Susceptibility to Plasmodium berghei: Parasitological, Biochemical and Hematological Studies in Laboratory and Wild Mammals

Bt, Wellde; Nt, Briggs; Eh, Sadun

doi:10.1093/milmed/131.suppl_9.859

Cited by 22 publications

(3 citation statements)

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“…Some delay in the prepatent period was detected as expected. This delay has been found by many researchers on different strains and species of Plasmodium (2, 3, 9,10,11 ) , and is inversely proportional to the size of the inoculum.…”

Section: Resultssupporting

confidence: 58%

Transfer of Adoptive Immunity to Plasmodium berghei: A Comparison of Routes of Injection*

Cabrera

Alger

1971

The Journal of Protozoology

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SYNOPSIS. The ability to protect rats against Plasmodium berghei by the transfer of spleen cells by various routes of injection was examined. Intraperitoneal and intravenous injections of cells taken from spleens of recovered rats transferred immunity. Intramuscular injection of the same material was unsuccessful. All injections were derived from the same pool of immune spleen cells and contained equal numbers of trypan blue‐excluding cells.

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Section: Resultssupporting

confidence: 58%

Transfer of Adoptive Immunity to Plasmodium berghei: A Comparison of Routes of Injection*

Cabrera

Alger

1971

The Journal of Protozoology

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“…would protect a susceptible host from severe infection. Antibody transfers some passive protection against P. berghei but, as in the present study, the major effect is to delay detection of parasites, the effect of the ultimate parasitemia on the fate of the host being much less apparent (4, 20). Nevertheless it could be that passively transferred antibody is not in adequate concentration where it is required, and that antibody-producing cells, when sited in the spleen of the recipient, could damage parasites directly or opsonise parasitized cells preparatory to phagocytosis.…”

Section: Discussionmentioning

confidence: 56%

Adoptive Transfer of Immunity to Plasmodium berghei

Roberts

Tracey-Patte

1969

The Journal of Protozoology

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SYNOPSIS. Immunity to P. berghei in rats was transferred adoptively with spleen cells but not with bone marrow cells, thymus cells, peripheral lymph node cells or thoracic duct lymphocytes from immune donors. The parasite multiplies at the same rate in control and protected rats but when about 10% of host red cells are infected the number of infected cells in protected rats decreases rapidly whereas control rats attain high parasitemias and die. Serum from immune donors delays the onset of parasitemia but does not affect its ultimate course or the fate of the recipient.

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“…Preliminary observations in our laboratory measuring the MATERIALS AND METHODS Plasmodium berghei yoeli was maintained by serial passage in female mice (15). Reticulocytosis (80%) was induced according to Crystal et al (16).…”

mentioning

confidence: 99%

Influence of 9-beta-D-arabinofuranosyladenine on total protein synthesis and on differential gene expression of unique proteins in the rodent malarial parasite Plasmodium berghei.

Ilan¹,

Pierce²,

Miller³

1977

Proc. Natl. Acad. Sci. U.S.A.

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The antibiotic 9-beta-D-arabinofuranosyladenine is a drug with a broad spectrum of activity against animal viruses, with little or no effect on mammalian cells, when administered in vivo or in vitro. Here we report that the antibiotic markedly inhibited the incorporation of [35S]methionine into malarial protein. Inhibition was apparent when the parasites were either exposed to the drug in vivo during the course of infection or incubated with the drug in vitro. Moreover, the antibiotic induced pronounced changes in the spectrum of proteins synthesized. Some proteins that are prominently apparent in the control disappear from the drug-treated parasites; others specific for drug-treated parasites appear, indicating changes in the commitment for gene expression as manifested by the appearance of the final protein product. Proteins synthesized were analyzed by two-dimensional polyacrylamide gels; the first dimension used isoelectric focusing in cylinder gels and the second dimension used electrophoresis in a lithium dodecyl sulfate slab gel. Proteins were visualized by radioautography.

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Susceptibility to Plasmodium berghei: Parasitological, Biochemical and Hematological Studies in Laboratory and Wild Mammals

Cited by 22 publications

References 0 publications

Transfer of Adoptive Immunity to Plasmodium berghei: A Comparison of Routes of Injection*

Transfer of Adoptive Immunity to Plasmodium berghei: A Comparison of Routes of Injection*

Adoptive Transfer of Immunity to Plasmodium berghei

Influence of 9-beta-D-arabinofuranosyladenine on total protein synthesis and on differential gene expression of unique proteins in the rodent malarial parasite Plasmodium berghei.

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