Susceptibility of Mepraia spinolai and Triatoma infestans to different Trypanosoma cruzi strains from naturally infected rodent hosts

Campos, Ricardo; Acuña-Retamar, Mariana; Botto‐Mahan, Carezza; Ortíz, Sylvia; Cattan, Pedro E.; Solari, Aldo

doi:10.1016/j.actatropica.2007.07.005

Cited by 25 publications

(23 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data support molecular typing studies conducted on isolates from naturally infected degus from South America that showed natural infection with multiple genotypes including TcI, TcIIa, TcIIb, TcIId, and TcIIe singly, and some mixed infections (Yeo et al 2005; Campos et al 2007; Rozas et al 2007; Spotorno et al 2008). Interestingly, 2 genotypes, TcI and TcIIe, maintained parasitaemias during chronic infections (112 days p.i.)…”

Section: Discussionsupporting

confidence: 84%

Experimental infection of two South American reservoirs with four distinct strains ofTrypanosoma cruzi

et al. 2010

View full text Add to dashboard Cite

SUMMARY Trypanosoma cruzi (Tc), the causative agent of Chagas disease, is a diverse species with 2 primary genotypes, TcI and TcII, with TcII further subdivided into 5 subtypes (IIa–e). This study evaluated infection dynamics of 4 genetically and geographically diverse T. cruzi strains in 2 South American reservoirs, degus (Octodon degus) and grey short-tailed opossums (Monodelphis domestica). Based on prior suggestions of a genotype-host association, we hypothesized that degus (placental) would more readily become infected with TcII strains while short-tailed opossums (marsupial) would be a more competent reservoir for a TcI strain. Individuals (n = 3) of each species were intraperitoneally inoculated with T. cruzi trypomastigotes of TcIIa [North America (NA)-raccoon (Procyon lotor) origin], TcI [NA-Virginia opossum (Didelphis virginiana)], TcIIb [South America (SA)-human], TcIIe (SA-Triatoma infestans), or both TcI and TcIIa. Parasitaemias in experimentally infected degus peaked earlier (7–14 days post-inoculation (p.i.)) compared with short-tailed opossums (21–84 days p.i.). Additionally, peak parasitaemias were higher in degus; however, the duration of detectable parasitaemias for all strains, except TcIIa, was greater in short-tailed opossums. Infections established in both host species with all genotypes, except for TcIIa, which did not establish a detectable infection in short-tailed opossums. These results indicate that both South American reservoirs support infections with these isolates from North and South America; however, infection dynamics differed with host and parasite strain.

show abstract

Section: Discussionsupporting

confidence: 84%

Experimental infection of two South American reservoirs with four distinct strains ofTrypanosoma cruzi

et al. 2010

View full text Add to dashboard Cite

show abstract

“…cruzi showed differences in susceptibility [83] and even suggested that the strains are pathogenic and induce more or less deleterious effects in bugs [84]. Few studies relate comparisons of DTUs in experimental infections in a single triatomine species.…”

Section: Discussionmentioning

confidence: 99%

Over Six Thousand Trypanosoma cruzi Strains Classified into Discrete Typing Units (DTUs): Attempt at an Inventory

2016

View full text Add to dashboard Cite

Trypanosoma cruzi, the causative agent of Chagas disease, presents wide genetic diversity. Currently, six discrete typing units (DTUs), named TcI to TcVI, and a seventh one called TcBat are used for strain typing. Beyond the debate concerning this classification, this systematic review has attempted to provide an inventory by compiling the results of 137 articles that have used it. A total of 6,343 DTU identifications were analyzed according to the geographical and host origins. Ninety-one percent of the data available is linked to South America. This sample, although not free of potential bias, nevertheless provides today’s picture of T. cruzi genetic diversity that is closest to reality. DTUs were genotyped from 158 species, including 42 vector species. Remarkably, TcI predominated in the overall sample (around 60%), in both sylvatic and domestic cycles. This DTU known to present a high genetic diversity, is very widely distributed geographically, compatible with a long-term evolution. The marsupial is thought to be its most ancestral host and the Gran Chaco region the place of its putative origin. TcII was rarely sampled (9.6%), absent, or extremely rare in North and Central America, and more frequently identified in domestic cycles than in sylvatic cycles. It has a low genetic diversity and has probably found refuge in some mammal species. It is thought to originate in the south-Amazon area. TcIII and TcIV were also rarely sampled. They showed substantial genetic diversity and are thought to be composed of possible polyphyletic subgroups. Even if they are mostly associated with sylvatic transmission cycles, a total of 150 human infections with these DTUs have been reported. TcV and TcVI are clearly associated with domestic transmission cycles. Less than 10% of these DTUs were identified together in sylvatic hosts. They are thought to originate in the Gran Chaco region, where they are predominant and where putative parents exist (TcII and TcIII). Trends in host-DTU specificities exist, but generally it seems that the complexity of the cycles and the participation of numerous vectors and mammal hosts in a shared area, maintains DTU diversity.

show abstract

“…Data gathered using the “transmissibility approach” suggest that there are differences in vectorial capacity among different species of triatomines, increased transmissibility when T. cruzi strains and triatomine bugs from the same region are involved, and differences in transmissibility for each parasite lineage in the same vector species ( T. infestans ) [16, 30, 31]. Serial xenodiagnosis performed on dogs showed that vectors from a given area are more susceptible to local strains of T. cruzi [31].…”

Section: Interactions Within the Systemmentioning

confidence: 99%

Trypanosoma cruzi: adaptation to its vectors and its hosts

2009

View full text Add to dashboard Cite

American trypanosomiasis is a parasitic zoonosis that occurs throughout Latin America. The etiological agent, Trypanosoma cruzi, is able to infect almost all tissues of its mammalian hosts and spreads in the environment in multifarious transmission cycles that may or not be connected. This biological plasticity, which is probably the result of the considerable heterogeneity of the taxon, exemplifies a successful adaptation of a parasite resulting in distinct outcomes of infection and a complex epidemiological pattern. In the 1990s, most endemic countries strengthened national control programs to interrupt the transmission of this parasite to humans. However, many obstacles remain to the effective control of the disease. Current knowledge of the different components involved in elaborate system that is American trypanosomiasis (the protozoan parasite T. cruzi, vectors Triatominae and the many reservoirs of infection), as well as the interactions existing within the system, is still incomplete. The Triatominae probably evolve from predatory reduvids in response to the availability of vertebrate food source. However, the basic mechanisms of adaptation of some of them to artificial ecotopes remain poorly understood. Nevertheless, these adaptations seem to be associated with a behavioral plasticity, a reduction in the genetic repertoire and increasing developmental instability.

show abstract

Susceptibility of Mepraia spinolai and Triatoma infestans to different Trypanosoma cruzi strains from naturally infected rodent hosts

Cited by 25 publications

References 22 publications

Experimental infection of two South American reservoirs with four distinct strains ofTrypanosoma cruzi

Experimental infection of two South American reservoirs with four distinct strains ofTrypanosoma cruzi

Over Six Thousand Trypanosoma cruzi Strains Classified into Discrete Typing Units (DTUs): Attempt at an Inventory

Trypanosoma cruzi: adaptation to its vectors and its hosts

Contact Info

Product

Resources

About