Susceptibility to stress in young rats after 2-week zinc deprivation

Watanabe, Mamoru; Tamano, Haruna; Kikuchi, Toshinori; Takeda, Atsüshi

doi:10.1016/j.neuint.2009.11.014

Cited by 55 publications

(49 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extracellular glutamate accumulation in the hippocampus is potentiated by glucocorticoids [59], the main hormones of the hypothalamic-pituitary-adrenal (HPA) axis. It is thought that zinc deficiency can cause alterations of the HPA axis in depression [30,60,66,68]. During zinc deficiency, chronic alteration of corticosterone secretion and a decrease in synaptic zinc levels seems to be linked to the excitability of glutamatergic neurons in the hippocampus [58,60].…”

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

“…The increase in basal Ca 2+ levels was observed in zinc deficiency [62]. Study of Watanabe et al [68] showed an increased serum glucocorticoid concentration in zinc deficiency, which may facilitate glutamate release and inhibit glutamate removal by glutamate transporters [68]. The enhanced exocytosis in zinc deficiency is a possible mechanism on abnormal increase in extracellular glutamate [58].…”

Section: Introductionmentioning

confidence: 98%

“…Approximately 50% of the world's population is at risk of zinc deficiency [3]. There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms [5,29,64,68,69]. Zinc shows antidepressant-like properties in preclinical test and models [6,10,20,21,36,42,52].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported recently that zinc deficiency induced by a zinc-deficient diet evokes behavioral disturbances in animals, e.g., enhanced depression-like behavior was found after dietary zinc deprivation in the tail suspension test (TST) [31,69] and the forced swim test (FST) [30,63,64,68,69] and was reversed by desipramine [69] while administration of fluoxetine did not reduce behavioral despair caused by zinc deprivation [64]. Some authors correlate zinc deficient-induced depression-like behavior with hyperactivation of the hypothalamicpituitary-adrenal (HPA) axis [30,60,68]. This may in turn be linked to the dyshomeostasis of glutamatergic system.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

View full text Add to dashboard Cite

Abstract:Background: There is some evidence coming from preclinical and clinical studies suggesting a relationship between dietary zinc intake and depressive symptoms. The aim of the study was to determine whether zinc deficiency alters the response to antidepressants with a different mechanism of action. We examine also whether these changes are related to activity of the hypothalamic-pituitaryadrenal HPA axis. Methods: Male CD-1 mice were assigned to groups according to diet and antidepressant administration. To evaluate animal behavior, the immobility time in the forced swim test (FST) and locomotor activity were measured. To determine serum zinc levels the flame atomic absorption spectroscopy (FAAS) was used. The serum corticosterone was determined by radioimmunoassay (RIA). Results: Antidepressants administered to zinc-deprived mice induced an altered response in the FST when compared to animals fed with an adequate diet. There were no changes in locomotor activity. Animals subjected to a zinc-deficient diet showed a significant reduction in serum zinc levels, which was normalized by antidepressant treatment. An increase in serum corticosterone concentrations in mice fed with a zinc-deficient diet and treated with antidepressants was observed, so it can be concluded that reduced levels of zinc contribute hyperactivation of the HPA axis. Conclusion:The results of this study suggest that a diet with a reduced zinc level alters antidepressant action, which is associated with a reduction in the serum zinc level and rise in the corticosterone level. The results of this study may indicate the involvement of zinc deficiency in the pathogenesis of depression.

show abstract

Section: Zinc Deficiency Alters Responsiveness To Antidepressantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Młyniec

Budziszewska

Reczyński

et al. 2013

Pharmacological Reports

View full text Add to dashboard Cite

show abstract

“…Zinc-containing neurons are receptive to glutamine, an amino acid neurotransmitter that is excitatory and that exerts a neuromodulatory effect on post-synaptic glutamate receptors within the hypothalamic-pituitary-adrenal axis (HPA) system (4,5) . Rodent studies have indicated that this action occurs mainly through the hippocampus synapses, which are involved in the regulation of the HPA system (6)(7)(8)(9)(10)(11) . Zinc may also be involved in the control of the serotonergic system (5,12,13) .…”

mentioning

confidence: 99%

Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Stewart-Knox

Rae

Simpson

et al. 2011

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans. Subjects: Healthy volunteers (n 387) aged 55-87 years were recruited. Setting: Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70-87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55-70 years. Design: Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention. Results: Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55-70 years or the $70 years age group. Conclusions: These results suggest that zinc does not benefit mood in healthy older people.

show abstract

Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances

Takeda

Tamano

2010

J of Neuroscience Research

Self Cite

View full text Add to dashboard Cite

Humans and animals are constantly exposed to environmental stress. The hypothalamic-pituitary-adrenal (HPA) axis responds to stress, followed by glucocorticoid secretion from the adrenal glands. This response serves to maintain homeostasis in the living body through energy mobilization or to restore it. The brain is an important target for glucocorticoids. The hippocampus participates in the regulation of the HPA axis. Stress activates glutamatergic neurons in the hippocampus, and serious stress induces dyshomeostasis of extracellular glutamate. This dyshomeostasis, which is potentiated by glucocorticoids, modifies cognitive and emotional behavior. On the other hand, zinc is necessary for glucocorticoid signaling and is released from glutamatergic (zincergic) neurons to modulate synaptic glutamate signaling. Stress also induces dyshomeostasis of extracellular zinc, which may be linked to dyshomeostasis of extracellular glutamate. Thus, glucocorticoid signaling might also contribute to dyshomeostasis of extracellular zinc. It is likely that zinc signaling participates in cognitive and emotional behavior through glucocorticoid and glutamate signaling under stressful circumstances. This Mini-Review analyzes the relationship among signals of glucocorticoid, glutamate, and zinc under stressful circumstances to elucidate the significance of the zinc signaling in response to stress.

show abstract

Susceptibility to stress in young rats after 2-week zinc deprivation

Cited by 55 publications

References 51 publications

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Zinc deficiency alters responsiveness to antidepressant drugs in mice

Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances

Contact Info

Product

Resources

About