Susceptibility to 18 drugs and multidrug resistance of Arcobacter isolates from different sources within the Czech Republic

Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants

“…Our results are in agreement with those obtained by Rathlavath et al (2017) on the 147 A. butzleri isolates from seafood (40 isolates were from shellfish) and coastal water, which were all sensitive to these three antibiotics. Susceptibility to these antibiotics is also consistent to that found by other authors who reported susceptibility to streptomycin and/or gentamicin and/or kanamycin for the great majority (96.4–100%) of A. butzleri isolated from shellfish [gentamicin (Collado et al, 2014)], water sources [gentamicin and streptomycin (Šilha et al, 2017)] and other various sources [gentamicin (Kayman et al, 2012; Ferreira et al, 2013, 2017; Van den Abeele et al, 2016); gentamicin and streptomycin (Šilha et al, 2017); kanamycin and streptomycin (Kabeya et al, 2004); gentamicin, kanamycin and streptomycin (Rahimi, 2014)]. Aminoglycosides are proposed as antibiotics to be used in Arcobacter infections (Rahimi, 2014; Ferreira et al, 2016; Rathlavath et al, 2017).…”

“…The antimicrobial susceptibility of Arcobacter spp. isolated from various ecological niches has been investigated by several authors (Kabeya et al, 2004; Kayman et al, 2012; Ferreira et al, 2013, 2017; Scanlon et al, 2013; Collado et al, 2014; Rahimi, 2014; Yesilmen et al, 2014; Zacharow et al, 2015b; Aski et al, 2016; Van den Abeele et al, 2016; Elmali and Can, 2017; Rathlavath et al, 2017; Šilha et al, 2017; Soma et al, 2017; Vicente-Martins et al, 2018), but the lack of standardized protocols and interpretive criteria for the antimicrobial susceptibility testing (AST) of Arcobacter spp. is the major limitation for a comparable and univocal evaluation of antimicrobial resistance and susceptibility for these microorganisms (Ferreira et al, 2016).…”

“…Both strains are resistant to all the ß-lactam antibiotics tested (ampicillin, penicillin, and cefotaxime) (Table 6). The resistance of A. buzleri isolates to β-lactams is widespread in seafood and water sources (Collado et al, 2014; Rathlavath et al, 2017; Šilha et al, 2017) as well as in other environments (Kayman et al, 2012; Ferreira et al, 2013; Rahimi, 2014; Yesilmen et al, 2014; Zacharow et al, 2015b; Aski et al, 2016; Van den Abeele et al, 2016; Elmali and Can, 2017; Vicente-Martins et al, 2018). Rathlavath et al (2017) found that on 40 A. butzleri isolated from shellfish, 100% resulted resistant to cefotaxime and 70% to ampicillin, while among 81 A. butzleri isolated from fish, 98.7% was resistant to cefotaxime and 72.8% to ampicillin.…”

“…Moreover, of 26 A. butzleri isolated from coastal water, 100% was resistant to cefotaxime and 73% to ampicillin (Rathlavath et al, 2017). Šilha et al (2017) found that 94.4% of 18 A. butzleri isolated from water sources were resistant to ampicillin and 100% were resistant to penicillin G, while Collado et al (2014) found that 45.2% of 62 A. butzleri isolated from bivalve molluscs were resistant to ampicillin.…”

Virulence and antibiotic resistance plasticity ofArcobacter butzleri: insights on the genomic diversity of an emerging human pathogen

“…Although disease caused by A. butzleri may be self-limited, several case-studies reported the use of antibiotic treatment for intestinal and extra-intestinal infections, mainly from the classes of β-lactams, fluoroquinolones and macrolides [7,15]. However, the multidrug resistance levels reported may prompt to a possible compromise of the treatment of infections caused by A. butzleri, with multidrug resistance rates ranging from 20 to 93.8 % among isolates from animals, food products, environment and human samples [16][17][18][19][20][21].…”