CD 4 + lymphocyte count of less than 50 cells/mm 3 is the main factor predisposing to the development of CMV-R, with the risk of these patients being 32.2 times higher than the risk of patients with CD4 + lymphocyte counts of 51-100/mm 3 14,15 .…”

Section: Discussionmentioning

confidence: 99%

Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement

Souza

Deghaide³

et al. 2015

cbr

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Introduction: Cytomegalovirus retinitis is one of the ocular manifestations of AIDS. The objective of the present study was to determine possible associations of class I and II HLA antigens and alleles in patients with AIDS and cytomegalovirus retinitis (CMV-R) with and without macular involvement. Method: The study population consisted of 22 patients with AIDS and CMV-R with macular involvement (Group I), 19 patients with AIDS and CMV-R without macular involvement (Group II), and 202 individuals with negative serology for human immunodeficiency virus (Group III-control). Class I HLA antigens were typed by classical serology. Class II alleles were identified using sequence-specific oligonucleotide primers hybridized with amplified DNA. Results: HLA-DRB1*14 and HLA-DRB1*10 specificities were more frequent among patients with macular involvement, possibly indicating greater susceptibility to this condition. In contrast, the HLA-B35 antigen may be associated with protection against macular involvement since it was significantly more frequent among patients without this involvement. Conclusions: The HLA-DRB1*14 and HLA-DRB1*10 alleles may favor the development of CMV-R with macular involvement, whereas the HLA-B35 subtype may be associated with protection against macular involvement.

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“…The Human Leukocyte Antigen (HLA) is highly polymorphic and plays an essential role in the immune response. A recent study showed that HLA-B35 is a Class I HLA marker that predisposes to OT [52].…”

Section: Immune Response During Retinal Infectionmentioning

confidence: 99%

Ocular Toxoplasmosis: Mechanisms of Retinal Infection and Experimental Models

2021

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Ocular toxoplasmosis (OT) is caused by the parasite Toxoplasma gondii and affects many individuals throughout the world. Infection may occur through congenital or acquired routes. The parasites enter the blood circulation and reach both the retina and the retinal pigment epithelium, where they may cause cell damage and cell death. Different routes of access are used by T. gondii to reach the retina through the retinal endothelium: by transmission inside leukocytes, as free parasites through a paracellular route, or after endothelial cell infection. A main feature of OT is the induction of an important inflammatory state, and the course of infection has been shown to be influenced by the host immunogenetics. On the other hand, there is evidence that the T. gondii phenotype also has an impact on the distribution of the pathology in different areas. Although considerable knowledge has been acquired on OT, a deeper knowledge of its mechanisms is necessary to provide new, more targeted treatment strategies. In particular, in addition to in vitro and in vivo experimental models, organotypic, ex vivo retinal explants may be useful in this direction.

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Susceptibility to Toxoplasmic Retinochoroiditis Is Associated with Hla Alleles Reported to Be Implicated with Rapid Progression to Aids

Cited by 8 publications

References 20 publications

Variability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis

Variability at the 3′ untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis

Human leucocyte antigen profile in patients with aids and cytomegalovirus retinitis with and without macular involvement

Ocular Toxoplasmosis: Mechanisms of Retinal Infection and Experimental Models

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