Susceptibility of XPD and hOGG1 genetic variants to prostate cancer

Zhou, Cheng; Xie, Liping; Lin, Yiwei; Yang, Kai; Mao, Qinan; Cheng, Yufeng

doi:10.3892/br.2013.123

Cited by 16 publications

(16 citation statements)

References 27 publications

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“…There is a possibility of a type II error in this part of the analysis probably due to insufficient power. hOGG1 Ser326cys polymorphism has been shown to be significantly associated with other cancers, namely nasopharynx [20], esophageal [43], lung [44] and prostate cancer [45]. The ability of wildtype hOGG1 Ser326 to suppress mutagenesis was found to be stronger than the variant hOGG1 Cys326 [15].…”

Section: Discussionmentioning

confidence: 94%

Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC

Eng-Zhuan¹,

Munn-Sann²,

Pp³

et al. 2017

J Mol Genet Med

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Background: Nasopharyngeal carcinoma (NPC) is a rare form of cancer. NPC is the 4th most common cancer in Malaysia and the incidence rate for Malaysian Chinese is exceptionally high compared to other races. NPC is considered as a relatively radiosensitive tumor and patients diagnosed at early stages tend to survive longer compared to those who with advanced disease. Given that early symptoms of NPC are non-specific, and that the nasopharynx is relatively inaccessible, less invasive screening methods such as biomarker screening might be the key to improve NPC survival and management.Methodology: A matched case-control study was conducted to investigate the effect of hOGG1 Ser326Cys, ITGA2 C807T and TNF-α -308G>A polymorphisms on the risk of nasopharyngeal carcinoma and all-cause survival. hOGG1 gene encodes for a DNA glycosylase, a protein that is involved in DNA repair. ITGA2 is the alpha subunit of the transmembrane receptor integrin and is mainly responsible for cell-cell and cell-extracellular matrix interaction. TNF-α is a cytokine that is released by immune cells during inflammation. Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was used to process DNA genotyping studies involving all aforementioned gene polymorphisms. Conditional logistic regression was used for the analysis of NPC risk on gene polymorphisms, controlling for cigarette smoking, salted fish and alcohol consumption.Results: Conditional logistic regression showed that NPC cases were more likely to ever consume salted fish during childhood compared to controls (OR=1.80, 95% CI=1.32-2.46, p<0.01). Individuals with previous smoking history were also at higher risk of NPC (OR=1.96, 95% CI=1.37-2.81, p<0.01). No significant difference was found between NPC cases and controls for alcohol consumption. No significant association was observed between hOGG1 Ser326Cys, ITGA2 C807T, TNF-α -308G>A polymorphisms with NPC risk. Conclusion:None of the aforementioned polymorphisms showed significant association in increasing NPC risk individually.

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Section: Discussionmentioning

confidence: 94%

Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC

Eng-Zhuan¹,

Munn-Sann²,

Pp³

et al. 2017

J Mol Genet Med

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“… 16 Mutations in DNA repaired gene may lead to decrease or loss of its DNA repair capacity and confer the variation in susceptibility to diverse malignant tumors among individuals. Many studies have indicated that polymorphisms in DNA repair genes may modify the risk for cancer, such as esophageal cancer, breast cancer, glioma and prostate cancer, 17 - 20 while few studies reported the role of DNA repair genes and development of osteosarcoma. 21 …”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms of nucleotide excision repair and homologous recombination repair pathways and their role in the risk of osteosarcoma

