Susceptibility of Domestic Goat (Capra aegagrus hircus) to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.351/Beta Variant

Fernández‐Bastit, Leira; Roca, Núria Bosch; Romero‐Durana, Miguel; Rodón, Jordi; Cantero, Guillermo; Castro, Oscar; López, Carlos Górriz; Pérez, Mónica; López, Rosa María; Carrillo, Jorge; Izquierdo-Useros, Nuria; Blanco, Julià; Clotet, Bonaventura; Pujols, Joan; Vergara‐Alert, Júlia; Segalés, Joaquím; Lorca-Oró, Cristina

doi:10.3390/v14092002

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…SARS-CoV-2 positivity rates were significantly higher in ruminants using PCR with the highest observed in sheep. This is in tandem with the findings of some authors who reported SARS-CoV-2 detection in ruminants [ 37 , 38 , 39 , 40 ]. Ulrich et al [ 37 ], Bosco-Lauth et al [ 38 ], and Fernández-Bastit et al [ 39 ] reported RT-PCR-positive nasal samples in cattle and goats.…”

Section: Discussionsupporting

confidence: 90%

“…This is in tandem with the findings of some authors who reported SARS-CoV-2 detection in ruminants [ 37 , 38 , 39 , 40 ]. Ulrich et al [ 37 ], Bosco-Lauth et al [ 38 ], and Fernández-Bastit et al [ 39 ] reported RT-PCR-positive nasal samples in cattle and goats. In addition, Gaudreault et al [ 40 ] demonstrated that sheep-derived kidney cells support SARS-CoV-2 replication and that viral RNA was also detected in sheep respiratory tract and lymphoid tissues.…”

Section: Discussionsupporting

confidence: 90%

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Detection of SARS-CoV-2 in Terrestrial Animals in Southern Nigeria: Potential Cases of Reverse Zoonosis

Happi,

Ayinla,

Ogunsanya

et al. 2023

Viruses

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Since SARS-CoV-2 caused the COVID-19 pandemic, records have suggested the occurrence of reverse zoonosis of pets and farm animals in contact with SARS-CoV-2-positive humans in the Occident. However, there is little information on the spread of the virus among animals in contact with humans in Africa. Therefore, this study aimed to investigate the occurrence of SARS-CoV-2 in various animals in Nigeria. Overall, 791 animals from Ebonyi, Ogun, Ondo, and Oyo States, Nigeria were screened for SARS-CoV-2 using RT-qPCR (n = 364) and IgG ELISA (n = 654). SARS-CoV-2 positivity rates were 45.9% (RT-qPCR) and 1.4% (ELISA). SARS-CoV-2 RNA was detected in almost all animal taxa and sampling locations except Oyo State. SARS-CoV-2 IgGs were detected only in goats from Ebonyi and pigs from Ogun States. Overall, SARS-CoV-2 infectivity rates were higher in 2021 than in 2022. Our study highlights the ability of the virus to infect various animals. It presents the first report of natural SARS-CoV-2 infection in poultry, pigs, domestic ruminants, and lizards. The close human–animal interactions in these settings suggest ongoing reverse zoonosis, highlighting the role of behavioral factors of transmission and the potential for SARS-CoV-2 to spread among animals. These underscore the importance of continuous monitoring to detect and intervene in any eventual upsurge.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Detection of SARS-CoV-2 in Terrestrial Animals in Southern Nigeria: Potential Cases of Reverse Zoonosis

Happi,

Ayinla,

Ogunsanya

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…In a study published in September 2022, SARS‐CoV‐2 was detected in experimentally infected goats in nasal swabs and tissues by PCR, and seroneutralisation was confirmed via ELISA. However, the viral amount and tissue distribution suggest a low susceptibility of goats, thus no relevant role of goats in the epidemiology of SARS‐Cov‐2 (Fernández‐Bastit et al, 2022 ).…”

Section: Assessmentmentioning

confidence: 99%

SARS‐CoV‐2 in animals: susceptibility of animal species, risk for animal and public health, monitoring, prevention and control

Nielsen¹,

Álvarez²,

Bicout³

et al. 2023

EFS2

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The epidemiological situation of SARS‐CoV‐2 in humans and animals is continually evolving. To date, animal species known to transmit SARS‐CoV‐2 are American mink, raccoon dog, cat, ferret, hamster, house mouse, Egyptian fruit bat, deer mouse and white‐tailed deer. Among farmed animals, American mink have the highest likelihood to become infected from humans or animals and further transmit SARS‐CoV‐2. In the EU, 44 outbreaks were reported in 2021 in mink farms in seven MSs, while only six in 2022 in two MSs, thus representing a decreasing trend. The introduction of SARS‐CoV‐2 into mink farms is usually via infected humans; this can be controlled by systematically testing people entering farms and adequate biosecurity. The current most appropriate monitoring approach for mink is the outbreak confirmation based on suspicion, testing dead or clinically sick animals in case of increased mortality or positive farm personnel and the genomic surveillance of virus variants. The genomic analysis of SARS‐CoV‐2 showed mink‐specific clusters with a potential to spill back into the human population. Among companion animals, cats, ferrets and hamsters are those at highest risk of SARS‐CoV‐2 infection, which most likely originates from an infected human, and which has no or very low impact on virus circulation in the human population. Among wild animals (including zoo animals), mostly carnivores, great apes and white‐tailed deer have been reported to be naturally infected by SARS‐CoV‐2. In the EU, no cases of infected wildlife have been reported so far. Proper disposal of human waste is advised to reduce the risks of spill‐over of SARS‐CoV‐2 to wildlife. Furthermore, contact with wildlife, especially if sick or dead, should be minimised. No specific monitoring for wildlife is recommended apart from testing hunter‐harvested animals with clinical signs or found‐dead. Bats should be monitored as a natural host of many coronaviruses.

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“…No significant onward transmission of the virus and establishment within these new host species could be detected [ 25 ]. Fortunately, livestock animals like pigs, chickens and goats [ 26 ] are not efficiently susceptible under experimental conditions [ 27 ]. Nevertheless, there is documentation of occasional spillover to animals like cattle [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV and SARS-CoV -2 cross-reactive antibodies in domestic animals and wildlife in Nigeria suggest circulation of sarbecoviruses

Agusi,

Schön,

Allendorf

et al. 2024

One Health

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Susceptibility of Domestic Goat (Capra aegagrus hircus) to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.351/Beta Variant

Cited by 4 publications

References 46 publications

Detection of SARS-CoV-2 in Terrestrial Animals in Southern Nigeria: Potential Cases of Reverse Zoonosis

Detection of SARS-CoV-2 in Terrestrial Animals in Southern Nigeria: Potential Cases of Reverse Zoonosis

SARS‐CoV‐2 in animals: susceptibility of animal species, risk for animal and public health, monitoring, prevention and control

SARS-CoV and SARS-CoV -2 cross-reactive antibodies in domestic animals and wildlife in Nigeria suggest circulation of sarbecoviruses

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