Susceptibility pattern of methicillin resistance Staphylococcus aureus (MRSA) by flow cytometry analysis and characterization of novel lead drug molecule from Streptomyces species

Govindarajan, Ganesan; Mullick, Priya; Raj, Babu Arulmani Samuel; Kumar, Pachaiyappan Saravana; Al-Ansari, Mysoon M.; Ilavenil, Soundharrajan; Solomon, Robinson David Jebakumar

doi:10.1016/j.jiph.2021.11.001

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…In addition, the isolates have been stored for months, thus it is suspected that the ability of endophytic bacterial isolates to produce compounds secondary actives with antibacterial effects will also decrease significantly to even nothing (Yuwita, 2021). The combination of the several reasons above could answer why endophytic bacterial isolates have absolutely no inhibition against the MDR bacteria, coupled with other factor that supports the absence of inhibition of endophytic bacterial isolates against the pathogenic bacteria, that is, MDR S. aureus and S. epidermidis as pathogenic bacteria in this study are resistant bacteria and have been proven by the result of susceptibility analysis by Maluku Province Health Laboratory Center, thus allowing their cell walls to become resistant (Monowat & Bhore, 2014;Govindarajan et al, 2021). The MDR S. aureus and S. epidermidis are a group of Gram-positive bacteria that are resistant to more than one antibiotic (Dross-Anderson & Elhassanny, 2018;Monowar & Bhore, 2014).…”

Section: Discussionmentioning

confidence: 76%

The potential of endophytic bacteria isolated from atung fruit seeds as antibacterial against skin pathogens

Yunita

Mantong

Rahawarin

2023

BIO

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Antibiotic resistance is one of the biggest threats to global health today. Estimated by 2050, antibiotic resistance will cause around 10 million deaths per year if alternative treatments have not been identified. This study was aimed to determine the potential of endophytic bacterial isolates from the seeds of atung fruit (Parinarium glaberrimum Hassk) as an antibacterial against skin pathogens Cutibacterium acnes and MDR Staphylococcus aureus, and Staphylococcus epidermidis. This research was a descriptive observational research with laboratory experimental methods. This study used isolates of endophytic bacteria isolated from the seeds of atung fruit which were tested with pathogenic bacteria. The results showed that 2 of 7 endophytic bacterial isolates were able to inhibit the growth of C. acnes with clear zone diameter of 4 mm and 9 mm, respectively, yet couldn’t able to inhibit MDR S. aureus and S. epidermidis. This study concluded that the 2 isolates (isolate BBA5 and BBA9) could have potential as antibacterial against C. acnes. While 5 other isolates had not been able to inhibit the whole pathogenic bacteria tested. An optimization is necessary in an effort to develop these isolates as antibacterial.

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Section: Discussionmentioning

confidence: 76%