Susceptibility of Florida <i>Aedes aegypti</i>
 and <i>Aedes albopictus</i>
 to dengue viruses from Puerto Rico

Alto, Barry W.; Smartt, Chelsea T.; Shin, Dong Ho; Bettinardi, David; Malicoate, Jolene; Anderson, Sheri L.; Richards, Stephanie L.

doi:10.1111/jvec.12116

Cited by 26 publications

(33 citation statements)

References 36 publications

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“…aegypti, but less susceptible to dissemination and transmission of the virus. [26][27][28][29] One study, which exposed mosquitoes by direct blood feeding on viremic patients, demonstrated a similar minimum 50% infectious dose (MID 50 ) required to infect both Ae. species, but Ae.…”

Section: Discussionmentioning

confidence: 99%

Limited Transmission Potential of Takeda’s Tetravalent Dengue Vaccine Candidate by Aedes albopictus

Dietrich

Ong

Stovall

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Recombinant live-attenuated chimeric tetravalent dengue vaccine viruses, TDV-1, -2, -3, and -4, contain the premembrane and envelope genes of dengue virus serotypes 1-4 in the replicative background of the attenuated dengue virus type-2 (DENV-2) PDK-53 vaccine strain. Previous results have shown that these recombinant vaccine viruses demonstrate limited infection and dissemination in and are unlikely to be transmitted by the primary mosquito vector of DENVs. In this report, we expand this analysis by assessing vector competence of all four serotypes of the TDV virus in, the secondary mosquito vector of DENVs. Our results indicate that these vaccine viruses demonstrate incompetence or defective infection and dissemination in these mosquitoes and will likely not be transmissible.

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Section: Discussionmentioning

confidence: 99%

Limited Transmission Potential of Takeda’s Tetravalent Dengue Vaccine Candidate by Aedes albopictus

Dietrich

Ong

Stovall

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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“…albopictus [149–152], Ae. aegypti [149,150,152–160] and Cx. quinquefasciatus [154], although the latter was not identified as a competent vector species experimentally.…”

Section: Resultsmentioning

confidence: 99%

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Jones

Kulkarni

Davidson

et al. 2019

Preprint

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27 Background 28 Three arthorpod-borne viruses (arboviruses) causing human disease have been the focus 29 of a large number of studies in the Americas since 2013 due to their global spread and 30 epidemiological impacts: Zika, dengue, and chikungunya viruses. A large proportion of 31 infections by these viruses are asymptomatic. However, all three viruses are associated with 32 moderate to severe health consequences in a small proportion of cases. Two mosquito species, 33 Aedes aegypti and Aedes albopictus, are among the world's most prominent arboviral vectors, 34 and are known primary vectors for all three viruses in the Americas. 35 Objectives 2 36 This review summarizes the state of the entomological literature surrounding the biology 37 and ecology of vectors of Zika, dengue and chikungunya viruses and factors affecting virus 38 transmission. The rationale of the review was to elucidate consensus and discord between 39 studies, and guide future research based on identified knowledge gaps. 40 Results 41 A total of 196 studies were included in the scoping review after initial screening and 42 subsequent exclusion of out-of-scope studies, secondary data publications, duplicate records, and 43 studies unavailable in English language. 44 Key findings 45 Temperature and humidity have the strongest impact on mosquito distribution and 46 dynamics, development of immatures and arborviral infection rates. Low socioeconomic status 47 and related factors, including poor infrastructure, inconsistent access to water, and high 48 household resident density, have been consistently associated with arbovirus vector occurrence. 49 Effects of interspecific competition on arboviral vector species is currently poorly understood. 50 Vector competence for Zika virus is well established for Ae. aegypti and Ae. albopictus. 51 Information on Zika virus vector transmission dynamics is sparse in contrast to the wealth of 52 research available for dengue and chikungunya viruses. 53 Conclusions 54Based on the internationally recognized urgency of Zika virus infection as a public health 55 concern, further research on arbovirus vectors and transmission dynamics is of pressing need. 56 57

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“…albopictus were collected from water-filled containers in Key West (Old Town historic district) and Vero Beach, FL, respectively. Mosquitoes were reared using methods described by Alto et al (2014) . Briefly, mosquitoes were kept at 26-28°C and 60-80% relative humidity in a climate controlled room and a light:dark cycle of 14:10 hours.…”

Section: Methodsmentioning

confidence: 99%

“…aegypti and Ae. albopictus ( Alto et al 2014 ). The results showed no significant differences in infection or dissemination rates between Ae.…”

mentioning

confidence: 99%

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Dengue serotype-specific immune response in Aedes aegypti and Aedes albopictus

Smartt

Shin

Alto

2017

Mem. Inst. Oswaldo Cruz

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BACKGROUNDDengue viruses (DENV) are considered one of the most important emerging pathogens and dengue disease is a global health threat. The geographic expansion of dengue viruses has led to co-circulation of all four dengue serotypes making it imperative that new DENV control strategies be devised.OBJECTIVESHere we characterize dengue serotype-specific innate immune responses in Aedes aegypti and Aedes albopictus using DENV from Puerto Rico (PR).METHODS Ae. aegypti and Ae. albopictus were infected with dengue serotype 1 and 2 isolated from Puerto Rico. DENV infected mosquito samples were collected and temporal change in expression of selected innate immune response pathway genes analyzed by quantitative real time PCR.FINDINGSThe Toll pathway is involved in anti-dengue response in Ae. aegypti, and Ae. albopictus. Infections with PR DENV- 1 elicited a stronger response from genes of the Toll immune pathway than PR DENV-2 in Ae. aegypti but in infected Ae. albopictus expression of Toll pathway genes tended to be similar between the serotypes. Two genes (a ribosomal S5 protein gene and a nimrod-like gene) from Ae. albopictus were expressed in response to DENV.MAIN CONCLUSIONSThese studies revealed a role for antiviral genes in DENV serotype-specific interactions with DENV vectors, demonstrated that infections with DENV-2 can modulate the Toll immune response pathway in Ae. aegypti and elucidated candidate molecules that might be used to interfere with serotype specific vector-virus interactions.

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Susceptibility of Florida Aedes aegypti and Aedes albopictus to dengue viruses from Puerto Rico

Cited by 26 publications

References 36 publications

Limited Transmission Potential of Takeda’s Tetravalent Dengue Vaccine Candidate by Aedes albopictus

Limited Transmission Potential of Takeda’s Tetravalent Dengue Vaccine Candidate by Aedes albopictus

Arbovirus Vectors of Epidemiological Concern in the Americas: A Scoping Review of Entomological Studies on Zika, Dengue and Chikungunya Virus Vectors

Dengue serotype-specific immune response in Aedes aegypti and Aedes albopictus

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