Susceptibility to secondary bacterial infections in growing pigs as an early response in ochratoxicosis

Stoev, Stoycho D.; Goundasheva, D.; Mirtcheva, Teodora; Mantle, Peter G.

doi:10.1016/s0940-2993(00)80049-4

Cited by 74 publications

(51 citation statements)

References 13 publications

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“…The extent to which OTA may interact with other components of commercial chicken rations compounded from agricultural produce may also influence the significance of the relatively lower doses of OTA that commercial chickens may encounter in some feed. Moreover, OTA induced nephropathies in pigs or chickens have been previously related to an increased sensibility to bacterial infections [8,30], which could additionally complicate the clinicomorphological picture of these nephropathies.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

et al. 2002

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-Histopathological, biochemical and toxicological investigations of tissues and blood of normally slaughtered chickens exhibiting different frequencies (1-2%, 40-50% and above 80%) of nephropathy changes (congested or pale and enlarged kidneys) at the slaughtering meat inspection were carried out to elucidate the aetiology of nephropathies of chickens encountered in Bulgaria. A close relationship was observed between the frequency of this nephropathy and the rate of nephrotoxic mycotoxin ochratoxin A in muscles, kidneys and livers of chickens, but the levels of ochratoxin A in corresponding feed samples (0.1-0.3 ppm) were significantly lower than the levels (2-4 ppm) required to reproduce such nephropathy. Clinicomorphological changes such as nervous symptoms, vascular and oedematous changes in various internal organs and the brain, and subcutaneous or liver and kidney haemorrhages in addition to known degenerative changes in the kidneys, liver and lymphoid organs differed from the classical description of the nephropathy made in Scandinavia. The conclusion is that the Bulgarian chicken nephropathy may have a multitoxic aetiology because it cannot be explained by the concentration of ochratoxin A alone. mycotoxic nephropathy / ochratoxicosis / mycotoxin / ochratoxin A / pathology Résumé -Néphropathie mycotoxique spontanée sans étiologie mycotoxique déterminée chez des poulets bulgares. Des études histopathologiques, biochimiques et toxicologiques des tissus et du sang de poulets montrant des fréquences variées (1-2 %, 40-50 % et supérieures à 80 %) de changements néphropathiques (reins congestionnés ou pâles et hypertrophiés) lors de l'inspection des viandes à l'abattoir, ont été entreprises afin de déterminer l'étiologie des néphropathies du poulet en Bulgarie. Une relation étroite a été observée entre la fréquence de cette néphropathie et le taux de la

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Section: Discussionmentioning

confidence: 99%

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

et al. 2002

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“…Some studies clearly confirmed that immunosuppression may be the first expressed toxic effect of some mycotoxins, such as ochratoxin A (Stoev et al, 2000). It was also found that FB 1 given at diet levels of 10 ppm, has immunosuppressive effect on humoral immune response in pigs (Stoev et al, 2012) and therefore can provoke some secondary bacterial infections, which arise in immunocompromised animals.…”

Section: Introductionmentioning

confidence: 89%

“…The most mycotoxins have strong immunosuppressive effects and often compromise animals and human health provoking development of secondary bacterial infections (Stoev et al, 2000) or deteriorating some existing diseases (Pósa et al, 2011(Pósa et al, , 2013. It is well known, that Fumonisin B 1 (FB 1 ) is one of the most frequent contaminant of the feeds for pigs in all over the world (Dutton, 2009).…”

Section: Introductionmentioning

confidence: 99%

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Kovács

Pósa

Tuboly

et al. 2016

Research in Veterinary Science

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The possible interaction between Pasteurella multocida and the mycotoxin fumonisin B1 (FB1), recognised as one of the most often food/feed contaminant, was studied with the aim to evaluate whether and how FB1 can influence and/or complicate the development and severity of various pathological damages provoked by Pasteurella multocida in some internal organs of pigs. Heavier lung pathology was seen in pigs experimentally infected with Pasteurella multocida, when the same were exposed to 20 ppm dietary levels of fumonisin B 1 (FB 1 ) as was assessed by gross pathology, pathomorphological examinations, clinical biochemistry and some immunological investigations. The most typical damages in FB 1 treated pigs were the strong oedema in the lung and the slight oedema in the other internal organs and mild degenerative changes in the kidneys, whereas the typical pathomorphological findings in pigs infected with Pasteurella multocida was broncho-interstitial pneumonia. FB1 was found to aggravate pneumonic changes provoked by P. multocida in the cranial lobes of the lung and to complicate pneumonic damages with interstitial oedema in the lung. No macroscopic damages were observed in the pigs infected only with Pasteurella multocida. It can be concluded that the feed intake of FB1 in pigs may complicate or exacerbate the course of P. multocida serotype A infection.

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“…Several studies describe an increased susceptibility to experimental or natural mucosal infections after the ingestion of some mycotoxins [18,32,33]. Hara-Kudo et al [21] examined the effects of DON on Salmonella Enteritidis infection in mice and suggested that administration of 2 mg/L DON in the drinking water reduced resistance to peroral infection of Salmonella Enteritidis presumably by inhibiting the cell-mediated immune function.…”

Section: Introductionmentioning

confidence: 99%

The mycotoxin deoxynivalenol promotes uptake ofSalmonellaTyphimurium in porcine macrophages, associated with ERK1/2 induced cytoskeleton reorganization

Vandenbroucke¹,

Croubels²,

Verbrugghe³

et al. 2009

Vet. Res.

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-Both the mycotoxin deoxynivalenol (DON) and Salmonella Typhimurium are major issues in swine production. This study aimed at examining the interaction between DON and Salmonella Typhimurium at the level of the porcine innate immune system, represented by macrophages. First, we assessed the direct cytotoxic effect of DON on porcine macrophages. Incubation with 0.25 lg/mL of DON or higher resulted in a significant cytotoxic effect after 24 h of incubation. Secondly, the direct toxic effect of DON on the growth and on the expression of Salmonella pathogenicity island 1 (SPI-1) and SPI-2 virulence genes of Salmonella Typhimurium was determined. At low non-cytotoxic concentrations, as can be found in the serum of pigs, DON did not have any effect on either growth or virulence gene expression of Salmonella Typhimurium. However, when the invasion and intracellular survival of Salmonella Typhimurium in macrophages preexposed to 0.025 lg/mL of DON was examined, DON significantly promoted the uptake of Salmonella Typhimurium into macrophages. The enhanced uptake coincided with marked F-actin reorganization of the cells, which was due to the activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2). These results suggest that low but relevant concentrations of DON modulate the innate immune system and could thus increase the susceptibility of pigs to infections with Salmonella Typhimurium.deoxynivalenol / Salmonella Typhimurium / pig / macrophage / cytoskeleton

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Susceptibility to secondary bacterial infections in growing pigs as an early response in ochratoxicosis

Cited by 74 publications

References 13 publications

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

The mycotoxin deoxynivalenol promotes uptake ofSalmonellaTyphimurium in porcine macrophages, associated with ERK1/2 induced cytoskeleton reorganization

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