Susceptibility to Tinnitus Revealed at 2 kHz Range by Bilateral Lower DPOAEs in Normal Hearing Subjects with Noise Exposure

Job, Agnès; Raynal, M.; Kossowski, M.

doi:10.1159/000099025

Cited by 42 publications

(37 citation statements)

References 33 publications

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“…This phenomenon has been indirectly reported in the vast majority tinnitus related publications but has not been studied systematically. For example, most clinical cases reported a strong correlation between hearing loss and tinnitus (Weisz et al, 2006), whereas other studies described tinnitus cases where tinnitus patients demonstrated no audiometric deficits (Schmuziger et al, 2006; Job et al, 2007; Langers et al, 2012). The diversity of tinnitus pathologies seen in the current study and other animal studies (Longenecker and Galazyuk, 2011; Coomber et al, 2014; Hickox and Liberman, 2014; Ropp et al, 2014) could be explained by a number of phenotypic factors including differences in individual animals in stress levels, unintentional noise exposure, differential peripheral damage, or unique animal-specific maladaptive neuroplasticity pattern caused by sound exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Following this damage, the central auditory system increases its gain to compensate for the reduced sensorineural input from the cochlea, which can lead to tinnitus (Salvi et al, 2000; Schaette and McAlpine, 2011; Auerbach et al, 2014). In most clinical cases, there is a strong correlation between hearing loss and tinnitus (Lockwood et al, 2002), but interestingly, this is not always true, as some patients with clinically normal thresholds have tinnitus (Weisz et al, 2006; Job et al, 2007). Just as in humans (Hall et al, 2016), the extent of peripheral damage and central plasticity in individual animals of the AOE model differs greatly, leading to a heterogeneous population of hearing loss (HL) and/or tinnitus pathology (Longenecker and Galazyuk, 2011; Singer et al, 2013; Hickox and Liberman, 2014; Knipper et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Longenecker

Galazyuk

2016

Front. Behav. Neurosci.

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The etiology of tinnitus is known to be diverse in the human population. An appropriate animal model of tinnitus should incorporate this pathological diversity. Previous studies evaluating the effect of acoustic over exposure (AOE) have found that animals typically display increased spontaneous firing rates and bursting activity of auditory neurons, which often has been linked to behavioral evidence of tinnitus. However, only a subset of studies directly associated these neural correlates to individual animals. Furthermore, the vast majority of tinnitus studies were conducted on anesthetized animals. The goal of this study was to test for a possible relationship between tinnitus, hearing loss, hyperactivity and bursting activity in the auditory system of individual unanesthetized animals following AOE. Sixteen mice were unilaterally exposed to 116 dB SPL narrowband noise (centered at 12.5 kHz) for 1 h under ketamine/xylazine anesthesia. Gap-induced prepulse inhibition of the acoustic startle reflex (GPIAS) was used to assess behavioral evidence of tinnitus whereas hearing performance was evaluated by measurements of auditory brainstem response (ABR) thresholds and prepulse inhibition PPI audiometry. Following behavioral assessments, single neuron firing activity was recorded from the inferior colliculus (IC) of four awake animals and compared to recordings from four unexposed controls. We found that AOE increased spontaneous activity in all mice tested, independently of tinnitus behavior or severity of threshold shifts. Bursting activity did not increase in two animals identified as tinnitus positive (T+), but did so in a tinnitus negative (T−) animal with severe hearing loss (SHL). Hyperactivity does not appear to be a reliable biomarker of tinnitus. Our data suggest that multidisciplinary assessments on individual animals following AOE could offer a powerful experimental tool to investigate mechanisms of tinnitus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Longenecker

Galazyuk

2016

Front. Behav. Neurosci.

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“…4 ). Despite the fact that a relationship between otoacoustic emissions and tinnitus has yet to be established, altered otoacoustic emissions in individuals with tinnitus and normal hearing have been described in the literature [Shiomi et al, 1997;Onishi et al, 2004;Gouveris et al, 2005;Ozimek et al, 2006;Job et al, 2007;Ami et al, 2008]. Ami et al [2008] stated that subtle damage to the outer hair cells can provoke tinnitus before the impairment alters the audiogram.…”

Section: Discussionmentioning

confidence: 99%

“…Impairment in cochlear function was demonstrated even in individuals with tinnitus and normal hearing [Shiomi et al, 1997;Onishi et al, 2004;Gouveris et al, 2005;Ozimek et al, 2006;Job et al, 2007;Ami et al, 2008]. Weisz et al [2006] demonstrated that patients with tinnitus and normal hearing do not necessarily present peripheral auditory integrity, which underscores the importance of investigating cochlear function in patients presenting such characteristics.…”

Section: Introductionmentioning

confidence: 99%

Influence of Cochlear Function on Auditory Temporal Resolution in Tinnitus Patients

Sanches

Sánchez

Carvallo³

2010

Audiol Neurotol

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Our aim was to analyze the influence of subtle cochlear damage on temporal auditory resolution in tinnitus patients. Forty-eight subjects (hearing threshold ≤25 dB HL) were assigned to one of two experimental groups: 28 without auditory complaints (mean age, 28.8 years) and 20 with tinnitus (mean age, 33.5 years). We analyzed distortion product otoacoustic emission growth functions (by threshold, slope, and estimated amplitude), extended high-frequency thresholds, and the Gaps-in-Noise test. There were differences between the groups, principally in the extended high-frequency thresholds and the Gaps-in-Noise test results. Our findings suggest that subtle peripheral hearing impairment affects temporal resolution in tinnitus, even when pure-tone thresholds as conventionally measured appear normal.

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“…Of the 12 international papers in the Medline database, 6 used DPOAE24 25 19 20 27 30 and 6 used both tests18 28 21 12 29 17 13 26.…”

Section: Resultsmentioning

confidence: 99%

Evoked otoacoustic emissions in workers exposed to noise: A review

Alcarás¹,

Lüders²,

França³

et al. 2012

Int Arch Otorhinolaryngol

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Summary Introduction: The otoacoustic emissions test is an essential tool in the evaluation of auditory function, since it allows the early detection of cochlear damage of occupational origin. Objective: To present a review of the literature and analyze the effectiveness of the clinical application of the otoacoustic emissions test in workers exposed to noise. Methods: A bibliographical search covering a period of 10 years was performed in the Virtual Health Library including published articles in national and international journals indexed in the internationally recognized databases for the health sciences, LILACS, SCIELO, and MEDLINE, using the terms “otoacoustic emissions” and “occupational exposure.” The type of published article (national/international), the type and intensity of the stimulus most commonly used for the evoked otoacoustic emissions, the gender and age of the subjects, and the conclusions from the retrospective studies were all taken into consideration. Results and Conclusions: A total of 19 articles were analyzed, 7 national and 12 international, covering subjects from 17 to 77 years of age, mostly men. The type of stimulus most commonly used for the evoked otoacoustic emissions was the distortion method (12). Through this review, we have concluded that testing of evoked otoacoustic emissions in workers exposed to noise is an important tool in the early diagnosis of noise-induced cochlear hearing disorders.

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Susceptibility to Tinnitus Revealed at 2 kHz Range by Bilateral Lower DPOAEs in Normal Hearing Subjects with Noise Exposure

Cited by 42 publications

References 33 publications

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

Influence of Cochlear Function on Auditory Temporal Resolution in Tinnitus Patients

Evoked otoacoustic emissions in workers exposed to noise: A review

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