Susceptibility of a potential animal model for pathological anxiety to chronic mild stress

Salomons, Amber R.; Kortleve, Tessa; Reinders, Niels R.; Kirchhoff, Susanne; Arndt, Saskia S.; Ohl, Frauke

doi:10.1016/j.bbr.2010.01.050

Cited by 22 publications

(15 citation statements)

References 49 publications

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“…4). 129P3 mice revealed rapidly decreasing latencies to approach all odour cups after a few training trials in both odour conditioning tasks, showing that 129P3 mice are able to learn the spatial location of a reward, a finding that confirms earlier results of our lab showing that these mice are relatively fast in learning the location of reward in the modified hole board test [30,47]. However, 129P3 mice did not seem to build any negative association with the odour predictive for the bitter-tasting almond piece readily as indicated by comparable response times to different odours in the test session.…”

Section: Discussionsupporting

confidence: 84%

“…Initially in our first experiment a one-trial learning procedure was applied (one NEG trial) in order to minimize the number of aversive trials, since we have previously found that mice from the 129P3/J strain have difficulties to habituate to a mildly aversive environment [30,30,47]. As we continued with BALB/c in experiment 2, some extra trials were added to insure that the animals learned the odour associations.…”

Section: Justification Present Designmentioning

confidence: 99%

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A test to identify judgement bias in mice

Boleij

Klooster

Lavrijsen

et al. 2012

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 84%

Section: Justification Present Designmentioning

confidence: 99%

A test to identify judgement bias in mice

Boleij

Klooster

Lavrijsen

et al. 2012

Behavioural Brain Research

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“…prelimbic cortex and lateral septum) in comparison to BALB/c mice [2]. In a subsequent study we further demonstrated that exposure to chronic mild stress prior to repeated behavioural testing intensified the lack of habituation also in other behavioural parameters such as locomotion [6]. Other studies have found specific behavioural characteristics in 129P3 mice, such as less locomotor activity and more anxiety-related behaviour compared to for example C57BL/6 mice [7,8].…”

Section: Introductionmentioning

confidence: 84%

“…In contrast, such an increase was not observed in 129P3 mice. Apparently, the non-adaptive habituation phenotype in 129P3 mice determines their behaviour between as well as within sessions, a phenomenon found in different test systems [2,6,8], suggesting that this lack of habituation is a general characteristic in the 129P3 inbred strain, which is independent of their activity levels.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice

Salomons

Pinzon

Boleij

et al. 2012

Behavioral and Brain Functions

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BackgroundPrevious studies have demonstrated a profound lack of habituation in 129P3 mice compared to the habituating, but initially more anxious, BALB/c mice. The present study investigated whether this non-adaptive phenotype of 129P3 mice is primarily based on anxiety-related characteristics.MethodsTo test this hypothesis and extend our knowledge on the behavioural profile of 129P3 mice, the effects of the anxiolyticdiazepam (1, 3 and 5 mg/kg) and the putative anxiolytic metabotropic glutamate receptor 5 (mGlu5R) antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP, 3, 10 and 30 mg/kg) treatment on within-trial (intrasession) habituation, object recognition (diazepam: 1 mg/kg; MPEP 10 mg/kg) and on the central-nervous expression of the immediate early gene c-Fos (diazepam: 1 mg/kg; MPEP 10 mg/kg) were investigated.ResultsBehavioural findings validated the initially high, but habituating phenotype of BALB/c mice, while 129P3 mice were characterized by impaired intrasession habituation. Diazepam had an anxiolytic effect in BALB/c mice, while in higher doses caused behavioural inactivity in 129P3 mice. MPEP revealed almost no anxiolytic effects on behaviour in both strains, but reduced stress-induced corticosterone responses only in 129P3 mice. These results were complemented by reduced expression of c-Fos after MPEP treatment in brain areas related to emotional processes, and increased c-Fos expression in higher integrating brain areas such as the prelimbic cortex compared to vehicle-treated 129P3 mice.ConclusionsThese results suggest that the strain differences observed in (non)adaptive anxiety behaviour are at least in part mediated by differences in gamma-aminobutyric acid- A and mGluR5 mediated transmission.

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“…It is a type of emotion that has been shaped by natural selection, since it makes people alert to impending dangers (Richey et al, 2010). However, anxiety may cease to be a natural occurrence and progress to a pathological condition when it occurs disproportionately to the triggering event that causes it or when there is no apparent reason for its onset (Salomons et al, 2010).…”

Section: Introductionmentioning

confidence: 99%