Susceptibility of Rats, Hamsters, and Mice to Carious Infection by Streptococcus mutans Serotype c and d Organisms

Abstract

Susceptibility of rats, hamsters, and mice to carious infection by S. mutans serotypes c and d was compared. S. mutans serotype c induced a similar level of carious lesions at experimental periods of 68, 82, and 98 d in rats, hamsters, and mice, respectively. On the other hand, S. mutans serotype d developed a high level of caries at those experimental periods in rats and hamsters, whereas in mice it showed weak caries activity.

Cariostatic Effect of Palatinose on Experimental Dental Caries in Rats

“…S. mutans MT8148R (serotype c), which had been isolated from a carious lesion of a Japanese child and made streptomycin resistant, was used in the present study. The time schedule of the experiment, the experimental procedures, and the maintenance of the exprimental animals were described in the previous papers (Hamada et al, 1978;Ooshima et al, 1981Ooshima et al, , 1983. The basic experimental diet used in this study was cariogenic diet #2000 containing 56% sucrose (Keyes and Jordan, 1964).…”

“…On the other hand, serotype g S. mutans 6715 has been found to be barely established when rats were fed diet containing palatinose or cornstarch ( Fig. 1; Ooshima et al, TABLE I Plaque deposition and caries development in SPF rats infected with S. mutans MT8148R 1, 2) Dental plaque index and caries score were evaluated according to Regolati and Hotz (1972) and Keyes (1944) as modified by Ooshima et al (1981Ooshima et al ( , 1983 1983). In the rats fed glucose, fructose, or a mixture of glucose and fructose, the recovery of strain 6715 was very low at the time of the first bacteriological examination after infection.…”

A Morphological Study of the First Molars in Mice with High or Low Caries Susceptibility

“…In many of the animal models used for studying dental caries, caries is induced by exogenous inoculation with cariogenic bacteria such as S. mutans (6,7,16). It is necessary to use mice as the model animal for genetic research into caries susceptibility, because nuce and humans show high homology in their genomic sequence, expression and function, and genetic analyses of mice have helped to identify many mutant genes for human genetic diseases (17, IS).…”

Inhibitory Effects of the Phytochemicals Partially Hydrolyzed Alginate, Leaf Extracts of Morus alba and Salacia Extracts on Dental Caries

“…After breeding, the molar is removed and the degree of dental caries is scored. The details of the experimental protocol have been described (Ooshima et al, 1981;Tsunehiro et al, 1997). The typical procedure of caries scoring is the Keyes Caries Score (Keyes, 1958).…”