Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1

Abstract

Introduction: Infection of pathogenic microorganisms is an important reason for autoimmune diseases (ADs). Interleukin-1 (IL-1) receptorassociated kinase-1 (IRAK1) is a key mediator in infection immunity, while the gene of IRAK1 is recognized as a risk gene in ADs. Three single nucleotide polymorphisms (SNPs) in IRAK1 (rs3027898, rs1059702, rs1059703) are considered to be associated with ADs risk. However, the results are conflicting. We conducted this study to get more precise estimations. Methodology: PubMed, OvidSP, and CNKI databases (published prior to August 2014) were searched, and data was extracted from eligible studies. The procedure of statistical analysis was performed using STATA 12.0 software. A random effect model or fixed effect model was chosen based on the between-study heterogeneities. Results: Of the studies involved, 11 studies included 10,705 cases (9,865 controls) for rs3027898, 9 studies included 15,005 cases (14,997 controls) for rs1059702, and 7 studies included 8,115 cases (6,815 controls) for rs1059703. Overall, the results showed that there were significant associations with ADs risk in three genetic models for rs3027898 and in four genetic models for rs1059702, but in neither model for rs1059703. Moreover, in stratified analyses, different extents of associations were found in some different genetic models for all three SNPs. Conclusion: Our data demonstrated that these three SNPs (rs3027898, rs1059702, rs1059703) in IRAK1 were associated with ADs risk.

Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to the Short-Tail Phenotype

“…The specific molecular mechanism functioning in the short-tail phenotype remains to be elucidated; however, we believe that the mutated T gene plays an important role in regulating this phenotype. Of the nine investigated genes, BCAR3 ( Agthoven et al 1998 ), FNBP1L ( Huett et al 2009 ), IRAK1 ( Li et al 2015 ), CUL5 ( Byrd et al 1997 ), and RAB39A ( Seto et al 2013 ) are related to the immune system; MECP2 ( Tao et al 2009 ) and SLC35F2 ( Sonuga-Barke 2013 ) are related to neurodevelopment; and LCORL ( Signer-Hasler et al 2012 ) is related to skeletal frame size. Only the T gene is related to development of the spine, and this gene seems to be associated with a short-tail phenotype in mice ( Beddington et al 1992 ).…”

Prognostic Value and Clinicopathological Significance of p-stat3 Among Gastric Carcinoma Patients

“…Heterogeneity among studies was assessed using I 2 statistics, If I 2 > 50%, it represented obvious heterogeneity between studies, we will use a random effects model, otherwise, a fixed effects model will be used. 23 We conducted subgroup analyses to explore the potential heterogeneity among studies and the difference between subgroups was detected by meta-regression analysis. Sensitivity analysis was performed to investigate the sources of heterogeneity and stability of results.…”

Association of IRAK1 Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study

“…Furthermore, it was reported that a common variant in miR-146a reduces mature miRNA expression and predisposes to PTC (10). It is worth mentioning that miR-146a is a microRNA that targets IRAK1 gene, of which the variant rs3027898 has been associated with immune diseases by our and other groups (10)(11)(12)(13)(14). Additionally, an emerging body of literature shows that altered IRAK1 expression predisposes to inflammatory diseases, autoimmune diseases, solid tumors and hematological malignancies, which may explain the focus on IRAK1 inhibitors in preclinical and clinical studies (15,16).…”