Susceptibility to Antimicrobial Agents of Streptococcus suis Capsular Type 2 Strains Isolated from Pigs

Šeol, Branka; Kelnerić, Željko; Hajsig, Danko; Madić, Josip; Naglić, Tomo

doi:10.1016/s0934-8840(96)80067-3

Cited by 13 publications

(3 citation statements)

References 12 publications

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“…The strong selection pressure caused by widespread use of antimicrobials in pig farming is expected to give rise to AMR in S. suis. Consistent with this, several phenotypic studies show high MICs for each of the major classes of antibiotics in one or more S. suis collections [11][12][13][14][15]. In addition, there have been demonstrations of individual resistance determinants affecting MIC in S. suis [16][17][18], and also some mining of S. suis genome collections for known resistance determinants [19][20][21].…”

Section: Introductionmentioning

confidence: 60%

Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

et al. 2021

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Background Antimicrobial resistance (AMR) is among the gravest threats to human health and food security worldwide. The use of antimicrobials in livestock production can lead to emergence of AMR, which can have direct effects on humans through spread of zoonotic disease. Pigs pose a particular risk as they are a source of zoonotic diseases and receive more antimicrobials than most other livestock. Here we use a large-scale genomic approach to characterise AMR in Streptococcus suis, a commensal found in most pigs, but which can also cause serious disease in both pigs and humans. Results We obtained replicated measures of Minimum Inhibitory Concentration (MIC) for 16 antibiotics, across a panel of 678 isolates, from the major pig-producing regions of the world. For several drugs, there was no natural separation into ‘resistant’ and ‘susceptible’, highlighting the need to treat MIC as a quantitative trait. We found differences in MICs between countries, consistent with their patterns of antimicrobial usage. AMR levels were high even for drugs not used to treat S. suis, with many multidrug-resistant isolates. Similar levels of resistance were found in pigs and humans from regions associated with zoonotic transmission. We next used whole genome sequences for each isolate to identify 43 candidate resistance determinants, 22 of which were novel in S. suis. The presence of these determinants explained most of the variation in MIC. But there were also interesting complications, including epistatic interactions, where known resistance alleles had no effect in some genetic backgrounds. Beta-lactam resistance involved many core genome variants of small effect, appearing in a characteristic order. Conclusions We present a large dataset allowing the analysis of the multiple contributing factors to AMR in S. suis. The high levels of AMR in S. suis that we observe are reflected by antibiotic usage patterns but our results confirm the potential for genomic data to aid in the fight against AMR.

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Section: Introductionmentioning

confidence: 60%

Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

et al. 2021

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“…In Serbia, a recent prevalence study was published using isolates from swab samples taken from dead animals, clinically healthy pigs, slaughterhouse pig carcasses and butchers' knives, but it was impossible to associate corresponding serotypes to the diseased animals only. 87 In Croatia, only one study pertaining to the antimicrobial susceptibility of S. suis type 2 isolates was published, 88 but no epidemiological studies on the distribution of serotypes is available. Moreover, in Greece and Poland, where human cases have been reported, there are still no pig data available.…”

Section: Worldwide Distribution Of Serotypesmentioning

confidence: 99%

Streptococcus suis, an important pig pathogen and emerging zoonotic agent—an update on the worldwide distribution based on serotyping and sequence typing

Goyette-Desjardins

Auger

et al. 2014

Emerging Microbes & Infections

544

836

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Streptococcus suis is an important pathogen causing economic problems in the pig industry. Moreover, it is a zoonotic agent causing severe infections to people in close contact with infected pigs or pork-derived products. Although considered sporadic in the past, human S. suis infections have been reported during the last 45 years, with two large outbreaks recorded in China. In fact, the number of reported human cases has significantly increased in recent years. In this review, we present the worldwide distribution of serotypes and sequence types (STs), as determined by multilocus sequence typing, for pigs (between 2002 and 2013) and humans (between 1968 and 2013). The methods employed for S. suis identification and typing, the current epidemiological knowledge regarding serotypes and STs and the zoonotic potential of S. suis are discussed. Increased awareness of S. suis in both human and veterinary diagnostic laboratories and further establishment of typing methods will contribute to our knowledge of this pathogen, especially in regions where complete and/or recent data is lacking. More research is required to understand differences in virulence that occur among S. suis strains and if these differences can be associated with specific serotypes or STs.

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“…However, treatment failure in streptococcal infections is reported worldwide due to the emergence of strains resistant to FQs and other antibiotics in recent years. Such multidrug resistant streptococcal strains have become a universal problem and have severe consequences for pigs and for human health (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of an ABC transporter and mutations of GyrA, GyrB, and ParC in contributing to high-level ciprofloxacin resistance in Streptococcus suis type 2

Yao

Shang

Huang

et al. 2014

BST

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Susceptibility to Antimicrobial Agents of Streptococcus suis Capsular Type 2 Strains Isolated from Pigs

Cited by 13 publications

References 12 publications

Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

Streptococcus suis, an important pig pathogen and emerging zoonotic agent—an update on the worldwide distribution based on serotyping and sequence typing

Overexpression of an ABC transporter and mutations of GyrA, GyrB, and ParC in contributing to high-level ciprofloxacin resistance in Streptococcus suis type 2

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