Susceptibility of environmental versus clinical strains of pathogenic Aspergillus

Araújo, Ricardo; Pina-Vaz, Cidália; Rodrigues, Acácio Gonçalves

doi:10.1016/j.ijantimicag.2006.09.019

Cited by 51 publications

(30 citation statements)

References 13 publications

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“…Similarly, A. nidulans clinical isolates are frequently found to be resistant to amphotericin B in vitro (281). On the other hand, evidence suggests that A. fumigatus amphotericin B resistance is unlikely to emerge during treatment for invasive aspergillosis, as amphotericin B MICs remain similar between isolates recovered from patients before and those recovered (14). It was proposed that the basis for the amphotericin B resistance of A. terreus may be the high level of catalase production compared with that of A. fumigatus, although this remains unconfirmed (63).…”

Section: Aspergillus Fumigatus Drug Resistance: the Polyenesmentioning

confidence: 99%

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

Shapiro

Robbins

Cowen

2011

Microbiol Mol Biol Rev

489

547

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SUMMARY Pathogenic fungi have become a leading cause of human mortality due to the increasing frequency of fungal infections in immunocompromised populations and the limited armamentarium of clinically useful antifungal drugs. Candida albicans , Cryptococcus neoformans , and Aspergillus fumigatus are the leading causes of opportunistic fungal infections. In these diverse pathogenic fungi, complex signal transduction cascades are critical for sensing environmental changes and mediating appropriate cellular responses. For C. albicans , several environmental cues regulate a morphogenetic switch from yeast to filamentous growth, a reversible transition important for virulence. Many of the signaling cascades regulating morphogenesis are also required for cells to adapt and survive the cellular stresses imposed by antifungal drugs. Many of these signaling networks are conserved in C. neoformans and A. fumigatus , which undergo distinct morphogenetic programs during specific phases of their life cycles. Furthermore, the key mechanisms of fungal drug resistance, including alterations of the drug target, overexpression of drug efflux transporters, and alteration of cellular stress responses, are conserved between these species. This review focuses on the circuitry regulating fungal morphogenesis and drug resistance and the impact of these pathways on virulence. Although the three human-pathogenic fungi highlighted in this review are those most frequently encountered in the clinic, they represent a minute fraction of fungal diversity. Exploration of the conservation and divergence of core signal transduction pathways across C. albicans , C. neoformans , and A. fumigatus provides a foundation for the study of a broader diversity of pathogenic fungi and a platform for the development of new therapeutic strategies for fungal disease.

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Section: Aspergillus Fumigatus Drug Resistance: the Polyenesmentioning

confidence: 99%

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

Shapiro

Robbins

Cowen

2011

Microbiol Mol Biol Rev

489

547

View full text Add to dashboard Cite

show abstract

“…While there are occasional reports of in vitro sensitivity to amphotericin B, the clinical paradigm has been to avoid therapy with amphotericin B due to concerns about resistance and repeated clinical failure against A. terreus invasive aspergillosis. A. nidulans has also been shown to have higher rates of amphotericin B resistance, both in vitro and clinically (4,90).…”

Section: Resistance To Drugs Exerting Cell Membrane Stress: the Polyenesmentioning

confidence: 99%

Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance

2008

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“…Based on both in vitro and clinical data, voriconazole has become the drug of choice for the treatment of invasive aspergillosis (1,8,10,12).…”

mentioning

confidence: 99%

“…The results of different in vitro studies showed that the vast majority of Aspergillus clinical strains are fully susceptible to the new triazoles, including voriconazole (1,2,8,9,(11)(12)(13). However, the antifungal activity of voriconazole may have changed since it began to be used in the clinical setting.…”

mentioning

confidence: 99%