Susceptibility to febrile malaria is associated with an inflammatory gut microbiome
Nathan Schmidt,
Kristin Van Den Ham,
Layne Bower
et al.
Abstract:Malaria is a major public health problem, but many of the factors underlying the pathogenesis of this disease are not well understood. Here, we demonstrate in Malian children that susceptibility to febrile malaria following infection with Plasmodium falciparum is associated with the composition of the gut microbiome prior to the malaria season. Gnotobiotic mice colonized with the fecal samples of malaria-susceptible children had a significantly higher parasite burden following Plasmodium infection compared to … Show more
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