Susceptibility of urine isolates of Staphylococcus saprophyticus to antimicrobial agents

Schneider, Paul F.; Riley, Thomas V.

doi:10.3109/00313029109060812

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…In Staphylococcus saprophyticus, TMP resistance has been reported in only 2% of 96 isolates studied (137). In our own material, 1% of 186 isolates studied were resistant to TMP-SULs and 9% were resistant to TMP (72).…”

Section: Spread Of Tmp and Sul Resistancementioning

confidence: 99%

Trimethoprim and sulfonamide resistance

Huovinen¹,

Sundström²,

Swedberg³

et al. 1995

Antimicrob Agents Chemother

442

314

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Section: Spread Of Tmp and Sul Resistancementioning

confidence: 99%

Trimethoprim and sulfonamide resistance

Huovinen¹,

Sundström²,

Swedberg³

et al. 1995

Antimicrob Agents Chemother

442

314

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“…11 Where susceptibility testing was not performed for Staphylococcus saprophyticus , we assumed trimethoprim susceptibility. 12 We focused on E. coli for genomic characterization as it is the most frequently isolated bacterium in urine.…”

Section: Methodsmentioning

confidence: 99%

Resistance to first-line antibiotic therapy among patients with uncomplicated acute cystitis in Melbourne, Australia: prevalence, predictors and clinical impact

Curtis,

Kwong,

Chaung

et al. 2023

JAC-Antimicrobial Resistance

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Background Australian guidelines recommend trimethoprim or nitrofurantoin as first-line agents for uncomplicated urinary tract infections (UTIs). Laboratory surveillance indicates high rates of trimethoprim resistance among urinary bacterial isolates, but there are scant local clinical data about risk factors and impact of trimethoprim resistance. Objectives To determine the prevalence, risk factors, mechanism and impact of resistance to first-line antibiotic therapy for uncomplicated UTIs in the community setting. Methods A prospective observational study from October 2019 to November 2021 in four general practices in Melbourne, Australia. Female adult patients prescribed an antibiotic for suspected or confirmed uncomplicated acute cystitis were eligible. Primary outcome was urine isolates with resistance to trimethoprim and/or nitrofurantoin. Results We recruited 87 participants across 102 UTI episodes with median (IQR) age of 63 (47–76) years. Escherichia coli was the most common uropathogen cultured (48/62; 77%); 27% (13/48) were resistant to trimethoprim (mediated by a dfrA gene) and none were resistant to nitrofurantoin. Isolates with resistance to a first-line therapy were more common among patients reporting a history of recurrent UTIs [risk ratio (RR): 2.08 (95% CI: 1.24–3.51)] and antibiotic use in the previous 6 months [RR: 1.89 (95% CI: 1.36–2.62)]. Uropathogen resistance to empirical therapy was not associated with worse clinical outcomes. Conclusions Resistance to trimethoprim is common in uncomplicated UTIs in Australia but may not impact clinical outcomes. Further research is warranted on the appropriateness of trimethoprim as empirical therapy, particularly for patients with antimicrobial resistance risk factors.

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