Susceptibility to Fluoroquinolones of <emph type="ital">Vibrio cholerae</emph> O1 Isolated From Diarrheal Patients in Zimbabwe

Antimicrobial Drug Resistance ofVibrio cholerae, Democratic Republic of the Congo

“…However, a risk for emergence and spread of fluoroquinolone-resistant strains exists, as has been shown elsewhere in Africa ( 13 ). Because resistance to nalidixic acid is frequently associated with decreased susceptibility to fluoroquinolones, nalidixic acid resistance must be detected to monitor the emergence of highly resistant strains ( 14 ).…”

Genomic diversity of 2010 Haitian cholera outbreak strains

“…Analysis of the gyrA and parC (VC1258 and VC2430, respectively, in Table S3) genes revealed two point mutations in the Haitian strains, i.e., a ser83ile substitution in gyrA and a ser85leu substitution in parC. Both point mutations are associated with quinolone resistance in clinical V. cholerae and have been reported in India and most recently in Nigeria and Cameroon (33)(34)(35)(36)(37). We observed the same point mutations in gyrA and parC in recent isolates from Zimbabwe (CP1038), Thailand (CP1042), and Bangladesh (CP1048).…”

Vibrio choleraeO1 Variant with Reduced Susceptibility to Ciprofloxacin, Western Africa

“…There is also concern for the strains isolated in this study because of their reduced susceptibility to ciprofloxacin. Although reduced susceptibility to fluoroquinolone is common in southern Asia ( 7 , 8 ), it was reported in Africa (Zimbabwe) only recently ( 9 ). Our findings, in addition to the report of Islam et al ( 9 ), indicate that V .…”

“…Although reduced susceptibility to fluoroquinolone is common in southern Asia ( 7 , 8 ), it was reported in Africa (Zimbabwe) only recently ( 9 ). Our findings, in addition to the report of Islam et al ( 9 ), indicate that V . cholera with reduced sensitivity to a fluoroquinolone is present in southern and western Africa.…”