Abstract:Aim
Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of
CTLA-4
polymorphism with severity of the disease.
Methods
In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms −1661A/G of
CTLA-4.
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