Susceptibility of Lung Cancer with Polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 Genotypes in the Population of Inner Mongolia Region

Jiang, Xueyan; Chang, Fuhou; Bai, Tuya; Lv, Xiaoli; Wang, Minjie; Wang, Guang

doi:10.7314/apjcp.2014.15.13.5207

Cited by 16 publications

(21 citation statements)

References 22 publications

(20 reference statements)

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“…Recent studies also observed that the risk of cancers in smokers was modulated by CYP1A1 genetic variations (Guo et al, 2008;Sam et al, 2008;Liu et al, 2013;Jiang et al, 2014). However, these studies were conducted in a bi-modal manner (presence/absence) whereas our study was conducted on a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 71%

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

Singh

Choudhury²,

Kapfo³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 71%

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

Singh

Choudhury²,

Kapfo³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…; Jiang et al . ; Yang et al . ), we found no association between the variants of CYP1A1 MspI and lung cancer risk among non‐smokers (type B and type C combined vs. type A: OR = 1.09, 95% CI = 0.91–1.30, P = 0.682 for heterogeneity, Fig.…”

Section: Resultsmentioning

confidence: 97%

“…; Jiang et al . ; Yang et al . ) containing 2248 cases and 3079 controls were finally included in this meta‐analysis, and the detailed steps of the literature search are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…After a comprehensive search of online databases and references, 195 records were retrieved. By screening titles, abstracts and full articles of retrieved records, a total of 13 studies (Song et al 2001(Song et al , 2010Cai et al 2003;Wang et al 2003;Li et al 2005Li et al , 2012Ng et al 2005;Qian et al 2006;Gu et al 2007;Jin et al 2010;Chen et al 2012;Jiang et al 2014;Yang et al 2014) containing 2248 cases and 3079 controls were finally included in this meta-analysis, and the detailed steps of the literature search are shown in Figure 1. According to the original definition of included studies, 2599 smokers and 2522 non-smokers were identified.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…Genotype distribution data among smokers were available in 12 studies (Song et al 2001(Song et al , 2010Cai et al 2003;Wang et al 2003;Li et al 2005Li et al , 2012Qian et al 2006;Gu et al 2007;Jin et al 2010;Chen et al 2012;Jiang et al 2014;Yang et al 2014). Overall, a significantly elevated risk of lung cancer was associated with the variants of CYP1A1 MspI among smokers (type B and type C combined vs. type A: OR = 1.89, 95% CI = 1.15-3.11, P = 0.000 for heterogeneity, Fig.…”

Section: Smokersmentioning

confidence: 99%

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The interaction between smoking and CYP1A1 MspI polymorphism on lung cancer: a meta-analysis in the Chinese population

Zhang

Wang

et al. 2016

Eur J Cancer Care

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Many studies have examined the interaction between CYP1A1 MspI gene polymorphism and smoking for the risk of lung cancer risk in Chinese, but their results have been inconsistent. Therefore, a meta-analysis was performed to ascertain this issue. PubMed, Springer Link, Ovid and other Chinese databases were searched to include all the relevant studies. Smoking status was categorised as 'smokers' and 'non-smokers.' The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random effect model. Subgroup analyses according to ethnicity, source of control and geographical location were also conducted. This meta-analysis identified 13 studies containing 2248 lung cases and 3079 controls. Overall, a significant association between lung cancer and the variants of CYP1A1 MspI was found among smokers (type B and type C combined vs. type A: OR = 1.89, 95% CI = 1.15-3.11, P = 0.000 for heterogeneity), whereas not found among non-smokers. Similar to the overall results, stratified analyses showed that the increased risk of lung cancer was observed in population-based studies and north China among smokers (OR = 1.65, 95%CI = 1.03-2.66; OR = 2.00, 95% CI = 1.14-3.53). Our meta-analysis showed that there was an interaction between the CYP1A1 MspI and smoking on the risk of lung cancer in the Chinese population.

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CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case–control study

et al. 2015

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In first part of this study, a systematic review was designed to explore the involvement of CYP1A1 and GSTP1 genes in breast cancerogenesis. Based on systematic review, we designed a study to screen CYP1A1 and GSTP1 genes for mutation and their possible association with breast carcinogenesis. A total of 400 individuals were collected and analyzed by PCR-SSCP. After sequence analysis of coding region of CYP1A1 we identified eleven mutations in different exons of respective gene. Among these eleven mutations, ~3 folds increased breast cancer risk was found associated with Asp82Glu mutation (OR 2.99; 95% CI 1.26-7.09), with Ser83Thr mutation (OR 2.99; 95% CI 1.26-7.09) and with Glu86Ala mutation (OR 3.18; 95% CI 1.27-7.93) in cancer patients compared to controls. Furthermore, ~4 folds increase in breast cancer risk was found associated with Asp347Glu, Phe398Tyr and 5178delT mutations (OR 3.92; 95% CI 1.35-11.3) in patients compared to controls. The sequence analysis of GSTP1 resulted in identification of total five mutations. Among these five mutations, ~3 folds increase in breast cancer risk was observed associated with 1860G>A mutation, with 1861-1876delCAGCCCTCTGGAGTGG mutation (OR 2.70; 95% CI 1.10-6.62) and with 1861C>A mutation (OR 2.97; 95% CI 1.01-8.45) in cancer patients compared to controls. Furthermore, ~5 folds increase in breast cancer risk was associated with 1883G>T mutation (OR 4.75; 95% CI 1.46-15.3) and ~6 folds increase in breast cancer risk was found associated with Iso105Val mutation (OR 6.43; 95% CI 1.41-29.3) in cancer patients compared to controls. Our finding, based on systematic review and experimental data suggest that the polymorphic CYP1A1 and GSTP1 genes may contribute to risk of developing breast cancer.

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Susceptibility of Lung Cancer with Polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 Genotypes in the Population of Inner Mongolia Region

Cited by 16 publications

References 22 publications

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India

The interaction between smoking and CYP1A1 MspI polymorphism on lung cancer: a meta-analysis in the Chinese population

CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case–control study

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