Susceptibility of Group A<i>Streptococcus</i>to Antimicrobial Agents in Northern Israel: A Surveillance Study

Chazan, Bibiana; Raz, Raul; Edelstein, Hana; Kennes, Yoram; Gal, Vered; Colodner, Raul

doi:10.1089/mdr.2015.0040

Cited by 9 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Необоснованное назначение антибиотиков, неадек-ватно низкая доза, недостаточный курс лечения приводят к глобальному росту антибиотикорезистентности [7,15] и заражению резистентными микроорганизмами миллио-нов людей во всем мире. На сегодняшний день имеются сведения, что чаще всего тяжелое течение бактериальных инфекций и осложнений связано с развитием новых механизмов устойчивости флоры.…”

Section: бронхопульмонология и лорunclassified

“…На сегодняшний день имеются сведения, что чаще всего тяжелое течение бактериальных инфекций и осложнений связано с развитием новых механизмов устойчивости флоры. При условии, что в бли-жайшее время принципиально новых антибиотиков не будет, уже можно ожидать неэффективности терапии наи-более тяжелых пациентов [15].…”

Section: бронхопульмонология и лорunclassified

“…Большинство специалистов и медицинских сообществ, занимающихся проблемами острых тонзиллитов, сходят-ся во мнении, что только стрептококковые тонзиллиты требуют обязательного системного антибактериального лечения [15,20,21].…”

Section: в чем проблема?unclassified

“…15-30% детей и около 5-15% взрослых [17], необходимо постоянное обучение врачей, своевре-менное ознакомление их с изменениями чувствительно-сти флоры к антибиотикам и регулярный мониторинг результатов их работы [12,15,19].…”

Section: большинство специалистов и медицинских сообществ занимающихunclassified

“…В то же время израильские ученые утверждают, что на севере страны с 2004 г. до сих пор регистрируется высо-кая чувствительность БГСА к пенициллину, макролидам, клиндамицину и тетрациклину [15].…”

Section: лечение отunclassified

See 4 more Smart Citations

Acute Tonsillitis in Children: The Principle “Zap and It’s Done!”?

et al. 2018

View full text Add to dashboard Cite

Section: бронхопульмонология и лорunclassified

Section: в чем проблема?unclassified

Section: большинство специалистов и медицинских сообществ занимающихunclassified

Section: лечение отunclassified

See 3 more Smart Citations

Acute Tonsillitis in Children: The Principle “Zap and It’s Done!”?

et al. 2018

View full text Add to dashboard Cite

Prevalence, Antibiotic Susceptibility Pattern and Associated Factors of Streptococcus pyogenes among Pediatric Patients with Acute Pharyngitis in Sidama, Southern Ethiopia

Gebre,

Fenta,

Negash

et al. 2024

International Journal of Microbiology

View full text Add to dashboard Cite

Background. Streptococcus pyogenes is the most frequent cause of pharyngitis and skin infections in children and causes immune complications like rheumatic fever and rheumatoid heart disease (RHD), particularly in developing countries like Ethiopia. The aim of this study was to determine the prevalence, antibiotic resistance pattern, and associated factors of Streptococcus pyogenes among pediatric patients suspected of acute pharyngitis in Sidama Region, Southern Ethiopia. Methods. A cross‐sectional study was conducted on 213 acute pharyngitis suspected pediatric patients from April to September 2022 at Hawassa University Compressive Specialized Hospital and Yirgalem Hospital. Sociodemographic and clinical data were collected using a structured questionnaire. A throat swab was cultured to isolate S. pyogenes, and antimicrobial susceptibility testing was done using standard bacteriological techniques. Data were analyzed using SPSS version 25, and P value of <0.05 was considered as statistically significant. Result. Out of 213 throat swabs cultured, 22 (10.3%) with 95% CI (6.6–14.6%) were S. pyogenes positive. All isolates of S. pyogenes were sensitive to penicillin and amoxicillin. In contrast, 8 (36.4%) isolates exhibited resistance to tetracycline, 7 (31.8%) to ceftriaxone, 6 (27.3%) to erythromycin, and 5 (22.7%) isolates showed multidrug resistance. The presence of palatal petechiae (P = 0.037) and tonsillar swelling or exudate (P = 0.007) were significantly associated with S. pyogenes carriage in children suspected of having acute pharyngitis. Conclusion. In this study, the prevalence of S. pyogenes among children suspected with acute pharyngitis was low compared to other studies. The isolates showed a high level of resistance to commonly used antibiotics. Therefore, the treatment of pediatric acute S. pyogenes pharyngitis should depend on an antimicrobial susceptibility test. Furthermore, evaluation of S. pyogenes pediatric acute pharyngitis risk factors and tracking of antibiotic resistance are crucial in the controlling of pediatric acute S. pyogenes pharyngitis.

