Susceptibility of young and adult rat kidneys to impacts of mosquito coil fumes

Abdrabouh, Abeer E.

doi:10.1080/2314808x.2020.1839850

Cited by 2 publications

(3 citation statements)

References 23 publications

(24 reference statements)

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“…After an acclimation period of a week, each age group was randomly subdivided into two groups, each of 10 rats: control young (CN-Y) and exposed young (EX-Y) groups, as well as control adult (CN-A) and exposed adult (EX-A) groups. Control groups inhaled ambient air, while exposed groups were allowed to inhale mosquito coil smoke in an exposure chamber of dimensions 1.5 × 0.9 × 2.1 m 3 previously described in Abdrabouh ( 2021 ) for 6 h (8 am–2 pm)/day, 6 days/week for 4 weeks.…”

Section: Methodsmentioning

confidence: 99%

“…A large population is routinely using mosquito coils on daily bases in closed environment to get rid of mosquito biting in complete unawareness of the potential hazard impact, especially during summer (Karim et al 2020 ; Anyabolu et al 2021 ). Due to the economic affordability and easy market accessibility to this type of mosquito repellent, it is widely used in Asia, South America, and Africa, including Egypt, especially in rural areas (Abdrabouh 2021 ). Approximately 2 billion people are exposed to elevated smoke resulting from incomplete biomass combustion of 50 billion mosquito coils burned, resulting in indoor air pollution (Syed et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke

Abdrabouh

2023

Environ Sci Pollut Res

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Mosquito coil repellents are well-known indoor air pollutant with significant health concerns. The present study investigated the toxic effects of mosquito coil smoke on the heart of young and adult male rats. The animals were subjected to the smoke for 6 h/day, 6 days/week, for 4 weeks. Within the first hour after lighting the coil, significant amounts of formaldehyde, total volatile organic compounds, and particulate matter (PM2.5 and PM10) were detected. Both exposed ages, particularly the young group, showed a significant increase in the activities of serum aspartate aminotransferase, lactate dehydrogenase, creatine kinase-MB, and the levels of troponin I, myoglobin, Na+ levels, lipid profile, and inflammatory markers (interleukin-6 and C-reactive protein) as well as a significant decrease in K+ levels and cardiac Na–K ATPase activity, indicating development of cardiac inflammation and dysfunction. Furthermore, the toxic stress response was validated by significant downregulation at expression of the detoxifying enzyme cytochrome p450. Histopathological studies in both age groups, especially the young group, revealed cardiomyocyte degeneration and necrotic areas. Moreover, upregulation at the pro-apoptotic markers, caspase3, P53, and cytochrome C expressions, was detected by immunohistochemical approach in heart sections of the exposed groups. Finally, the myocardial dysfunctional effects of the coil active ingredient, meperfluthrin, were confirmed by the docking results which indicated a high binding affinity of meperfluthrin, with Na–K ATPase and caspase 3. In conclusion, both the young and adult exposed groups experienced significant cardiac toxicity changes evidenced by cell apoptosis and histopathological alterations as well as disruption of biochemical indicators. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke

Abdrabouh

2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…A large population is routinely using mosquito coils on daily bases in closed environment to get rid of mosquito biting in complete unawareness of the potential hazards impact, especially during summer (Karim et al 2020;Anyabolu et al 2021). Due to the economic affordability and easy market accessibility to this type of mosquito repellent, it is widely used in Asia, South America, and Africa, including Egypt, especially in rural areas (Abdrabouh 2021). Approximately 2 billion people are exposed to elevated smoke resulting from incomplete biomass combustion of 50 billion mosquito coils burned, resulting in indoor air pollution (Syed et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke.

Abdrabouh

2023

Preprint

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Mosquito coil repellents are well known indoor air pollutant with significant health concerns. The present study investigated the toxic effects of mosquito coil smoke on the heart of young and adult male rats. The animals were subjected to the smoke for 6 hours/day, 6 days/week, for 4 weeks. Within the first hour after lighting the coil, significant amounts of formaldehyde, total volatile organic compounds, and particulate matter (PM2.5 & PM10) were detected. Both exposed ages; particularly the young group, showed a significant increase in the activities of serum aspartate aminotransferase, lactate dehydrogenase, creatine kinase-MB, and the levels of troponin I, myoglobin, Na+ levels, lipid profile, and inflammatory markers (interleukin-6 and C-reactive protein) as well as a significant decrease in K+ levels and cardiac Na-K ATPase activity indicating development of cardiac inflammation and dysfunction. Furthermore, the toxic stress response was validated by significant downregulation at expression of the detoxifying enzyme cytochrome p450. Histopathological studies in both age groups, especially the young group, revealed cardiomyocytes degeneration, necrotic areas, and extensive collagen deposition in heart tissue. Myocardial dysfunction was furtherly confirmed by the histochemical findings of reduced glycogen and protein contents, and upregulation at the pro-apoptotic markers P53, cytochrome C and caspase-3 expressions as detected by immunohistochemical approach in heart sections of the exposed groups. Finally, the myocardial dysfunctional effects of the coil active ingredient, meperfluthrin, was confirmed by the docking results which indicated a high binding affinity of meperfluthrin, with Na-K ATPase and caspase-3. In conclusion, both the young and adult exposed groups experienced significant cardiac toxicity changes evidenced by cell apoptosis and histopathological alterations as well as, disruption of biochemical indicators.

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Susceptibility of young and adult rat kidneys to impacts of mosquito coil fumes

Cited by 2 publications

References 23 publications

Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke

Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke

Toxicological and histopathological alterations in the heart of young and adult albino rats exposed to mosquito coil smoke.

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