Yin¹

2015

Pak J Med Sci

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Objective:To evaluate the influence of polymorphisms in nucleotide excision repair (NER) and homologous recombination repair (HRR) pathways on the development of osteosarcoma patients.Methods:Genotypes of ERCC1 rs11615 and rs3212986, ERCC2 rs1799793 and rs13181, NBN rs709816 and rs1805794, RAD51 rs1801320, rs1801321 and rs12593359, and XRCC3 rs861539 were conducted by Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) assay.Results:Total 148 osteosarcoma patients and 296 control subjects were collected from Taizhou First People’s Hospital. Conditional logistic regression analyses found that individuals carrying with GA+AA genotype of ERCC2 rs1799793 and GC+CC genotype of NBN rs1805794 were significantly associated with increased risk of osteosarcoma, and the ORs(95%CI) were 1.58(1.03-2.41) and 2.66(1.73-4.08), respectively. We found that GA+AA genotype of ERCC2 rs1799793 or GC+CC genotype of NBN rs1805794 were associated with an increased risk of osteosarcoma in females, with ORs(95%CI) of 2.42(1.20-4.87) and 2.01(1.07-4.23), respectively.Conclusion:Our results suggest that ERCC2 rs1799793 and NBN rs1805794 polymorphisms were associated with an increased risk for osteosarcoma, which suggests that NER and HRR pathways modulate the risk of developing osteosarcoma.

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“…Mirecka et al 12 showed that the Arg156Arg polymorphism has no relationship with PCa risk. However, the results reported by Zhou et al 13 indicated that Arg156Arg polymorphism increased the susceptibility to high-risk PCa. No meta-analysis has yet been conducted to explore the relationship between the Arg156Arg polymorphism in XPD and the risk of PCa.…”

Section: Introductionmentioning

confidence: 90%

Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms inXPDand the Risk of Prostate Cancer

Xiao

Zhang

et al. 2017

Technol Cancer Res Treat

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Prostate cancer is the most common solid cancer and genetic factors play important roles in its pathogenesis. XPD is one of the 8 core genes involved in the nucleotide excision repair pathway. The relationship between Asp312Asn, Lys751Gln, and Arg156Arg polymorphisms in XPD and prostate cancer risk is a controversial topic. Therefore, we conducted a meta-analysis to explore the relationship between these 3 polymorphisms and the risk of developing prostate cancer. We searched the electronic literature in PubMed and Google Scholar for all relevant studies (last updated January 1, 2017). The pooled odds ratios and 95% confidence intervals for the associations between the Asp312Asn, Lys751Gln, or Arg156Arg polymorphisms in XPD and prostate cancer risk were calculated. To evaluate the effects of specific study characteristics on the association of these 3 polymorphisms and prostate cancer risk, we performed subgroup analysis if 2 or more studies were available. After an extensive literature review, 7 publications regarding Asp312Asn genotype distribution with 8 case–controls, 9 publications regarding Lys751Gln genotype distribution with 10 case–controls, and 3 publications regarding Arg156Arg genotype distribution with 4 case–controls were selected. The results showed that Asp312Asn (odds ratio = 1.34, 95% confidence interval: 0.96-1.87, P = .000), Lys751Gln (odds ratio = 0.98, 95% confidence interval: 0.89-1.08, P = .986), and Arg156Arg (odds ratio = 1.05, 95% confidence interval: 0.91-1.22, P = .57) polymorphisms do not increase the risk of prostate cancer in the dominant model. Further, in the subgroup analysis by ethnicity, no relationships were observed between Lys751Gln and Arg156Arg polymorphisms and prostate cancer risk. However, stratified analysis by ethnicity revealed that Asp312Asn affects African (odds ratio = 1.57, 95% confidence interval: 1.06-2.33, P = .382) and Asian populations (odds ratio = 2.09, 95% confidence interval: 1.39-3.14, P = .396) in homozygote comparison. In conclusion, this meta-analysis suggests that there is no general association between the Asp312Asn, Lys751Gln, and Arg156Arg polymorphisms in XPD and prostate cancer susceptibility.

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Susceptibility of XPD and hOGG1 genetic variants to prostate cancer

Cited by 16 publications

References 27 publications

Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC

Association of hOGG1 Ser326Cys, ITGA2 C807T and TNF-A -308G>A Polymorphisms with the Risk of NPC

Single Nucleotide Polymorphisms of nucleotide excision repair and homologous recombination repair pathways and their role in the risk of osteosarcoma

Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms inXPDand the Risk of Prostate Cancer

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