show abstract

Prevalence and antibiotics susceptibility profiles of Streptococcus pyogenes among pediatric patients with acute pharyngitis at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia

2021

View full text Add to dashboard Cite

Background Streptococcus pyogenes (S. pyogenes) is a Gram positive bacterium which is a leading cause of pharyngitis, skin and soft tissue infection and post streptococcal syndromes. Due to lack of β-lactamase enzyme production, it was considered universally susceptible to penicillin group and later generation of β-lactam antibiotics. As such, empirical treatment was common which might leads to development of antibiotics resistance. Therefore, the aims of this study were to determine the prevalence, antibiotics susceptibility profile; and associated factors of S. pyogenes among pediatric patients with acute pharyngitis in Felege Hiwot Comprehensive Specialized Hospital (FHCSH), Northwest Ethiopia. Methods Hospital based cross-sectional study was carried out on 154 pediatric patients, whose age ranged from 0 to 18 years old using consecutive convenient sampling technique from 1st February to 19th June 2020 at FHCSH. S. pyogenes were identified by throat swab culture on 5% sheep blood agar with an overnight incubation at 37 °C in candle jar containing 5% CO2. Gram stain, catalase test and bacitracin test were used to identify S. pyogenes. Then,the data were entered into EpiData version 3.1 and analyzed by SPSS version 20 software. Finally, stepwise, bivariable and multivariable logistic regressions were carried out for identifyying factors having significant ssociation (p<0.05) with acute pharyngitis. Results From the total throat swabs, 14 (9.1%) with (95% CI; 4.5–14.3) were culture positive for S. pyogenes. From these, all isolates were sensitive to penicillin and ampicillin. On the otherhand, 4 (35.7%), 4 (35.5%), 3 (21.4%), 2 (14.3%), 1 (7.1%), 7 (50.0%) and 1 (7.1%) isolates were resistant for ceftriaxone, vancomycin, erythromycin, tetracycline, chloramphenicol, clindamycin and levofloxacin, respectively. The presence of any smoker in home showed significant association with S. pyogenes acute pharyngitis. Furthermore, having tender lymphadenopathy and recurrence were clinical predictors for S. pyogenes acute pharyngitis (P < 0.05). Conclusion The prevalence of S. pyogenes was guaged at 9.1% which is considered as low prevalence. All S. pyogenes isolats remain sensitive to penicillin. However, resistance was reported to clindamycin 7 (50.0%), ceftriaxone 5 (35.7%) and erythromycin 3 (21.4%). The current practice of giving erythromycin, clindamycin instead of penicillin and ampicillin is againest the microbiology result. Therefore, current empirical treatment of acute pharyngitis shall take in to account the current evidences. Continuous surveillance of antibiotics resistance pattern of S. pyogenes for acute pharyngitis must be strengthen to improve the use of antibiotics in hospitals.

show abstract

Susceptibility of Group AStreptococcusto Antimicrobial Agents in Northern Israel: A Surveillance Study

Abstract: Continuous control of antimicrobials usage and periodic surveillance of susceptibility rates, together with educational programs and appropriate and targeted treatment protocols, are essential and highly recommended to keep these high susceptibility rates for as long as possible.

Cited by 9 publications

References 32 publications

Acute Tonsillitis in Children: The Principle “Zap and It’s Done!”?

Acute Tonsillitis in Children: The Principle “Zap and It’s Done!”?

Prevalence, Antibiotic Susceptibility Pattern and Associated Factors of Streptococcus pyogenes among Pediatric Patients with Acute Pharyngitis in Sidama, Southern Ethiopia

Prevalence and antibiotics susceptibility profiles of Streptococcus pyogenes among pediatric patients with acute pharyngitis at Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia

Contact Info

Product

Resources

About