“…Following this damage, the central auditory system increases its gain to compensate for the reduced sensorineural input from the cochlea, which can lead to tinnitus (Salvi et al, 2000; Schaette and McAlpine, 2011; Auerbach et al, 2014). In most clinical cases, there is a strong correlation between hearing loss and tinnitus (Lockwood et al, 2002), but interestingly, this is not always true, as some patients with clinically normal thresholds have tinnitus (Weisz et al, 2006; Job et al, 2007). Just as in humans (Hall et al, 2016), the extent of peripheral damage and central plasticity in individual animals of the AOE model differs greatly, leading to a heterogeneous population of hearing loss (HL) and/or tinnitus pathology (Longenecker and Galazyuk, 2011; Singer et al, 2013; Hickox and Liberman, 2014; Knipper et al, 2015).…”